Product Description
Imatinib CAS#152459-95-5 yog ib hom tshuaj rau qhov ncauj siv rau kev kho mob myelogenous leukemia (ua luv CML) ntawm cov tsos mob zoo ntawm Philadelphia chromosome (Ber-Abl). Nws yog qhov tsim nyog rau kev siv rau cov neeg laus hauv cov neeg laus hauv lub sijhawm hloov pauv, nrawm nrawm, thiab theem ntev nrog kev kho tsis ua haujlwm nrog interferon. CML yog ib hom kab mob hematopoietic qia cell uas tshwm sim los ntawm DNA abnormalities nyob rau hauv cov pob txha hlwb qia hlwb. DNA abnormalities yuav tsim cov proteins uas txawv txav thiab cuam tshuam rau cov txheej txheem tsim cov qe ntshav dawb hauv cov pob txha, ua rau muaj cov qe ntshav dawb nce ntxiv. CML tau muab faib ua peb theem suav nrog theem mob ntev, theem nrawm thiab theem kev kub ntxhov nrog lub sijhawm nruab nrab ntawm cov neeg mob nyob rau theem kev kub ntxhov tsuas yog 2-3 lub hlis.
Imatinib CAS#152459-95-5 kuj tseem muaj txiaj ntsig zoo hauv kev kho mob plab hnyuv stromal qog nrog kev ua haujlwm zoo li ntawm 50%.
Imatinib tuaj yeem siv rau kev kho mob myelogenous leukemia (cov ntawv luv CML) ntawm cov tsos mob zoo ntawm Philadelphia chromosome (Ber-Abl). Nws yog qhov tsim nyog rau kev siv rau cov neeg laus hauv cov neeg laus hauv lub sijhawm hloov pauv, nrawm nrawm, thiab theem ntev nrog kev kho tsis ua haujlwm nrog interferon.
Imatinib yog benzamide tau los ntawm kev sib xyaw ua ke ntawm carboxy pawg ntawm 4-[(4-methylpiperazin-1-} yl)methyl]benzoic acid nrog cov thawj aromatic amino pawg ntawm 4-methyl-N(3)-[4-(pyridin-3-}yl)pyrimidin-2-yl]benzene{10}},3-diamine. Siv (raws li nws cov ntsev mesylate) rau kev kho mob ntawm cov mob myelogenous leukemia thiab plab hnyuv stromal hlav. Nws muaj lub luag haujlwm ua apoptosis inducer, tyrosine kinase inhibitor thiab tus neeg sawv cev antineoplastic. Nws yog N-methylpiperazine, ib tug tswv cuab ntawm pyridines, ib tug tswv cuab ntawm benzamides, ib tug aromatic amine thiab ib tug tswv cuab ntawm pyrimidines. Nws muaj feem cuam tshuam nrog benzamide.
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Khoom npe |
Imatinib |
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Synonyms |
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-}(4-PYRIDIN-3-YL- PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE; Imatinib ({14}}[({15}}Methylpiperazin-1-yl)methyl]-N-[4-methyl{20}}[(4-pyridin{22 }}ylpyrimidin-2-yl)amino]phenyl]benzamide Imatinib dawb puag IMatinib(STI571); Imantinib puag; }yl-pyriMidin-2-ylaM IMatinib-D4 |
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CAS |
152459-95-5 |
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MF |
C29H31N7O |
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MW |
493.6 |
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EINECS |
604-855-6 |
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Khoom Pawg |
API |
Cim npe nrov: Imatinib CAS#152459-95-5, China Imatinib CAS#152459-95-5 manufacturers, lwm tus neeg
