Dab tsi yog 4-Bromopyridine Hydrochloride CAS 19524-06-2
4-Bromopyridine hydrochloride CAS 19524-06-2 yog siv los ua ib qho khoom siv nruab nrab. Nws kuj yog siv los ua ib qho tseem ceeb raw khoom thiab nruab nrab siv hauv Organic Synthesis, Pharmaceuticals, Agrochemicals thiab Dyestuff. Soluble hauv DMSO, Methanol thiab Dej. Khaws ntawm -20 degree .
Vim li cas thiaj xaiv peb
Pab neeg zoo heev
Lub tuam txhab tau ntiav cov kws tshaj lij thiab PhDs hauv thaj chaw biochemical synthesis hauv Suav teb los ua cov kev taw qhia, thiab muaj ib pab pawg tseem ceeb uas muaj cov engineers laus Zeng Fanrong nrog cov kawm tiav qib siab thiab ntau yam kev tshawb fawb thiab kev tsim kho cov neeg ua haujlwm.
Kev Pabcuam Zoo
Cov neeg koom tes muaj kev txawj ntau yam lus thiab muaj peev xwm hloov mus rau ntau yam kev xav tau ntawm kev lag luam thoob ntiaj teb, tsim kom muaj kev sib koom tes ruaj khov nrog cov neeg siv khoom thoob ntiaj teb.
Quality Assurance
Peb tsim cov khoom lag luam ntawm tus txheej txheem siab tshaj plaws. Muaj cov thev naus laus zis thiab kev txawj ntse kom ncav cuag cov kev xav tau ntawm peb cov neeg siv khoom, peb xyuas kom meej tias cov khoom tsim tawm qhia txog peb txoj kev mob siab los muab peb cov neeg siv khoom nrog kev pabcuam sai, txhim khu kev qha thiab raug nqi yam tsis muaj kev cuam tshuam rau qhov zoo.
Yam khoom
4-Amino-2-Chloropyridine CAS#14432-12-3
Txoj kev npaj ntawm 4-Amino-2-Chloropyridine CAS 14432-12-3 yog siv isonicotinic acid ua raw khoom thiab chlorine nws nrog phosphorus oxychloride kom tau txais 2-chloropyridine-4-carboxylic kua qaub.
Ua ke 4-Aminopyridine CAS 504-24-5
Compounded 4-aminopyridine CAS 504-24-5 tuaj yeem thaiv cov kab hluav taws xob nyob ntawm cov poov tshuaj ion hauv lwm cov paj hlwb.
Tert-Butyl 2-Bromoisobutyrate CAS 23877-12-5
Yuav tert-Butyl -bromoisobutyrate CAS 23877-12-5 pharma intermediates los ntawm Huarong (Guangdong) Limited ntawm tus nqi sib tw zoo tshaj.
