Baloxavir CAS#1985605-59-1

Baloxavir yog ib qho tshuaj siv los kho tus kab mob khaub thuas.
Baloxavir marboxil yog ib qho kev xaiv inhibitor ntawm tus kab mob khaub thuas cap-dependent endonuclease. Nws tau qhia txog kev kho mob hauv cov qauv ua ntej ntawm tus kab mob khaub thuas A thiab B, suav nrog cov kab mob uas tiv taus cov tshuaj tiv thaiv kab mob tam sim no.

Baloxavir marboxil yog tus kws kho mob ua npaws, tshwj xeeb, ib qho enzyme inhibitor tsom rau tus kab mob khaub thuas 'cap-dependent endonuclease kev ua, ib qho ntawm cov haujlwm ntawm tus kab mob polymerase complex. Tshwj xeeb, nws inhibits txheej txheem hu ua cap snatching, uas tus kab mob no muab luv luv, capped primers los ntawm tus tswv tsev cell RNA transcripts, uas nws ces siv rau polymerase-catalyzed synthesis ntawm nws xav tau kab mob mRNAs. Ib qho polymerase subunit khi rau tus tswv tsev ua ntej-mRNAs ntawm lawv lub kaus mom 5, tom qab ntawd cov haujlwm polymerase's endonuclease catalyzes nws cleavage "tom qab 10-13 nucleotides". Raws li xws li, nws cov txheej txheem yog txawv los ntawm neuraminidase inhibitors xws li oseltamivir thiab zanamivir.

Cov kev mob tshwm sim tshwm sim tom qab ib koob tshuaj ntawm baloxavir marboxil suav nrog raws plab, mob ntsws, mob khaub thuas, mob taub hau, thiab xeev siab. Cov xwm txheej tsis zoo tau tshaj tawm hauv 21% ntawm cov neeg tau txais baloxavir, 25% ntawm cov neeg tau txais cov placebo, thiab 25% ntawm oseltamivir.

Cim npe nrov: Baloxavir CAS#1985605-59-1, China Baloxavir CAS#1985605-59-1 manufacturers, lwm tus neeg