Ciprofloxacin (CAS No.: 85721-33-}1) - Broad-Spectrum Fluoroquinolone Tshuaj tua kab mob rau cov kab mob hauv lub cev thiab hauv zos
Raws li tus kws tshaj lij kev lag luam ntawm cov tshuaj - qib tshuaj tua kab mob cov khoom xyaw, peb muab siab - purity Ciprofloxacin uas nruj me ntsis ua raws li cov qauv tshuaj pharmacopoeia thoob ntiaj teb (USP, EP, BP, CP). Thib ob - tiam fluoroquinolone, nws nthuav tawm cov kab mob muaj zog tiv thaiv ntau yam ntawm Gram-negative thiab Gram- cov kab mob zoo, suav nrog ntau hom tshuaj tiv thaiv kab mob ntau yam. Nws yog dav siv nyob rau hauvtib neeg tshuajrau kev kho cov kab mob hauv lub cev thiab hauv zos, thiab hauvkev xyaum ua tsiajrau kev tswj cov kab mob hauv cov tsiaj nyeg thiab aquaculture- ua rau nws yog lub hauv paus ntawm kev kho kab mob niaj hnub no.
Product Basic Information
| Yam khoom | Paub meej |
|---|---|
| Khoom npe | Ciprofloxacin |
| CAS Nr. | 85721-33-1 |
| Synonyms | 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; Cipro® (hom npe rau qhov ncauj / IV formulations) |
| Molecular Formula | C₁₇H₁₈FN₃O₃ |
| Molecular Luj | 331.34 |
| Qhov tshwm sim | Dawb mus rau me ntsis daj crystalline hmoov; Tsis hnov tsw |
| Specification | - Pharmaceutical Qib: Purity Ntau dua lossis sib npaug li 98.5% (HPLC); Kev sib hloov kho qhov muag tshwj xeeb []²⁰D 0℃± 1℃(hauv 0.1M HCl); Poob ntawm ziab Tsawg dua lossis sib npaug li 1.0%; Residue ntawm ignition Tsawg dua los yog sib npaug rau 0.1%; Cov hlau hnyav (Pb Tsawg dua lossis sib npaug rau 10ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug rau 1ppm)-Veterinary Qib: Purity Ntau dua lossis sib npaug li 95.0% (HPLC); Ua raws li EP Vet / USP Vet; Tsis pom muaj feem cuam tshuam txog quinolones (tsawg dua lossis sib npaug li 0.5%) |
| Melting Point | 255-257℃(nrog decomposition) |
| Solubility | me ntsis soluble hauv dej (≈2.5 g / L ntawm 25 degree); Soluble hauv acetic acid, dilute hydrochloric acid, thiab sodium hydroxide daws; Sparingly soluble hauv methanol |
| Kev cia khoom | Khaws rau hauv qhov txias (15-25 degree), qhuav, tiv thaiv lub teeb; Sealed los tiv thaiv kev nqus noo noo thiab photodegradation; Lub neej txee: 36 lub hlis rau qib kws kho mob, 24 lub hlis rau qib kws kho tsiaj |
Core Functions & Applications
Ciprofloxacin exerts nws cov kab mob bactericidal los ntawm inhibiting kab mob DNA gyrase (topoisomerase II) thiab topoisomerase IV-enzymes tseem ceeb rau cov kab mob DNA replication, transcription, thiab kho. Nws cov dej num yog concentration-dependent, nrog rau post- tshuaj tua kab mob nyhuv (PAE) uas inhibits cov kab mob regrowth tom qab cov tshuaj txo. Nws nthuav tawm dav -kev ua spectrum, tshwj xeeb tshaj yog tawm tsam Gram- cov kab mob tsis zoo (xws li,Escherichia coli, Pseudomonas aeruginosa) thiab xaiv Gram- cov kab mob zoo (piv txwv li,Staphylococcus aureus). Nws yog siv nyob rau hauv ob qho tib sitib neeg tshuajthiabkev xyaum ua tsiaj:
1. Human Pharmaceutical Field
1.1 Urinary Tract Infections (UTIs)
Uncomplicated UTIs: Thawj- kab mob cystitis tshwm sim los ntawmE. coli(tus kab mob feem ntau UTI). Qhov ncauj koob tshuaj: 250-500 mg ob zaug ib hnub rau 3-7 hnub, nrog rau kev kho mob ntau dua 90%.
