Cov Khoom Siv Khoom Siv Khoom
| Yam | Cov ntsiab lus |
|---|---|
| Khoom npe | Acetaminophen (paracetamol) |
| Cas Tsis tau. | 103-90-2 |
| Txhais lus hais tias | N - (4-hydroxyphenyl) acetamide; Tylenol® / Panadol® (cov npe hom npe rau OTC tsim) |
| Molecular Cov Qauv | C₈h₉no₂ |
| Molecular hnyav | 151.16 |
| Kev tshwm sim | Dawb, crystalline hmoov; Ntxhiab, nrog ib qho iab iab me ntsis saj |
| Kev qhia tshwj xeeb | - Kws Tshuaj Ntsuam Xyuas: Purity ntau dua los yog sib npaug rau 99.0% (HPLC); Assay (raws li acetaminophen) 98.0% -102.0%; Melting point 168-172 degree; Poob rau ziab qis dua lossis sib npaug rau 0.5%; Cov hlau hnyav (PB tsawg dua lossis sib npaug rau 10ppm, Hg tsawg dua lossis sib npaug ntawm 1PPM, CD tsawg dua lossis sib npaug lossis sib npaug}OTC / Cov Khoom Noj Qib: Purity ntau dua los yog sib npaug rau 98.5% (HPLC); Ua raws li FDA / EMA OTC cov monographs; Tsis muaj kev tshawb nrhiav tsis txaus ntseeg (piv txwv li, 4-aminophenol tsawg dua lossis sib npaug nrog 0.005%, ib cov khoom muaj txiaj ntsig zoo) |
| Melting point | 168-172 Qib |
| So | Soluble me ntsis hauv dej (≈14 mg / ml ntawm 25 degree); Soluble hauv dej kub, ethanol, methanol, thiab acetone; Sparingly soluble hauv cloroform |
| Kev Cia | Khaws rau hauv qhov chaw txias (15-25 degree), qhuav, lub teeb -}}}}} kev muaj ntim; Ntim los tiv thaiv kev nqus dej noo thiab oxidation (zam kev tsim cov tshuaj lom neeg lom zem li 4-aminophenol); Txee Lub Neej: 36 lub hlis rau cov qhab-nees, 24 hlis rau OC qib |
Core Functions & Cov Ntawv Thov
Acetaminophen nthuav tawm nws cov kev cuam tshuam los ntawm kev xaiv los ntawm kev xaiv los ntawm cyclooxygingase (CMS}}}}}}}}}}}}}}}}}}}}}}}}} Tsis zoo li NSAIDs (piv txwv li, ibuprofen), nws muaj tsawg kawg nkaus ntawm peripheral cox enzymes, yog li nws tsis ua rau mob plab zom mov lossis anti-inflammatory. Qhov no ua rau nws zoo tagnrho rau cov neeg mob uas tsis tuaj yeem zam NSAIDs (piv txwv li, cov uas muaj mob txhab) lossis tsis tas yuav txo cov pa. Nws yog feem ntau siv nyob rau hauvtib neeg tshuaj, nrog kev siv tsiaj me me siv:
1. Tib neeg lub tsev muag tshuaj & OTC teb
1.1 Tshuaj Kho Mob (Siv Analesic)
Me - rau -}} me ntsis mob: Thawj - kab kev kho rau:
Mob taub hau (mob taub hau, mob plab (325-6 teev txhua 4-6 teev, Max
Kev mob musculoskeletal (mob nraub qaum, mob ib ce): 325-6 teev txhua qhov mob (piv txwv li, post- kev phais, mob cancer).
Kev mob hniav (mob hniav, post {{{}}}}}}}} {extraction mob siab dua li aspirin hauv qee cov neeg mob.
Kev mob plab me (mob pob ntseg, mob khaub ncaws hnav): hnub tim / kg / kg / teev / teev / teev
1.2 Kev Siv Ua Npau taws (antipyretic siv)
Mob fever: Pom zoo raws li thawj {- kab kab antipyretic rau txhua tus me nyuam yaus muaj ntau dua lossis sib npaug rau 2 lub hlis:
Cov neeg laus: 325-650 mg txhua 4-6 teev (Max 3000 Mg / Hnub) kom txog thaum tus mob khaub thuas, mob khaub thuas, lossis kis mob khaub thuas, mob khaub thuas).