D(-)Threo-1-(4-Nitrophenyl)-2-Amino-1,3-Propanediol CAS 716-61-0
Qhov no yog Huarong (Guangdong) Pharmaceutical Co., Ltd. Peb yog cov chaw tsim khoom rau D(-)Threo-1-(4-nitrophenyl)-2-amino-1
Hmoov: Yog
Customized: Tsis-Customized
Ntawv pov thawj: GMP, ISO 9001,
Haum rau: Cov neeg laus
Xeev: Khoom
Purity: >98%
1-Cyclopropy1-6,7-Difluoro-1,4-Dihydhro-8-Methoxy-4-0x0-3-Quinoline Carboxylic Acid|CAS 112811-72-0
CAS Nr.: 112811-72-0
Cov roj formula: C14H11F2No4
EINECS: 601-205-3
Hom: Pharmaceutical Intermediates
2, 3-Pyrazinedicarboxylic Acid| CAS 89-01-0
Tshuaj Lub Npe: 2, 3-Pyrazinedicarboxylic acid
CAS Nr.: 89-01-0
Cov mis mos molecular: C6H4N2O4
Molecular Luj: 168.11
4-Aminobutyric Acid| CAS No.: 56-12-2
Cia Hom: Txias qhov chaw qhuav
Specification: 98%
Lub neej txee: 24 lub hlis
Pyrazine-2, 3-Dicarboxylic Anhydride|CAS 4744-50-7
Mf: Dawb hmoov
2, 3-Pyrazinedicarboxylic Acid: 0.55%
Kev ntsuam xyuas (HPLC): 99.02%
Aminopyridines yog ib pawg ntawm monoamino thiab diamino derivatives ntawm pyridine, uas inhibit voltage-gated potassium (Kv) channels. Tshwj xeeb, 2 broad-spectrum potassium channel blockers 4-Bromopyridine hydrochloride CAS 19524-06-2 (4-Bromopyridine hydrochloride CAS 19524-06-2) thiab 3,4-diaminopyridine (3, 4-DAP) tau siv los ua kev tshawb nrhiav cov tshuaj tshiab hauv ntau yam kab mob neurologic. Txawm hais tias muaj tseeb tias 3,4-DAP yog ib qho tshuaj tiv thaiv kab mob ntau dua ntawm cov kab mob potassium, 4-Bromopyridine hydrochloride CAS 19524-06-2 hla cov ntshav-hlwb barrier yooj yim dua1 thiab tau kho zoo dua hauv cov neeg mob MS , tshwj xeeb tshaj yog rau kev txhim kho qhov muag pom kev, 2 qaug zog, 3 kev paub, 4 thiab taug kev ceev.1 Ntxiv rau, 4-Bromopyridine hydrochloride CAS 19524-06-2 tau raug tshaj tawm los pab txhawb kev ua haujlwm ntawm neural hauv cov kab mob neurologic uas tsis yog MS.
Hauv kev noj qab haus huv axons, cov channel Kv1.1 thiab Kv1.2 yog pawg nyob ze ntawm cov nodes ntawm Ranvier.Cov kab no tau nthuav tawm tom qab demyelination thiab txav mus los ntawm ntu demyelinated. Nyob rau tib lub sijhawm, kev nthuav qhia ntawm cov channel no tau nce ntau dua.8 Qhov kev hloov pauv tsis raug ntawm Kv channel cuam tshuam rau kev sib kis ntawm cov peev txheej, ua rau muaj kev tsis taus mus tas li. 4-Bromopyridine hydrochloride CAS 19524-06-2 thaiv cov kab hluav taws xob tso tawm thiab yog li txhim kho cov teeb liab transduction.9,10 Cov Kv1.3 channel tau tshawb pom hauv tib neeg T-cells, tau pom tias tau nthuav tawm heev ntawm cov kab mob infiltrates hauv lub hlwb MS, thiab tau nthuav tawm ntawm macrophages, microglia, thiab effector nco T cells.13 Selective thiab nonselective Kv1.3 channel blockers yog li no yuav muab cov cuab yeej immunomodulatory los ntawm inhibiting cell proliferation thiab proinflammatory cytokine secretion.14 Kev tshawb fawb ua ntej xyoo 2009 ua tsis tiav los tsim 4-Bromopyridine hydrochloride CAS 19524-06-2 raws li kev kho mob rau MS vim hais tias cov tshuaj ntshav hauv cov neeg mob tsis tuaj yeem pom, nrog rau koob tshuaj ntau dhau yog txuam nrog kev pheej hmoo ntawm qaug dab peg thiab ua tsis taus pa Nco ntsoov.Yog li ntawd, fampridine, lub sij hawm tso tawm formulation ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2 tau tsim thiab tom qab ntawd tau txais kev pom zoo rau cov tsos mob ntawm taug kev tsis taus nyob rau hauv MS.Interestingly, tsis ntev los no, ib tug zuj zus lub cev ntawm Cov ntaub ntawv pov thawj qhia tias dhau ntawm cov tsos mob uas tau lees paub dav dav, 4-Bromopyridine hydrochloride CAS 19524-06-2 tej zaum yuav muaj kev tiv thaiv ntxiv.
