Product Description
Quinidine sulfate yog ib daim ntawv ntsev ntawm quinidine, ib txwm tshwm sim alkaloid tau los ntawm cov tawv ntoo ntawm tsob ntoo cinchona. Nws zoo nkaus li dawb crystalline hmoov nrog ib tug iab saj.
Lub cev, quinidine sulfate kuj ruaj khov nyob rau hauv ib txwm cia cov xwm txheej. Nws yog me ntsis soluble hauv dej tab sis ntau soluble hauv qee cov organic solvents.
Quinidine sulfate feem ntau paub txog nws cov khoom tiv thaiv arrhythmic. Nws ua los ntawm inhibiting cov sodium channels hauv plawv cov leeg hlwb, yog li ua kom qeeb ntawm cov hluav taws xob impulses thiab ncua lub sijhawm refractory. Qhov no pab ua kom lub plawv dhia zoo li qub thiab tiv thaiv lub plawv dhia tsis zoo xws li atrial fibrillation, atrial flutter, thiab ventricular tachycardia.
Los ntawm kev txo cov excitability ntawm lub plawv cov leeg, quinidine sulfate kuj tseem tuaj yeem tiv thaiv qhov rov tshwm sim ntawm arrhythmias thiab txhim kho tag nrho cov hlab plawv.
Ntxiv nrog rau nws cov teebmeem antiarrhythmic, quinidine sulfate muaj cov tshuaj tiv thaiv kab mob. Nws yog ib qho ntawm thawj cov tshuaj siv los kho tus kab mob malaria thiab tseem siv tau rau qee kis, tshwj xeeb tshaj yog thaum lwm cov tshuaj tiv thaiv kab mob tsis zoo lossis thaum tus kab mob malaria tau txhim kho.
Quinidine sulfate ua los ntawm kev cuam tshuam cov metabolism hauv cov kab mob malaria parasite, tshwj xeeb los ntawm inhibiting enzyme dihydrofolate reductase. Qhov no ua rau muaj kev cuam tshuam ntawm DNA synthesis thiab thaum kawg kev tuag ntawm cov cab.
Lub ntsiab mechanism ntawm kev txiav txim ntawm quinidine sulfate raws li ib tug antiarrhythmic tshuaj yog blockade ntawm sodium raws nyob rau hauv lub plawv mob hlwb. Qhov no ua rau txo qis tus nqi ntawm depolarization thiab conduction tshaj tawm ntawm hluav taws xob impulses. Los ntawm kev ncua lub sij hawm refractory, quinidine sulfate txo qhov muaj feem ntawm rov nkag arrhythmias.
Qhov blockade ntawm sodium channels kuj ua rau txo qis hauv qhov tsis siv neeg ntawm cov pacemaker hlwb, ntxiv rau kev ua kom lub plawv dhia zoo li qub.
Ntxiv nrog rau sodium channel blockade, quinidine sulfate kuj muaj qee qhov kev txwv ntawm potassium channel. Qhov no tuaj yeem ua rau lub sijhawm ntev ntawm qhov kev txiav txim siab ntev thiab lub sijhawm ua haujlwm zoo, uas tuaj yeem ua rau nws cov teebmeem antiarrhythmic.
Quinidine sulfate kuj tseem muaj lwm yam kev ua haujlwm, xws li inhibition ntawm calcium channels thiab kev hloov pauv ntawm kev ua haujlwm ntawm lub paj hlwb. Cov kev cuam tshuam ntxiv no tuaj yeem ua rau nws txoj haujlwm pharmacological tag nrho.
Quinidine sulfate yog siv los kho ntau lub plawv arrhythmias, suav nrog atrial fibrillation, atrial flutter, ventricular tachycardia, thiab ntxov ntxov ventricular contractions. Nws feem ntau yog siv ua ke nrog lwm cov tshuaj antiarrhythmic lossis raws li kev kho mob thib ob thaum lwm cov tshuaj tsis zoo lossis tsis zam.
Qhov ntau npaum ntawm quinidine sulfate rau kev kho mob ntawm arrhythmias yog ua tib zoo txiav txim siab raws li tus neeg mob lub hnub nyoog, qhov hnyav, thiab mob hauv qab. Kev soj ntsuam ze ntawm tus neeg mob lub plawv dhia thiab qib ntshav ntawm cov tshuaj yog qhov tseem ceeb los xyuas kom meej tias kev kho mob zoo thiab zoo.
Raws li tau hais ua ntej lawm, quinidine sulfate yog siv rau kev kho mob malaria, tshwj xeeb tshaj yog nyob rau hauv cov xwm txheej uas lwm cov tshuaj tiv thaiv kab mob tsis zoo lossis thaum tus kab mob malaria tau txhim kho. Nws feem ntau yog muab tso rau hauv cov hlab ntsha hauv qhov mob hnyav ntawm malaria.
Quinidine sulfate dihydrate Cov ntaub ntawv yooj yim
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Khoom npe |
Quinidine sulfate dihydrate |
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Synonyms |
Quinidin; Quinidine dihydrate sulfate ntsev; Quinidine sulfate dehydrate; 6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol hemisulfate hydrate; Cinchonan -9-ol, 6'-methoxy-, (9S)-, sulfate (2: 1) (ntsev), monohydrate; Quinidine sulfate (2: 1) ( ntsev) monohydrate; Quinidine sulfate hydrate; Quinidine sulfate monohydrate |
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CAS |
6591-63-5 |
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MF |
C20H26N2O6S |
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MW |
422.5 |
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EINECS |
678-472-8 |
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Yam khoom |
Monovalent Ion Channels; Lwm yam Sodium Channel Modulators; Alkaloids; Biochemistry; rau kev daws teeb meem ntawm acids; Sodium Channel Modulators; chiral; Kev daws teeb meem kho qhov muag; Quinoline Alkaloids; Synthetic Organic Chemistry |
Quinidine sulfate dihydrate tshuaj muaj zog
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Melting point |
212-214 degree (dec.) (lit.) |
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Solubility |
Me ntsis soluble nyob rau hauv dej, soluble nyob rau hauv boiling dej thiab nyob rau hauv ethanol (96 ib xees), xyaum insoluble nyob rau hauv acetone. |
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Xim |
Dawb rau Off-White |
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Dej Solubility |
Soluble hauv chloroform, dej (11 mg / ml ntawm 20 degree), cawv, thiab ethanol (50 mg / ml). |
Cim npe nrov: Quinidine Sulfate CAS#{0}}, Tuam Tshoj Quinidine Sulfate CAS#6591-63-5 manufacturers, lwm tus neeg
