Product Description

Moxidectin, nrog rau tus lej sau npe tshuaj CAS#113507-06-5, yog cov tshuaj tiv thaiv kab mob muaj zog uas tau txais kev saib xyuas zoo hauv kev kho tsiaj thiab tsiaj txhu.

Chemical Structure thiab Properties

Moxidectin yog ib qho macrocyclic lactone compound uas yog nyob rau hauv chav kawm milbemycin ntawm cov tshuaj tiv thaiv kab mob. Nws muaj cov qauv tshuaj complex uas muaj lub nplhaib loj lactone nrog ntau pawg ua haujlwm txuas nrog.

Nyob rau hauv cov nqe lus ntawm lub cev muaj zog, moxidectin yog ib tug dawb mus rau dawb crystalline hmoov. Nws yog me ntsis soluble hauv dej tab sis ntau soluble hauv cov kuab tshuaj organic xws li methanol thiab ethanol. Moxidectin muaj lub siab melting point thiab ruaj khov nyob rau hauv ib txwm cia tej yam kev mob.

Mechanism ntawm Action

Moxidectin ua los ntawm kev cuam tshuam nrog cov hlab ntsha ntawm cov kab mob parasites. Nws khi rau cov receptors tshwj xeeb hauv cov kab mob cab cov paj hlwb, ua rau muaj kev nce hauv permeability ntawm cell membranes rau chloride ions. Qhov no ua rau hyperpolarization ntawm cov paj hlwb thiab tuag tes tuag taw ntawm cov cab.

Cov tshuaj muaj txiaj ntsig zoo tiv thaiv ntau yam kab mob sab hauv thiab sab nraud, suav nrog cov kab mob sib kis, kab mob sib kis, kab mob npaws, kab mob plawv, thiab qee hom kab mob thiab zuam. Moxidectin muaj lub sijhawm ntev ntawm kev ua haujlwm, muab kev tiv thaiv txuas ntxiv tiv thaiv kab mob parasitic.

Pharmacokinetics

Thaum muab tshuaj los ntawm qhov ncauj lossis txhaj tshuaj, moxidectin tau nqus sai sai ntawm lub plab zom mov lossis qhov chaw txhaj tshuaj. Tom qab ntawd cov tshuaj tau muab faib thoob plaws hauv lub cev, mus txog qhov siab ntawm cov ntaub so ntswg xws li lub siab, lub ntsws, thiab lub raum. Moxidectin muaj ib nrab-lub neej ntev, uas tso cai rau ncua sij hawm ntawm kev ua ub no thiab txo qhov zaus ntawm koob tshuaj.

Cov tshuaj yog metabolized nyob rau hauv daim siab thiab excreted feem ntau nyob rau hauv cov quav. Qee cov metabolites kuj yuav raug tso tawm hauv cov zis. Cov tshuaj pharmacokinetics ntawm moxidectin tuaj yeem sib txawv nyob ntawm seb yam xws li hom tsiaj, hnub nyoog, qhov hnyav, thiab kev noj qab haus huv.

Kev siv kho mob

Parasite Control nyob rau hauv Tsiaj txhu

Moxidectin yog siv dav hauv kev kho thiab tiv thaiv kab mob cab hauv cov tsiaj txhu xws li nyuj, yaj, thiab tshis. Nws tuaj yeem muab tshuaj los ntawm qhov ncauj lossis los ntawm kev txhaj tshuaj los tswj cov kab mob hauv lub cev xws li kab mob sib kis, kab mob sib kis, thiab kab mob npaws. Moxidectin tseem muaj txiaj ntsig zoo rau cov kab mob sab nraud xws li zuam thiab mites, pab txhim kho kev noj qab haus huv thiab tsim khoom ntawm cov tsiaj nyeg.

Khuv Xim Tsiaj

Hauv cov tsiaj sib koom xws li dev thiab miv, moxidectin yog siv rau kev tiv thaiv thiab kho kab mob plawv, nrog rau kev tswj hwm ntawm lwm yam kab mob sab hauv thiab sab nraud. Nws muaj nyob rau hauv ntau yam formulations, nrog rau cov ntsiav tshuaj, chewable ntsiav tshuaj, thiab tshuaj pleev ib ce, ua rau nws yooj yim rau cov tswv tsiaj los tswj.