Cov tshuaj tiv thaiv ntawm 4-Bromopyridine Hydrochloride CAS 19524-06-2
Vim hais tias ntawm cov electronegative nitrogen nyob rau hauv lub 4-Bromopyridine hydrochloride CAS 19524-06-2 nplhaib, 4-Bromopyridine hydrochloride CAS 19524-06-2 nkag mus rau hauv tsis yooj yim nkag mus rau hauv electrophilic aromatic hloov cov tshuaj tiv thaiv tshaj benzene derivatives.Xwb, nyob rau hauv cov ntsiab lus ntawm nws reactivity, 4-Bromopyridine hydrochloride CAS 19524-06-2 zoo li nitrobenzene.
Kev sib raug zoo 4-Bromopyridine hydrochloride CAS 19524-06-2 yog qhov yooj yim dua rau kev hloov pauv nucleophilic, raws li pov thawj los ntawm kev yooj yim ntawm metalation los ntawm cov hauv paus muaj zog organometallic.Qhov reactivity ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2 tuaj yeem yuav txawv rau peb pawg tshuaj. Nrog electrophiles, electrophilic hloov pauv yuav siv qhov chaw uas 4-Bromopyridine hydrochloride CAS 19524-06-2 qhia txog cov khoom muaj ntxhiab. Nrog nucleophiles, 4-Bromopyridine hydrochloride CAS 19524-06-2 reacts ntawm txoj hauj lwm 2 thiab 4 thiab yog li coj zoo li imines thiab carbonyls. Cov tshuaj tiv thaiv nrog ntau Lewis acids ua rau ntxiv rau cov nitrogen atom ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2, uas zoo ib yam li reactivity ntawm tertiary amines. Lub peev xwm ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2 thiab nws cov derivatives los oxidize, tsim amine oxides (N-oxides), kuj yog ib tug feature ntawm tertiary amines.
Lub chaw nitrogen ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2 nta ib qho yooj yim ib khub ntawm electrons. Cov khub ib leeg no tsis sib tshooj nrog lub nplhaib uas muaj ntxhiab π-system, yog li 4-Bromopyridine hydrochloride CAS 19524-06-2 yog qhov yooj yim, muaj cov khoom siv tshuaj lom neeg zoo ib yam li cov tertiary amines. Protonation muab pyridinium, C5H5NH +.The pKa ntawm conjugate acid (cov pyridinium cation) yog 5.25. Cov qauv ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2 thiab pyridinium yuav luag zoo ib yam. Lub pyridinium cation yog isoelectronic nrog benzene. Pyridinium p-toluenesulfonate (PPTS) yog ib qho piv txwv pyridinium ntsev; nws yog tsim los ntawm kev kho mob 4-Bromopyridine hydrochloride CAS 19524-06-2 nrog p-toluenesulfonic acid. Ntxiv rau protonation, 4-Bromopyridine hydrochloride CAS 19524-06-2 tau txais N-centred alkylation, acylation, thiab N-oxidation. 4-Bromopyridine hydrochloride CAS 19524-06-2 thiab poly(4-vinyl) 4-Bromopyridine hydrochloride CAS 19524-06-2 tau pom tias ua cov xaim hluav taws xob nrog cov qauv polyenimine zoo kawg nkaus ntawm UV irradiation, txheej txheem uas suav nrog tsawg kawg qee qhov pom lub teeb pom kev los ntawm hnub nyoog 4-Bromopyridine hydrochloride CAS 19524-06-2 qauv. Cov xov hlau no tau raug kwv yees kwv yees tias yog ob qho tib si muaj txiaj ntsig zoo electron pub thiab txais, thiab tseem muaj peev xwm tiv taus huab cua oxidation.