Cov menyuam yaus: 10-15 mg / kg txhua 4-6 teev (Max 75 Mg / Kg / Kg / Hnub Tsis Txaus Siab Txuas ntxiv rau cov tshuaj aspirin rau cov menyuam yaus nrog tus kab mob kis).
Cov laus: 325 mg Txhua 4-6 teev (qis dua los txo lub nra ntawm lub nra (}}} eg, mob ntsws).
1.3 Kev Kho Mob
MultiSymptom tshuaj: Ib qho tseem ceeb tivthaiv ntawm cov tshuaj mob npaws / tshuaj tua kab mob npaws (ua ke nrog cov decongestants, los ntawm kev sib xyaw ua ke, lossis hnoos, mob taub hau, thiab mob ib ce.
Opioid sib txuas: Sau nrog opioids (piv txwv li, hydrocodone, oxycodone) rau kev mob siab (piv txwv li rov qab mob
2. Daim teb kws kho tsiaj (tus khub)
Acetaminophen yoglom rau miv(Ua rau lub siab ua rau lub siab puas thiab rho metemoglobinemia) thiab yuav tsum tsis txhob siv. Nws yog qee zaum siv tawm -} daim ntawv lo rau hauvdevTxog thaum luv -} Lub sij hawm mob / rever tswj, nyob rau hauv kev saib xyuas tsiaj txhu
Canine mob (piv txwv li, osteoarthritis): 10-15 mg / kg lub cev hnyav txhua 8-12 teev (max 30 mg / kg / hnub) rau 3-5 hnub. Ntev - siv tau yog zam vim daim siab muaj kev pheej hmoo.
Canine kub taub hau: 10-15 mg / kg txhua 8-12 teev kom txog thaum ua npaws daws, ua rau cov cim ntawm kev lom (ntuav, nkees, Jaundice).
Yam sib pauv: Tsis txhob siv cov miv, cev xeeb tub / dev / dev nrog ua ntej tus kab mob, anemia {}}
Kev Ua Tau Zoo & Kev Tsim Kho Kev Nyab Xeeb
Raws li lub thoob ntiaj teb siv ITC thiab cov tshuaj noj, acetaminophen yuav tsum ua kom muaj kev txhim kho kev ua tau zoo kom ntseeg tau tias muaj kev cuam tshuam zoo, thiab ua raws li cov qauv kev cai lij choj:
Cov Khoom Siv Raw & Synthesis: Tsim los ntawm kev lag luam tshuaj synthesis (piv txwv li, acetylation ntawm 4-aminophenol nrog acetic anhydride), ua raws li los ntawm kev ua kom huv ntawm recrystallization. Kev tswj hwm qhov tseem ceeb ntawm cov khoom pib (4-aminophenol) thiab cov tshuaj tiv thaiv tiv thaiv cov khoom noj muaj kuab lom (4-aminophenol txwv: tsawg dua los yog sib npaug rau 0.005% hauv Tshuaj Ntsuam Xyuas).
Cov txheej txheem ntau lawm:
Kws Tshuaj Ntsuam Xyuas: Tsim nyob rau hauv GMP - Daim ntawv cog lus ua haujlwm (tshuaj tua kab mob hauv chav kawm rau cov ntsiav tshuaj
Qib OTC: Undergoes ntxiv kev sim rau kev sib cais (ntau dua los yog sib npaug hauv 30 feeb hauv 30 feeb) thiab ua raws li cov lej OTC monographs (piv txwv li, FDA 21 CFRA 343).