Nyuaj UTIs & Pyelonephritis: Kho cov kab mob hnyav (xws li kab mob raum) tshwm sim los ntawm ntau yam tshuaj -resistantE. colilos yogKlebsiella pneumoniae. IV infusion (400 mg txhua 12 teev) thawj zaug, tom qab ntawd kho qhov ncauj (500-750 mg ob zaug ib hnub) rau 7-14 hnub.
1.2 Kab mob ua pa
Tsev Kho Mob -Tau mob ntsws (HAP): Siv rau HAP tshwm sim los ntawm Gram- cov kab mob tsis zoo (xws li,Pseudomonas aeruginosa, Enterobacterspp.) los yog methicillin-sensitiveS. aureus(MSSA). IV koob tshuaj: 400 mg txhua 8-12 teev rau 7-14 hnub, kho rau lub raum ua haujlwm.
Kab mob kab mob sinusitis: Kho cov kab mob tsis teb rau -lactams, tshwm sim los ntawmHemophilus influenzaelos yogMoraxella catarrhalis. Qhov ncauj koob tshuaj: 500 mg ob zaug ib hnub rau 10-14 hnub.
1.3 Lwm yam kab mob
Daim tawv nqaij & cov ntaub so ntswg mos: Siv tau rau cellulitis, abscesses, thiab qhov txhab kab mob tshwm sim los ntawmS. aureus(MSSA) lubPseudomonas aeruginosa. Qhov ncauj / IV koob tshuaj: 500-750 mg ob zaug ib hnub rau 7-14 hnub.
Kab mob plab: Kho cov neeg taug kev raws plab (ua los ntawm enterotoxigenicE. coli) thiab shigellosis (ua rauShigellaspp.). Qhov ncauj koob tshuaj: 500 mg ob zaug ib hnub rau 3-5 hnub, txo cov tsos mob ntev li 50%.
Anthrax Post-Kev Tiv Thaiv Kab Mob: Pom zoo los ntawm CDC rau kev tiv thaiv kab mob anthrax tom qab kis tauBacillus anthracis. Qhov ncauj koob tshuaj: 500 mg ob zaug ib hnub rau 60 hnub.
2. Veterinary teb
2.1 Tsiaj & Nqaij qaib
Cov kab mob ua pa:
Bovine respiratory disease (BRD) hauv nyuj (ua los ntawmMannheimia hemolytica, Pasteurella multocida): Kev txhaj tshuaj (2.5-5 mg / kg lub cev qhov hnyav, ib zaug ib hnub rau 3-5 hnub) lossis qhov ncauj premixes.
Avian colibacillosis hauv nqaij qaib (ua rauE. coli): Soluble hmoov (50-100 mg / kg pub) rau 3-5 hnub, txo cov neeg tuag nyob rau hauv cov kab mob.
Cov kab mob urinary & gastrointestinal:
Porcine cystitis (ua rauE. coli) thiab swine salmonellosis: Qhov ncauj koob tshuaj (10-15 mg / kg lub cev qhov hnyav txhua hnub) rau 5-7 hnub, txhim kho kev hloov pauv pub noj thiab txo qis cov kab mob.
2.2 Aquaculture
Kab Mob Kab Mob hauv Ntses & Cw:
Vibriosis nyob rau hauv marine ntses (xws li, salmon, hiav txwv bass) tshwm sim los ntawmVibrio anguillarum: Siv los ntawm kev pub (10-20 mg / kg lub cev qhov hnyav txhua hnub) rau 5-7 hnub, tswj kev tuag hauv cov pas dej aquaculture.
Aeromoniasis nyob rau hauv cov ntses dej tshiab (xws li, catfish, tilapia) tshwm sim los ntawmAeromonas hydrophila: da dej kho mob (5-10 mg/L dej) los yog pub additives, tiv thaiv daim tawv nqaij rwj thiab septicemia.
Quality & Safety Assurance
Ciprofloxacin kev siv thoob plaws xav tau kev tswj xyuas zoo kom ua tau zoo, txo qis kev tiv thaiv, thiab ua kom muaj kev nyab xeeb ntawm tib neeg thiab zaub mov- tsim cov tsiaj:
Raw Khoom & Synthesis: Ua los ntawm ntau- cov tshuaj synthesis (cyclization ntawm fluoroquinolone intermediates) ua raws li kev ua kom huv ntawm recrystallization. Cov ntaub ntawv nyoos ua tau raws li USP/EP cov qauv rau kev txwv tsis pub dhau (piv txwv li, desethylene ciprofloxacin Tsawg dua lossis sib npaug li 0.3%, cov khoom loj degradation).