Equine Health

Moxidectin kuj tseem siv rau hauv nees rau kev tswj cov kab mob cab. Nws tuaj yeem muab tshuaj los ntawm qhov ncauj lossis los ntawm kev txhaj tshuaj los kho thiab tiv thaiv cov kab mob hauv lub cev xws li cov kab mob sib kis thiab cov muaj zog. Moxidectin muaj txiaj ntsig zoo rau ntau hom kab mob parasite thiab feem ntau siv nrog rau lwm cov tshuaj tiv thaiv kab mob rau kev tiv thaiv kab mob.

Kev nyab xeeb thiab kam rau ua

Moxidectin feem ntau suav hais tias muaj kev nyab xeeb thiab zoo rau cov tsiaj. Txawm li cas los xij, zoo li txhua yam tshuaj, nws tuaj yeem ua rau muaj kev phiv rau qee tus neeg. Cov kev mob tshwm sim feem ntau muaj xws li ntuav, raws plab, tsis qab los noj mov, thiab lethargy. Cov kev mob tshwm sim no feem ntau yog mob me me thiab txwv tus kheej.

Muaj tsawg zaus, cov kev mob tshwm sim loj dua xws li kev tsis haum tshuaj, kev mob siab rau lub siab, lossis kev puas siab puas ntsws tuaj yeem tshwm sim. Nws yog ib qho tseem ceeb uas yuav tsum tau ua raws li cov lus pom zoo thiab kev tswj hwm cov lus qhia kom txo qis kev pheej hmoo ntawm kev phiv. Tsiaj txhu uas muaj lub siab ua ntej lossis kab mob raum yuav tsum tau ceev faj tshwj xeeb thiab saib xyuas kom zoo dua thaum noj moxidectin.

Kev tswj hwm thiab kev noj tshuaj

Moxidectin muaj nyob rau hauv ntau yam formulations, nrog rau cov ntsiav tshuaj, chewable ntsiav tshuaj, tshuaj pleev ib ce, thiab txhaj tshuaj. Txoj kev noj tshuaj thiab kev tswj hwm yog nyob ntawm hom tsiaj, hom kab mob cab uas raug kho, thiab qhov hnyav ntawm tus tsiaj.

Rau kev tswj hwm qhov ncauj, cov tshuaj feem ntau yog muab ua ib zaug xwb. Rau kev siv tshuaj pleev ib ce, kev daws teeb meem yog siv rau ntawm daim tawv nqaij tom qab ntawm caj dab. Kev txhaj tshuaj feem ntau yog muab intramuscularly lossis subcutaneously. Nws yog ib qho tseem ceeb uas yuav tau sab laj ib tus kws kho tsiaj kom paub meej cov lus qhia noj tshuaj kom raug thiab kom ntseeg tau tias siv cov tshuaj kom raug.

Xaus

Moxidectin yog cov tshuaj tiv thaiv kab mob zoo heev uas tau ua rau muaj txiaj ntsig zoo rau kev noj qab haus huv thiab kev noj qab haus huv ntawm cov tsiaj. Nws txoj haujlwm dav dav, lub sijhawm ntev ntawm kev ua haujlwm, thiab qhov profile muaj kev nyab xeeb ua rau nws muaj txiaj ntsig zoo hauv kev tawm tsam cov kab mob parasitic. Nrog rau kev tshawb fawb thiab kev txhim kho txuas ntxiv, moxidectin thiab lwm yam tshuaj tiv thaiv kab mob yuav txuas ntxiv txhim kho lub neej zoo rau cov tsiaj txhu thiab pab ua kom muaj kev ruaj khov ntawm cov tsiaj txhu thiab cov tsiaj txhu kev lag luam.

Cov ntaub ntawv tseem ceeb ntawm Moxidectin

Khoom npe	Moxidectin
CAS	113507-06-5
MF	C37 H53 N O8
MW	639.82
EINECS	635-129-7
Mol File	113507-06-5.mol

Moxidectin Cov Khoom Siv Tshuaj

Melting point	132 degree
Boiling point	79
Qhov ntom	1.23 ± 0.1 g / cm3 (Tshaj tawm)
Solubility	Ntau dua lossis sib npaug li 128 mg / mL hauv EtOH; Ntau dua lossis sib npaug rau 129.4 mg / mL hauv DMSO; Ntau tshaj los yog sib npaug rau 3.27 mg / mL hauv H2O nrog maj mam ua kom sov thiab ultrasonic
Daim ntawv	Khoom
Xim	Dawb mus Yuav luag dawb
Kev ruaj ntseg	Lub teeb Sensitive