Cov Khoom Siv Khoom Siv Khoom
| Yam | Cov ntsiab lus |
|---|---|
| Khoom npe | Ibuprofen |
| Cas Tsis tau. | 15687-27-1 |
| Txhais lus hais tias | (±) -2- (4-isobutylphenyl) propanoic acid; Advil® / Motrin® (hom npe rau cov npe ntawm OTC) |
| Molecular Cov Qauv | C₁₃H₁₈O₂ |
| Molecular hnyav | 206.28 |
| Kev tshwm sim | Dawb rau tawm -} e} crystalline hmoov; Ntxhiab, nrog ib qho iab iab me ntsis saj |
| Kev qhia tshwj xeeb | - Kws Tshuaj Ntsuam Xyuas: Purity ntau dua los yog sib npaug rau 99.0% (HPLC); Assisy (ua ibuprofen) ntau dua lossis sib npaug ntawm 98.5% -101.5%; Melting point 74-77 degree; Poob rau ziab qis dua lossis sib npaug rau 0.5%; Cov hlau hnyav (PB tsawg dua lossis sib npaug rau 10ppm, Hg tsawg dua lossis sib npaug ntawm 1PPM, CD tsawg dua lossis sib npaug lossis sib npaug}OTC / Cov Khoom Noj Qib: Purity ntau dua los yog sib npaug rau 98.0% (HPLC); Ua raws li FDA / EMA OTC cov monographs; Tsis muaj kev kuaj tsis txaus ntseeg (tsawg dua los yog sib npaug rau 0.1% |
| Melting point | 74-77 degree |
| So | Xyaum ua insoluble hauv dej (≈21 mg / l ntawm 25 degree); Soluble hauv ethanol, methanol, acetone, thiab dilute sodium hydium hydium daws teeb meem; Sparingly soluble hauv cloroform |
| Kev Cia | Khaws rau hauv qhov chaw txias (15-25 degree), qhuav, lub teeb -}}}}} kev muaj ntim; Muab ntim rau kom tiv thaiv kev nqus dej noo thiab oxidation; Txee Lub Neej: 36 lub hlis rau cov qhab-nees, 24 hlis rau OC qib |
Core Functions & Cov Ntawv Thov
Ibuprofen Cas # 15687 - {}}}} {} {} {{- 2 (inducible, uppregulated thaum lub sij hawm o). Los ntawm thaiv kev cox, nws txo cov synthesis ntawm prostaglandins-lipid meriators uas ua rau mob mob, o, thiab kub taub hau. Nws cov kev ua ub no tawm tsam yog muaj txiaj ntsig tshwj xeeb rau cov mob uas muaj cov nqaij o, thaum nws cov nyhuv analgesic hom phiaj. Nws yog feem ntau siv nyob rau hauvtib neeg tshuaj, nrog kev siv tsiaj txhu me me:
1. Tib neeg lub tsev muag tshuaj & OTC teb
1.1 Tshuaj Kho Mob (Siv Analesic)
Mob mob: Thawj {- kab kev kho rau me {1} {{2} {}}}} moderate mob, suav nrog:
Mob taub hau (Tension mob taub hau, migraines): qhov ncauj txhaj tshuaj (200-400 mg txhua 4-6 teev, max 1200 mg / hnub rau cov neeg laus) kom txo qis kev siv mob thiab ntev.
Kev mob musculoskeletal (mob mob caj dab, mob caj dab, cov leeg): 400-66 teev (max 24/7 teev (Max 24 teev) kom txo qhov mob thiab txhim kho kev mus ncig.
Kev mob postperative: 400-800 mg Txhua 6-8 teev (feem ntau ua ke nrog acetaminophen rau txo cov nyhuv opioid siv.
Kev mob hniav (mob hniav, post {{{}} mg txhua 4-6 teev, nrog rau kev nrawm dua acetaminophen.
1.2 o txo (anti - kev siv tshuab
Mob mob ntev:
Osteoarthritis: 400-800 mg Peb zaug (Max 2400 mg / hnub) kom txo cov dej num txhua hnub (piv txwv li, taug kev, nce toj ntaiv).
