Product Description
Iguratimod (T-614) CAS#123663-49-0, tus kab mob hloov tshuaj tiv thaiv kab mob rheumatic (DMARD) rau kev kho mob rheumatoid mob caj dab (RA). Preclinical hauv vivo cov kev tshawb fawb tau qhia tias iguratimod tau ua haujlwm zoo hauv cov qauv tsim kho mob caj dab (ED40=3.6 mg / kg) hauv nas thiab tseem ua tau zoo hauv hom II collagen-induced mob caj dab qauv hauv DBA / 1J nas ntawm 30 mg thiab 100 mg / kg.
Iguratimod, uas tau tshawb pom los ntawm Toyama Pharmaceuticals thiab sib koom ua ke tsim nrog Eisai hauv Nyij Pooj, tau pom zoo los ntawm PMDA (Lub Chaw Haujlwm Saib Xyuas Tshuaj thiab Kho Mob) ntawm Nyij Pooj thaum Lub Rau Hli 29, 2012 rau kev kho mob rheumatoid mob caj dab. Cov tshuaj no kuj yog tus kheej tsim los ntawm Simcere Pharmaceutical Group thiab tau cim tias yog Iremod® hauv Suav teb. Cov tshuaj tau nthuav tawm cov teebmeem inhibitory ntawm granuloma o, thiab tau pom tias muaj txiaj ntsig zoo rau kev tiv thaiv kev sib koom ua ke hauv kev mob caj dab adjuvant.
Thaum Lub Yim Hli 2011, Tuam Tshoj Lub Xeev FDA tau pom zoo Simcere Pharmaceutical Group daim ntawv thov tshuaj tshiab rau iguratimod (T-614), tus kab mob hloov kho cov tshuaj tiv thaiv rheumatic (DMARD) rau kev kho mob rheumatoid mob caj dab (RA). Preclinical hauv vivo cov kev tshawb fawb tau qhia tias iguratimod tau ua haujlwm zoo hauv cov qauv tsim kho mob caj dab (ED40=3.6 mg / kg) hauv nas thiab tseem ua tau zoo hauv hom II collagen-induced mob caj dab qauv hauv DBA / 1J nas ntawm 30 mg thiab 100 mg / kg.
Iguratimod Cov ntaub ntawv yooj yim
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Khoom npe |
Iguratimod |
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Synonyms |
IGURATIMOD; iguratimod (R&D); T 614; N-[7-methanesulfonamido-4-oxo-6-(phenoxy)chromen-3-yl]formamide; 3-(Formylamino)-7-(methylsulfonylamino)-6-phenoxy-4H-1-benzopyran-4-ib; N-[3-(Formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]methanesulfonamide; IguratiMod (T 614); N-(7-(MethylsulfonaMido)-4-oxo-6-phenoxy-4H-chroMen-3-yl)forMaMide |
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CAS |
123663-49-0 |
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MF |
C17H14N2O6S |
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MW |
374.37 |
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EINECS |
808-127-0 |
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Yam khoom |
Pharmaceutical nruab nrab; Tshuaj; API |
Iguratimod Chemical Properties
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Melting point |
238 0 mus rau 242 0 degree |
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Boiling point |
58 0.6 ± 60.0 degree (Predicted) |
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Qhov ntom |
1.52 ± 0.1 g / cm3 (Tshaj tawm) |
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Cia temp. |
Hauv qab roj inert (nitrogen lossis Argon) ntawm 2-8 degree |
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Solubility |
DMSO (me ntsis) |
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Daim ntawv |
Khoom |
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pka ua |
5.58 ± 0.20 (Kev kwv yees) |
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Xim |
Dawb rau Off-White |
Cim npe nrov: Iguratimod CAS#123663-49-0, Tuam Tshoj Iguratimod CAS#123663-49-0 manufacturers, lwm tus neeg
