Prednisolone (CAS No.: 50-24-}8) - Muaj zog Glucocorticoid rau Kev Tiv Thaiv Kab Mob & Kev Tiv Thaiv Kab Mob
Raws li tus kws tshaj lij ntawm cov kws kho mob - qib steroid active cov khoom xyaw, peb muab siab - purity Prednisolone uas nruj me ntsis raws li lub ntiaj teb no pharmacopoeia cov qauv (USP, EP, BP, CP). Ib qho hluavtaws glucocorticoid uas muaj zog tiv thaiv - inflammatory kev ua ntau dua endogenous hydrocortisone (thiab cov teebmeem mineralocorticoid qis), nws yog cov tshuaj tseem ceeb rau kev kho ntau yam kab mob inflammatory, allergic, thiab autoimmune kab mob nyob rau hauv tib neeg, txhawb ntau hom tshuaj formulations.
Product Basic Information
| Yam khoom | Paub meej |
|---|---|
| Khoom npe | Prednisolone |
| CAS Nr. | 50-24-8 |
| Synonyms | 11 ,17 ,21-Trihydroxypregna-1,4-diene-3,20-dione; Delta-1-cortisol |
| Molecular Formula | C₂₁H₂₈O₅ |
| Molecular Luj | 360.44 |
| Qhov tshwm sim | Dawb los yog yuav luag dawb crystalline hmoov; Tsis hnov tsw |
| Specification | Pharmaceutical qib; Purity Ntau dua lossis sib npaug li 97.0% (HPLC); Poob ntawm ziab Tsawg dua lossis sib npaug li 1.0%; Residue ntawm ignition Tsawg dua los yog sib npaug rau 0.1%; Cov hlau hnyav tsawg dua lossis sib npaug li 10ppm; Ua raws li cov kuab tshuaj residue (xws li, methanol, ethyl acetate) txwv |
Product Core Functions & Applications
Prednisolone exerts nws cov tshuaj pharmacological los ntawm kev khi rau glucocorticoid receptors, inhibiting kev tso tawm ntawm inflammatory mediators (piv txwv li, prostaglandins, leukotrienes) thiab suppressing txawv teb chaws lub cev. Nws muaj zog los tiv thaiv- kev ua ub no (≈4x ntawm hydrocortisone) thiab tsis muaj zog mineralocorticoid nyhuv (tsawg kawg cuam tshuam rau dej-electrolyte tshuav) ua rau nws haum rau ntev - lub sij hawm kev kho mob thiab kev kho mob hauv zos. Nws yog tsuas yog siv rau hauvhuman pharmaceutical formulations(Qeb Veterinary muaj nyob rau ntawm qhov kev thov):
1. Kev Kho Mob (Qhov ncauj / txhaj tshuaj)
Cov kab mob autoimmune: Ua ntej- kab kev kho mob rau cov mob xws li kab mob lupus erythematosus (SLE), rheumatoid mob caj dab, Sjogren's syndrome, thiab polymyositis, txo kev tiv thaiv kab mob - kho cov ntaub so ntswg puas.
Mob hnyav heev: Tswj tus mob hawb pob exacerbations, chronic obstructive pulmonary disease (COPD) flare-ups, thiab inflammatory plob tsis so tswj kab mob (Crohn's disease, ulcerative colitis) los tswj cov tsos mob mob.
Hematological Disorders: Siv los kho cov tshuaj tiv thaiv kab mob thrombocytopenic purpura (ITP), autoimmune hemolytic anemia, thiab leukemia/lymphoma (raws li kev siv tshuaj kho mob kom txo tau qhov mob thiab kev mob tshwm sim).
Daim ntawv noj tshuaj: Cov ntsiav tshuaj ntawm qhov ncauj (rau kev kho lub sijhawm ntev) thiab cov tshuaj txhaj tshuaj (rau thaum muaj xwm txheej ceev, xws li kev tsis haum tshuaj hnyav, cerebral edema, los ntawm kev txhaj tshuaj rau hauv cov hlab ntsha / intramuscular).
2. Local & Topical Therapy
Dermatology: Formulated rau hauv qab zib, tshuaj pleev, thiab tshuaj pleev ib ce rau cov kab mob loj heev ntawm daim tawv nqaij, xws li:
Nruab nrab-rau- mob atopic dermatitis, psoriasis (plaque- hom)
Allergic contact dermatitis, bullous pemphigoid
Nws txhim kho los tiv thaiv - cov nyhuv inflammatory hais txog cov xwm txheej tsis teb rau cov tshuaj steroids (xws li hydrocortisone).
Ophthalmology: Cov tshuaj pleev qhov muag / tshuaj pleev rau qhov tsis yog- kis kab mob ntawm lub qhov muag, suav nrog uveitis, keratitis (tsis yog- kis), thiab tom qab- kab mob cataract o, txo qhov mob thiab tiv thaiv qhov caws pliav.