Rheumatoid Mob caj pas: 800 MG peb mus rau plaub zaug txhua hnub (nyob rau hauv kev saib xyuas kev kho mob
Cov mob caj dab mlom (JIA): Cov koob tshuaj tiv thaiv kab mob (5-10 mg / kg / kg / hnub) los tswj kev mob thiab mob siab dua lossis sib npaug nrog 6 lub hlis.
1.3 Kev Siv Hluav Taws Xob Kub (Antipyretic Siv)
Mob fever: Pom zoo rau kev kub taub hau rau cov neeg laus thiab cov menyuam yaus (tshaj lossis sib npaug nrog kev kis mob (piv txwv, mob khaub thuas, kab mob khaub thuas,
Cov neeg laus: 200-400 mg txhua 4-6 teev (max 1200 mg / hnub) kom txog thaum fever daws teeb meem.
Cov menyuam yaus: 5-10 mg / kg txhua 6-8 teev (Max 10 teev (MG / kg / hnub), muab raws li kev ncua kev ncua lossis cov ntsiav tshuaj yooj yim.
2. Daim teb kws kho tsiaj (tus khub)
Ibuprofen CAS # 15687-27-1 yogtsis tau pom zoo rau miv(Kev pheej hmoo siab ntawm cov neeg tuag tsis ua haujlwm tsis ua haujlwm vim tsis muaj zog me me) tab sis qee zaum siv tawm -} daim ntawv lo rau hauvdevrau luv -} kev tswj hwm ntawm cov mob hnyav, nyob rau hauv kev saib xyuas tsiaj txhu
Canine asteoarthritis: 2-4 mg / kg lub cev hnyav ob zaug (max 8 mg / kg / hnub) rau 5-7 hnub kom txo tau mob pob txha thiab txhim kho kev muaj mob. Ntev -} siv tau yog zam vim yog cov kev pheej hmoo raum / hepatic toxicity.
Postperative mob hauv dev: 2-4 mg / kg ob zaug ib hnub twg rau 3-5 hnub (ua ke nrog lwm yam kev ua piv txwv zoo li tramadol) kom txo qis kev mob tom qab kev phais mob.
Qho piav: Tsis txhob siv cov miv, cev xeeb tub / cov dev / dev nrog tus kab mob rov qab / mob plab, ntshav roj paug, los sis los ntshav tsis sib haum.
Kev Ua Tau Zoo & Kev Tsim Kho Kev Nyab Xeeb
Raws li cov tshuaj OTC siv dav hlau thiab cov tshuaj noj, ibuprofen yuav tsum ua kom ntseeg tau tias muaj txiaj ntsig zoo kom ntseeg tau tias kev mob tshwm sim kom ntseeg tau tias muaj kev mob tshwm sim, thiab ua raws li cov kev cai tswj hwm:
Cov Khoom Siv Raw & Synthesis: Tsim los ntawm kev lag luam tshuaj synthesis (piv txwv li, friedel- sureylbenide, ua raws los ntawm hydrolysis thiab daws teeb meem ntawm enantiomers). Cov khoom lag luam yog ib qho kev sib cais sib xyaw (50% r {{5} {{} en} {10} {10}- tus r- kev hloov pauv yog ib nrab hloov dua siab tshiab rau s hauv lub cev.
Cov txheej txheem ntau lawm:
Kws Tshuaj Ntsuam Xyuas: Tsim nyob rau hauv GMP - Daim ntawv cog lus ua haujlwm (tshuaj tua kab mob hauv chav kawm
Qib OTC: Undergoes ntxiv kev sim rau kev sib nqus (kom muaj kev nqus sai) thiab ua raws li OTC monographs (piv txwv, FDA 21 CFRA 343).