Cov khoom ntawm 4-Bromopyridine Hydrochloride CAS 19524-06-2
Lub cev muaj zog
Crystal qauv ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2
4-Bromopyridine hydrochloride CAS 19524-06-2 yog diamagnetic. Nws qhov tseem ceeb tsis yog: siab 5.63 MPa, kub 619 K thiab ntim 248 cm3 / mol.
Qauv
4-Bromopyridine hydrochloride CAS 19524-06-2 ua rau C5N hexagon. Kev hloov pauv me ntsis ntawm C-C thiab C-N nrug raws li kev sib cog lus tau pom.
Crystallography
4-Bromopyridine hydrochloride CAS 19524-06-2 crystallizes nyob rau hauv lub orthorhombic siv lead ua ke nrog qhov chaw pab pawg neeg Pna21 thiab lattice parameters a=1752 pm, b=897 pm, c=1135 pm, thiab 16 formula units ib chav cell (tseem ntsuas ntawm 153 K). Rau kev sib piv, crystalline benzene kuj yog orthorhombic, nrog rau qhov chaw pab pawg Pbca, a=729.2 teev tsaus ntuj, b=947.1 teev tsaus ntuj, c=674.2 teev tsaus ntuj (ntawm 78 K), tab sis tus naj npawb ntawm cov molecules ib lub cell tsuas yog 4.[18] Qhov sib txawv no yog ib feem cuam tshuam rau qhov qis qis ntawm tus neeg 4-Bromopyridine hydrochloride CAS 19524-06-2 molecule (C2v vs D6h rau benzene). A trihydrate (4-Bromopyridine hydrochloride CAS 19524-06-2·3H2O) paub; nws kuj crystallizes nyob rau hauv ib tug orthorhombic system nyob rau hauv lub space group Pbca, lattice parameters a=1244 pm, b=1783 pm, c=679 pm thiab yim formula units ib unit cell (tseem ntawm 223 K ) [21]
Spectroscopy
Lub qhov muag nqus spectrum ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2 nyob rau hauv hexane muaj bands ntawm lub wavelengths ntawm 195, 251, thiab 270 nm. Nrog rau qhov extinction coefficients (ε) ntawm 7500, 2000, thiab 450 L·mol−1·cm−1, cov qhab no raug muab rau π → π *, π → π *, thiab n → π * kev hloov. Cov khoom sib xyaw ua kom pom cov fluorescence tsawg heev.
1H nuclear magnetic resonance (NMR) spectrum qhia cov cim rau -(δ 8.5), -(δ7.5) thiab -protons (δ7). Los ntawm qhov sib txawv, lub teeb liab proton rau benzene pom ntawm δ7.27. Kev hloov tshuaj lom neeg loj dua ntawm - thiab -protons hauv kev sib piv rau benzene tshwm sim los ntawm qis electron ceev hauv - thiab -txoj hauj lwm, uas tuaj yeem muab tau los ntawm cov qauv resonance. Qhov xwm txheej zoo sib xws rau 13C NMR spectra ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2 thiab benzene: 4-Bromopyridine hydrochloride CAS 19524-06-2 qhia ib triplet ntawm δ( -C) { {21}} ppm, δ( -C)=124 ppm thiab δ( -C)=136 ppm, thaum benzene muaj ib kab ntawm 129 ppm. Txhua qhov kev hloov pauv tau raug hais rau cov tshuaj tsis muaj kuab lom.4-Bromopyridine hydrochloride CAS 19524-06-2 yog pom zoo los ntawm cov pa roj chromatography thiab cov txheej txheem loj spectrometry.
