Product Description
Olaparib CAS#763113-22-0, cov tshuaj no belongs rau ib chav kawm ntawm cov tshuaj hu ua poly (ADP-ribose) polymerase (PARP) inhibitors. PARP enzymes ua lub luag haujlwm tseem ceeb hauv DNA kho cov txheej txheem hauv hlwb. Hauv cov qog nqaij hlav qog noj ntshav nrog cov kev hloov pauv caj ces, xws li cov hauv BRCA1 thiab BRCA2 cov noob, txoj kev kho DNA feem ntau tsis zoo. Olaparib siv qhov zoo ntawm qhov tsis muaj zog no los ntawm inhibiting PARP enzymes, uas ua rau cov DNA puas nyob rau hauv cov hlwb thiab thaum kawg ua rau cell tuag.
Olaparib CAS#763113-22-0 muaj nyob rau hauv daim ntawv ntsiav tshuaj rau kev tswj qhov ncauj. Nws feem ntau yog sau rau cov neeg mob qog nqaij hlav zes qe menyuam, qog nqaij hlav qog nqaij hlav, lossis qog nqaij hlav hauv plab uas muaj kev hloov pauv hauv BRCA noob. Nws kuj tau pom cov lus cog tseg hauv kev kho mob lwm yam mob qog noj ntshav, suav nrog mob qog noj ntshav mis thiab mob qog nqaij hlav pancreatic.
Kev siv Olaparib CAS#763113-22-0 muaj ntau yam txiaj ntsig. Ua ntej, nws muab txoj hauv kev rau kev kho mob qog noj ntshav, tshwj xeeb tshaj yog tsom rau cov qog nqaij hlav qog noj ntshav nrog cov txheej txheem kho DNA tsis zoo thaum ua rau cov hlwb ib txwm muaj. Qhov no tuaj yeem ua rau muaj kev phiv tsawg dua piv rau cov tshuaj chemotherapy. Qhov thib ob, Olaparib tau pom tias muaj txiaj ntsig tseem ceeb hauv kev ncua ntev ntawm kev muaj sia nyob tsis muaj sia nyob thiab tag nrho cov ciaj sia nyob hauv cov neeg mob uas muaj qee yam mob qog noj ntshav.
Hauv kev sim tshuaj, Olaparib CAS#763113-22-0 tau pom cov txiaj ntsig zoo kawg. Cov neeg mob uas tau txais Olaparib muaj sijhawm ntev dua ua ntej lawv cov qog nqaij hlav loj zuj zus piv rau cov uas tau txais kev kho mob. Tsis tas li ntawd, cov tshuaj tau txais txiaj ntsig zoo, nrog rau cov kev mob tshwm sim xws li xeev siab, qaug zog, thiab ntshav liab. Txawm li cas los xij, cov kev mob tshwm sim no feem ntau tswj tau thiab tsis cuam tshuam rau lub neej zoo ntawm cov neeg mob.
Qhov kev tshawb pom thiab kev loj hlob ntawm Olaparib CAS#763113-22-0 sawv cev rau qhov kev hloov pauv loj hauv kev kho mob qog noj ntshav. Nws tau muab kev cia siab tshiab rau cov neeg mob uas nyuaj rau kho mob qog noj ntshav thiab tau qhib txoj hauv kev tshiab rau kev tshawb fawb thiab kev txhim kho hauv thaj chaw ntawm kev kho mob qog noj ntshav.
Olaparib Chemical Properties
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Khoom npe |
Olaparib |
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Synonyms |
1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl ]piperazin; Olaparid AZD2281; 4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-ib; 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]Methyl]-1(2H)-phthalazinone ; KU 59436; AZD2281(olaparib)/AZD-2281; AZD2281 (olaparib); 4-(3-(1-(cyclopropanecarbonyl)piperazine-4-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-ib |
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CAS |
763113-22-0 |
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MF |
C24H23FN4O3 |
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MW |
434.46 |
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EINECS |
642-941-5 |
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Yam khoom |
APIs |
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Qhov ntom |
1.43 |
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Solubility |
Soluble hauv DMSO (txog 33 mg / ml) lossis hauv Ethanol (txog 1.7 mg / ml) |
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pka ua |
12. |
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Daim ntawv |
khov kho |
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Xim |
Off-dawb |
Cim npe nrov: Olaparib CAS#763113-22-0, China Olaparib CAS#763113-22-0 manufacturers, lwm tus neeg