Kev Ntsuas Xyuas Cov Quav:
| Ntsuas Yam | Txojkev | Kev lees txais cov txheej txheem |
|---|---|---|
| Purity & Assay | HPLC (C18, 220 NM Nrhiav Kom Tau) | Kws Tshuaj Ntsuam Xyuas Tshuaj: Loj dua los yog sib npaug rau 99.0% Purity; OC Qib: Ntau dua los yog sib npaug rau 98.0% kev coj dawb huv |
| Lwm yam tshuaj | HPLC (Gradient Elfution) | Ib leeg impurity tsawg dua los yog sib npaug rau 0.1%, tag nrho cov impurities tsawg dua los yog sib npaug rau 0.5% |
| Cov hlau hnyav | ICP - ms (inductively coupled ntshav -} cov spectrometry) | PB tsawg dua lossis sib npaug rau 10ppm, Hg tsawg dua lossis sib npaug ntawm 1PPM, Cd tsawg dua lossis sib npaug lossis sib npaug |
| Tus lej (cov ntsiav tshuaj) | USP Apparatus II (duav Qauv) | Ntau dua los yog sib npaug rau 80% yaj nyob rau 30 feeb (pH 7.2 tsis) |
| Enantiomer purity | Chiral HPLC | S - enantiomer ntau dua los yog sib npaug rau 48% (racemic sib tov) |
Kev Nyab Xeeb Kev Nyab Xeeb:Tib neeg siv:
Contraindications: Hypersensitivity rau NSAIDS (piv txwv li, aspirin- Tsis muaj hawb pob); nquag peptic rwj kab mob; Kev tsis ua rau lub raum loj / Hepatic tsis ua haujlwm; Thib peb-} trimeses cev xeeb tub (kev pheej hmoo ntawm fetal ductus arteriosus kaw).
Cov kev tsis zoo: Cov plab zom mov chim (xeev siab, mob plab zom mov (tsis muaj kev cuam tshuam nrog cov zaub mov lossis cov tshuaj tiv thaiv tsis sib haum (pob xoo, anegylaxis).
Kev Ceevev Ceev Faj: Tsis txhob tshaj cov koob tshuaj pom zoo (cov neeg laus: Max 2400: Max / MG / KG / KG / hnub) kom tsis txhob muaj kuab lom.
Siv Veterinary Siv:
Kev saib xyuas nruj: Tsuas yog siv cov dev nyob hauv cov kev taw qhia ntawm cov tsiaj; Saib xyuas rau cov cim ntawm lom (ntuav, raws plab, nce kev nqhis dej / tso zis).
Lwm txoj rau cov miv: Siv feline -} eg, meloxicam) hloov ntawm ibuprofen.
Kev Koom Tes & Hu
Peb muab CASE # 15687-27-1 nyob rau ntau qib thiab lub cev daim ntawv kom tau sib ntsib ntau yam kev thov nyiaj:
Kws Tshuaj Ntsuam Xyuas: Hmoov zoo crystalline hmoov (1kg-100kg ib qho kev txiav txim) rau cov tshuaj noj, tsiav tshuaj, thiab muaj cov tshuaj muaj nyob hauv.
Qib OTC: Hmoov lossis Granulated Daim Ntawv (10Kg-500kg ib zaug muaj peev xwm ntawm 3000KG) rau OTC ntsiav tshuaj, raug rau cov tsos mob.
Tus nqi -} muaj kev pabcuam ntxiv nrog:
Muab cov ntaub ntawv DMF (cov ntaub ntawv tshuaj) thiab CEP (Daim Ntawv Pov Thawj ntawm Kev Ua Haujlwm) rau cov khoom lag luam qib kawm los txhawb hauv EU, peb, thiab Asia.
Kev Ua Tau: Micronization (rau cov ntsiav tshuaj sai nyob rau hauv OTC ntsiav tshuaj), granulation (rau kev sib xyaw ua ke), thiab cov qauv ua yeeb yam.
Cov Kev Taw Qhia Txog Kev Ua Haujlwm: Kev Ua Haujlwm Txhim Kho rau Cov Neeg Mob Cov Neeg Mob Cov Neeg Mob, thiab Kev Tswj Xyuas thiab Kev Tswj Xyuas Kev Cai.
Yog tias koj yog cov kws ua lag luam kws tshuaj, OTC cov tswv lag luam, lossis kws kho tsiaj ua lag luam encupise, thov hu rau peb kom paub txoj kev koom tes:
Cov ntaub ntawv tiv toj:
Tus email: {sales@huarongpharma.com
Xov tooj / WhatsApp: +86 13751168070
Peb ua raws li cov ntsiab cai ntawm "Kev Ua Haujlwm Zoo, Kev Nyab Xeeb Qhov tseem ceeb, thiab kev siv tau" thiab OTC Indeplaj!
Cim npe nrov: Ibuprofen Cas # 15687-27-1, Tuam Tshoj IbUupropen Cas # 15687-27-1 Cov Chaw Tsim Khoom, Cov Chaw Tsim Khoom