Kev sib khi
4-Bromopyridine hydrochloride CAS 19524-06-2 nrog nws tus khub dawb electron
4-Bromopyridine hydrochloride CAS 19524-06-2 muaj ib tug conjugated system ntawm rau π electrons uas yog delocalized hla lub nplhaib. Cov molecule yog planar thiab, yog li, ua raws li Hückel cov qauv rau cov tshuab aromatic. Nyob rau hauv sib piv rau benzene, lub electron ceev tsis sib npaug zos rau ntawm lub nplhaib, xav txog qhov tsis zoo inductive nyhuv ntawm nitrogen atom. Vim li no, 4-Bromopyridine hydrochloride CAS 19524-06-2 muaj lub sijhawm dipole thiab tsis muaj zog resonant stabilization tshaj benzene (resonance zog 117 kJ/mol hauv 4-Bromopyridine hydrochloride CAS 19524-06-2 vs. 150 kJ / mol hauv benzene).
Lub nplhaib atoms hauv 4-Bromopyridine hydrochloride CAS 19524-06-2 molecule yog sp2-hybridized. Cov nitrogen yog koom nrog hauv π-bonding aromatic system siv nws cov unhybridized p orbital. Cov khub ib leeg yog nyob rau hauv ib qho sp2 orbital, tawm sab nraud ntawm lub nplhaib nyob rau hauv tib lub dav hlau raws li σ bonds. Raws li qhov tshwm sim, tus khub ib leeg tsis ua rau lub cev muaj zog, tab sis tseem ceeb cuam tshuam rau cov khoom siv tshuaj lom neeg ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2, vim nws yooj yim txhawb kev sib cog lus ntawm kev tawm tsam electrophilic. Txawm li cas los xij, vim yog kev sib cais ntawm ib leeg khub los ntawm lub nplhaib aromatic, lub nitrogen atom tsis tuaj yeem pom qhov zoo mesomeric nyhuv.
Ntau cov analogues ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2 paub qhov twg N yog hloov los ntawm lwm cov heteroatoms los ntawm tib kem ntawm Lub Sij Hawm Lub Sij Hawm . Kev hloov ntawm ib C–H hauv 4-Bromopyridine hydrochloride CAS 19524-06-2 nrog rau qhov thib ob N ua rau diazine heterocycles (C4H4N2), nrog rau cov npe pyridazine, pyrimidine, thiab pyrazine.
Dab tsi yog 4-Bromopyridine Hydrochloride CAS 19524-06-2 Siv rau hauv Organic Synthesis?
4-Bromopyridine hydrochloride CAS 19524-06-2, tseem hu ua 4-Bromopyridine hydrochloride CAS 19524-06-2, yog dawb crystalline khoom ntawm chav tsev kub thiab siab. Nws muaj qee yam hygroscopicity thiab yooj yim deliquescent thaum raug dej. 4-Bromopyridine hydrochloride CAS 19524-06-2 yog pyridine ntsev feem ntau siv los ua kev sib txuas reagent thiab precursor molecule rau pyridine derivatives hauv organic synthesis chemistry. Nws feem ntau kho nrog lub hauv paus tso tawm 4-bromopyridine. Vim muaj kev sib koom tes ntawm pyridine, cov tshuaj no feem ntau yog siv los ua cov khoom sib dhos rau kev npaj cov tshuaj supramolecular.
Cov khoom
Neutralization cov tshuaj tiv thaiv ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2
Hauv cov tshuaj tiv thaiv qhuav, 4-Bromopyridine hydrochloride CAS 19524-06-2 (1 sib npaug) thiab anhydrous potassium carbonate (10 sib npaug) yog sib xyaw thiab nplawm hauv acetonitrile ua cov kuab tshuaj nyob rau hauv chav sov li 6 teev. Tom qab cov tshuaj tiv thaiv tiav, cov tshuaj tiv thaiv sib tov yog lim los ntawm anhydrous magnesium sulfate kom tshem tawm cov ntsev los ntawm cov tshuaj tiv thaiv. Qhov tshwm sim cov tshuaj tiv thaiv filtrate yog concentrated nyob rau hauv chav tsev kub kom evaporate cov kuab tshuaj nyob rau hauv cov tshuaj tiv thaiv system, thiab cov residue tau txais yog lub hom phiaj cov khoom molecule, uas yuav siv tau rau cov tshuaj tiv thaiv tom ntej no tsis muaj kev sib cais thiab purification.