Kev Ntsuas Xyuas Cov Quav:
| Ntsuas Yam | Txojkev | Kev lees txais cov txheej txheem |
|---|---|---|
| Purity & Assay | HPLC (C18, 245 nm nrhiav kom tau) | Kws Tshuaj Ntsuam Xyuas Tshuaj: Loj dua los yog sib npaug rau 99.0% Purity; Qib OTC: Loj dua los yog sib npaug rau 98.5% Purity |
| Lwm yam tshuaj (4-aminophenol) | HPLC (Gradient Elfution) | Tsawg dua los yog sib npaug rau 0.005% (cov qib tshuaj), tsawg dua los yog sib npaug rau 0.01% (OTC Qib) |
| Cov hlau hnyav | ICP - ms (inductively coupled ntshav -} cov spectrometry) | PB tsawg dua lossis sib npaug rau 10ppm, Hg tsawg dua lossis sib npaug ntawm 1PPM, Cd tsawg dua lossis sib npaug lossis sib npaug |
| Tus lej (cov ntsiav tshuaj) | USP Apparatus II (duav Qauv) | Ntau dua los yog sib npaug rau 80% yaj nyob rau hauv 30 feeb (pH 5.5 buffer) |
| Melting point | Txuj Ci Capillary | 168-172 Qib (Tsis Muaj Kev Decompose ua ntej melting) |
Kev Nyab Xeeb Kev Nyab Xeeb:Tib neeg siv:
Kev phom sij lom: Kev txhawj xeeb kev nyab xeeb tshaj plaws txhawj xeeb yoghepatic (nplooj siab) tsis ua haujlwmLos ntawm ntau dhau (tshaj 4000 mg / hnub nyob rau hauv cov neeg laus). Tsis txhob ua ke nrog lwm acetaminophen -}}}, Meds, txias dua kev haus luam yeeb.
Cov ntsiab lus: hypersensitivity rau acetaminophen; Tus kab mob siab loj (xws li, mob hlwb).
Cov neeg tshwj xeeb: txo cov tshuaj rau cov neeg mob uas mob siab, quav cawv, lossis kev lom zem (muaj kev pheej hmoo siab phem).
Siv Veterinary Siv:
Kev saib xyuas nruj: Tsuas yog siv cov dev nyob hauv cov kev taw qhia ntawm cov tsiaj; muaj cov tshuaj antidotes (piv txwv li, n - acetylcysteine) muaj nyob rau hauv cov ntaub ntawv ntawm overdose.
Miv toxicity: txawm tias cov tshuaj me me (piv txwv li, 10 mg / kg) tuaj yeem tua cov miv {{3} Tsis txhob tswj hwm.
Kev Koom Tes & Hu
Peb muab acetaminophen hauv ntau qib thiab lub cev cov ntaub ntawv kom tau sib ntsib ntau yam kev thov nyiaj:
Kws Tshuaj Ntsuam Xyuas: Hmoov zoo crystalline hmoov (1kg-100kg ib qho kev txiav txim) rau cov tshuaj noj, tsiav tshuaj, thiab muaj cov tshuaj muaj nyob hauv.
Qib OTC: Hmoov, granulated, lossis daim ntawv micronized (10kg-500kg ib zaug
Tus nqi -} muaj kev pabcuam ntxiv nrog:
Muab cov ntaub ntawv DMF (cov ntaub ntawv tshuaj) thiab CEP (Daim Ntawv Pov Thawj ntawm Kev Ua Haujlwm) rau cov khoom lag luam qib kawm los txhawb hauv EU, peb, thiab Asia.
Customized Ua: Micronization (rau kev ua tiav sai sai rau hauv kev ncua kev pediatric), granulation (rau cov ntsiav tshuaj), thiab impurity profiling.
Kev Qhia Txog Cov Cuab Yeej Siv: Cov txiaj ntsig zoo rau cov neeg tshwj xeeb (piv txwv, cov menyuam yaus), tswj kev ua raws li cov tswv yim tiv thaiv OTC.
Yog tias koj yog cov kws ua lag luam kws tshuaj, OTC cov tswv lag luam, lossis kws kho tsiaj ua lag luam encupise, thov hu rau peb kom paub txoj kev koom tes:
Cov ntaub ntawv tiv toj:
Tus email: {sales@huarongpharma.com
Xov tooj / WhatsApp: +86 13751168070
Peb ua raws li cov ntsiab cai ntawm "Kev Nyab Xeeb Ua tsaug, kev nyab xeeb ua ntej, thiab kev saib xyuas thoob ntiaj teb" thiab tos ntsoov yuav koom tes nrog ntiaj teb kev noj qab haus huv thiab OTC Indemelcare!
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Cim npe nrov: Acetaminophen (Paracetamol) Cas # 103-90-2, Tuam Tshoj Acetaminophen (Paracetamochen (Paracetamol) Cas # 103-90-2 Cov Chaw Tsim Tshuaj, Cov Chaw Tsim Khoom
