Khoom taw qhia
Candesartan cilexetil yog ib daim ntawv prodrug ntawm angiotensin II hom 1 receptor (AT1) antagonist candesartan . Atacand tau tsim tawm hauv Australia, Belgium, Canada, Denmark, Finland, Netherlands, Norway, Sweden, S. Africa thiab Asmeskas ua tus neeg sawv cev tiv thaiv kab mob siab. Cov kev tshawb fawb kws tshuaj tau qhia tias Atacand yog hais txog 10-fold muaj zog tshaj Losartan thiab muaj kev tshem tawm ntev ib nrab-lub neej. Zoo li losartan, Atacand hloov mus rau nws daim ntawv nquag thaum lub sij hawm GI absorption (ntawm ester hydrolysis). Nws yog ib tug muaj zog antagonist ntawm angiotensin II hom 1 receptors. Qhov no tshwm sim los ntawm kev sib khi nruj thiab qeeb qeeb, thiab muaj zog dua li ACE inhibitors. Nws tau txais txiaj ntsig zoo (tuaj yeem coj los ntawm cov neeg laus thiab cov neeg mob ntshav qab zib hom II) thiab tsis muaj teebmeem rau poj niam txiv neej.
Ntau lawm specification
|
Candesartan cilexetil tshuaj muaj zog |
|
Melting point |
168-170?C |
|
Boiling point |
843.3 ± 75. 0 degree (Predicted) |
|
ceev |
1.37 ± 0.1 g / cm3 (Tshaj tawm) |
|
cia temp. |
2-8 degree |
|
solubility |
DMSO: Ntau dua lossis sib npaug li 15mg / mL |
|
pka ua |
pKa 3.55 (H2O t=25. }.025) (Tsis paub meej) |
|
daim ntawv |
hmoov |
|
xim |
dawb rau beige |
|
lw max |
304nm (EtOH) (lit.) |
|
Merck |
14,1739 |
|
BCS Chav Kawm |
2 |
|
InChIKey |
GHOSNRCGJFBJIB-UHFFFAOYSA-N |
|
SMILES |
C1(OCC)N(CC2=CC=C3=CC=CC=C3C3=NNN=}} N3)C=C2)C2=C(C(C(OC(OC(OC3CCCCCC3)=}O)C)=O)C=CC{ {18}}C2N=1 |
|
CAS DataBase Reference |
145040-37-5(CAS DataBase Reference) |
Cim npe nrov: candesartan cilexetil cas#145040-37-5, Tuam Tshoj candesartan cilexetil cas#145040-37-5 manufacturers, lwm tus neeg