Ua pa: Cov tshuaj nqus tau pa (aerosols, qhuav hmoov inhalers) kom ntev - tswj kev mob hawb pob thiab COPD, tsom rau txoj hlab ntsws o thaum txo cov kev mob tshwm sim.
Quality & Safety Assurance
Prednisolone, raws li kev tshuaj xyuas glucocorticoid nrog cov haujlwm muaj zog, yuav tsum muaj kev tswj xyuas kom zoo los xyuas kom meej tias muaj txiaj ntsig thiab txo cov kev pheej hmoo ntawm kev nyab xeeb:
Raw Material Sourcing: Siv siab -purity pib cov ntaub ntawv (piv txwv li, hydrocortisone los yog pregnenolone derivatives) thiab advanced chemical synthesis (qhia ob daim ntawv cog lus ntawm C1-2 los txhim kho kev ua ub no) kom tsis txhob impurities (xws li, muaj feem xyuam rau cov tshuaj steroids xws li prednisone) uas yuav cuam tshuam potency los yog ua rau muaj kev phiv tshuaj.
Txheej txheem ntau lawm: Ua nyob rau hauv GMP-cov ntaub ntawv pov thawj kev cob qhia, nrog kev tswj nruj ntawm cov tshuaj tiv thaiv, kev huv huv (xws li, kab chromatography), thiab crystallization los xyuas kom meej cov khoom ruaj khov, uniformity, thiab cov tshuaj ua haujlwm zoo ib yam.
Kev Ntsuas Cov Cai: Txhua batch tau txais kev sim ua tiav, suav nrog:
HPLC tsom xam rau purity thiab lwm yam tshuaj (ib impurity Tsawg dua los yog sib npaug rau 1.0%, tag nrho impurities Tsawg dua los yog sib npaug rau 3.0%)
Kev txiav txim siab melting point (225-231 degree, nrog decomposition)
Kev sib hloov kho qhov muag tshwj xeeb (-102℃rau -112 degree, hauv dioxane)
Heavy hlau (Pb, Hg, Cd) thiab kuaj microbial txwv
Kev kuaj tsis muaj menyuam (rau txhaj tshuaj - qib raw khoom)
Kev ceeb toom kev nyab xeeb:
Kev siv lub sijhawm ntev - siv sijhawm ntev tuaj yeem ua rau Cushing's syndrome (lub hli lub ntsej muag, truncal rog), hyperglycemia, osteoporosis, lossis kev tiv thaiv kab mob - yuav tsum tau muab tshuaj los ntawm kws kho mob, nrog ntau npaum li cas maj mam kom tsis txhob muaj adrenal tsis txaus.
Kev siv tshuaj pleev xim rau thaj chaw loj lossis cov tawv nqaij tawg tuaj yeem ua rau lub cev nqus; zam kev siv ntev ntawm lub ntsej muag lossis thaj chaw intertriginous (piv txwv li, armpits, puab tais) kom txo tau cov tawv nqaij atrophy.
Contraindicated nyob rau hauv cov neeg mob uas muaj cov kab mob nquag (xws li, tsis kho tuberculosis, kab mob hnyav / kab mob sib kis) tshwj tsis yog ua ke nrog kev kho mob antimicrobial.
Kev koom tes & kev sib cuag
Peb muab tshuaj -qib Prednisolone raw cov ntaub ntawv rau manufacturers ntawm qhov ncauj, txhaj tshuaj, tshuaj pleev ib ce, ophthalmic, thiab inhalation formulations, nrog saj zawg zog peev xwm (los ntawm gram- qib R & D cov qauv mus rau kilogram- theem bulk xaj). Yog tias koj yog ib lub tuam txhab kws tshuaj, R & D lub koom haum, lossis tus tsim qauv xav tau cov khoom no, thov hu rau peb rau:
Cov ntaub ntawv qhia txog kev ua raws cai pharmacopoeia (piv txwv li, USP monograph lees paub)
Tus nqi, kev txiav txim ntau luv nqi, thiab cov qauv thov
Kev pab txhawb nqa (piv txwv li, formulation compatibility, stability kev tshawb fawb)
Cov ntaub ntawv tiv tauj:
Email: sales@huarongpharma.com
Xov tooj/WhatsApp: +86 13751168070
Peb ua raws li cov hauv paus ntsiab lus ntawm "kev ua tau zoo ua ntej, ua raws li- taw qhia" thiab tos ntsoov yuav tsim kom muaj kev sib raug zoo ntev -, kev sib raug zoo nrog kev sib raug zoo nrog cov neeg koom tes thoob ntiaj teb!
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Cim npe nrov: Tuam Tshoj Prednisolone CAS 50-24-8 manufacturers, lwm tus neeg