Daim ntawv thov
4-Bromopyridine hydrochloride CAS 19524-06-2 yog pyridine ntsev feem ntau siv los ua ib qho kev sib txuas reagent thiab precursor molecule rau pyridine derivatives hauv organic synthesis chemistry. Nws feem ntau kho nrog lub hauv paus tso tawm 4-bromopyridine. Cov tshuaj tiv thaiv sib txuas ntawm 4-Bromopyridine hydrochloride CAS 19524-06-2 feem ntau yog siv los tsim CC, CN, CO, thiab lwm yam kev sib txuas. Cov tshuaj tiv thaiv muaj xws li Suzuki coupling cov tshuaj tiv thaiv, Stille coupling cov tshuaj tiv thaiv, Heck coupling cov tshuaj tiv thaiv, thiab lwm yam Hauv cov tshuaj tiv thaiv no, 4-Bromopyridine hydrochloride CAS 19524-06-2 tuaj yeem ua tus thawj molecule rau pyridine, uas yog hloov dua siab tshiab rau hauv lub hom phiaj cov khoom los ntawm kev hloov cov tshuaj tiv thaiv, condensation tshua, thiab lwm yam tshuaj tiv thaiv cov kauj ruam. Pyridine muaj kev sib koom tes muaj peev xwm thiab muaj peev xwm sib txuas nrog hydrogen, yog li nws tuaj yeem sib sau ua ke rau hauv ntau cov qauv supramolecular nrog rau lwm cov molecules los ntawm kev tsis sib haum xeeb. 4-Bromopyridine hydrochloride CAS 19524-06-2, raws li ib tug derivative ntawm pyridine, kuj muaj xws li kev sib koom tes thiab hydrogen bonding peev xwm, ua rau nws yog ib qho ntawm cov khoom sib dhos rau supramolecular compounds.
Tuam txhab Taw Qhia
Huarong (Guangdong) Pharmaceutical Co., Ltd. yog lub tuam txhab tshuaj nruab nrab tsim thiab tsim khoom, raws li kev sib xyaw ntawm DPP -4 inhibitor intermediates. Nws ua tiav tsim cov kab ntau lawm rau cov khoom xyaw nquag ntawm cov tshuaj tua kab mob bisamide, nrog rau cov kab ntau lawm rau chiral synthesis thiab enzymatic synthesis ntawm compound intermediates. Tsim kom muaj kev tshaj lij thiab ntsuab kev tsim tawm hauv paus rau cov tshuaj thiab tshuaj tua kab intermediates.
Lub tuam txhab tau tsim nyob rau lub Kaum Ib Hlis 8, 2023, nrog ib hom ntawm lwm lub tuam txhab kev lav phib xaub thiab sau npe hauv Nanxiong City, Shaoguan City. Lub tuam txhab cov phiaj xwm phiaj xwm npog thaj tsam ntawm 53406.97 square meters. Lub tsev tseem ceeb suav nrog 5 Chav Kawm A multifunctional rhiav, 1 Chav Kawm C Rhiav, 1 lub tsev ua tiav, 1 kev tshuaj xyuas zoo thiab kev tshawb fawb thiab kev tsim kho lub tsev, nrog rau kev txhawb zog thiab kev tiv thaiv ib puag ncig. Kev tsim kho ntawm qhov project npog thaj tsam ntawm 19042 square metres, nrog thaj tsam ntawm 50137 square metres thiab thaj tsam ntawm 0.94.
Nug cov lus nug
Cim npe nrov: 4-bromopyridine Hydrochloride CAS 19524-06-2, Tuam Tshoj 4-bromopyridine Hydrochloride CAS 19524-06-2 tuam ntxhab, lwm tus neeg