Txheej txheem ntau lawm:
Pharmaceutical Qib: Ua nyob rau hauv GMP-cov kev cob qhia tau ntawv pov thawj (Class C cleanroom rau txhaj tshuaj- qib raw cov ntaub ntawv) nrog nruj tswj pH thiab kub los tiv thaiv racemization.
Veterinary Qib: Tau txais kev sim ntxiv rau kev nyab xeeb hauv dej (piv txwv li, tsis muaj cov tshuaj lom lom lom ua rau tsis zoo rau -cov kab mob hom phiaj) thiab ua raws li cov qauv kws kho tsiaj tsiaj.
Comprehensive Testing Protocol:
| Cov khoom kuaj | Txoj kev | Kev lees txais |
|---|---|---|
| Purity & Assay | HPLC (C18 kem, 278 nm nrhiav pom) | Pharmaceutical qib: Ntau dua lossis sib npaug rau 98.5% purity; Veterinary qib: Ntau dua lossis sib npaug rau 95.0% purity |
| Yam khoom muaj feem | HPLC (gradient elution) | Ib qho impurity Tsawg dua lossis sib npaug li 0.5%, tag nrho impurities Tsawg dua lossis sib npaug rau 1.0% |
| Hnyav Hlau | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pb Tsawg dua lossis sib npaug rau 10ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug rau 1ppm |
| Residue Solvents | GC (headspace sampling) | Acetonitrile Tsawg dua lossis sib npaug rau 410ppm, Ethanol Tsawg dua lossis sib npaug rau 5000ppm |
| Sterility (Tshwj xeeb txhaj tshuaj) | Membrane filtration method | Tsis muaj kab mob / fungal loj hlob |
Kev ceeb toom kev nyab xeeb:Tib neeg siv:
Contraindications: hypersensitivity rau fluoroquinolones; menyuam<18 years (risk of articular cartilage damage); pregnancy/lactation (Category C-potential fetal risk).
Cov teebmeem tsis zoo: Kev mob plab hnyuv, mob taub hau, kiv taub hau, thiab tsis tshua muaj tab sis mob hnyav (tshwj xeeb tshaj yog cov neeg laus lossis cov neeg noj corticosteroids). Tsis txhob raug tshav ntuj ntau dhau (photosensitivity txaus ntshai).
Kev siv Veterinary:
Lub Sijhawm Tshem Tawm: Nyuj: 14 hnub (nqaij), 48 teev (mis nyuj); Npua: 5 hnub (nqaij); Ntses: 300-500 degree-hnub (xws li dej kub × hnub).
Resistance ceeb toom: txwv tsis pub siv rau hauv cov tsiaj noj kom tsis txhob hla-ua pa nrog tib neeg cov kab mob (xws li,E. coli, Salmonella).
Kev koom tes & kev sib cuag
Peb muab Ciprofloxacin hauv ntau qib thiab cov qauv tsim kom tau raws li cov kev xav tau sib txawv:
Pharmaceutical Qib: Raw hmoov rau lub qhov ncauj ntsiav tshuaj, tshuaj ntsiav, IV txhaj, thiab tshuaj kho qhov muag (1kg-100kg ib qho kev txiav txim).
Veterinary Qib: Raw hmoov rau injectables, premixes, thiab aquaculture formulations (10kg-500kg ib qho kev txiav txim; txhua hli muaj peev xwm ntawm 1000kg).
Tus nqi - cov kev pabcuam ntxiv suav nrog:
Muab DMF (Drug Master File) thiab CEP (Certificate of Suitability) rau cov khoom siv tshuaj - qib los txhawb kev sau npe hauv EU, Asmeskas, thiab Asia.
Customized formulation kev them nyiaj yug (xws li, solubility txhim khu kev qha rau qhov ncauj ncua kev kawm ntawv, ruaj khov injectable daws rau cov tsiaj nyeg).
Kev taw qhia txog kev tswj hwm kev tiv thaiv (cov neeg siv tsiaj kho tsiaj) thiab kev hloov kho rau lub raum tsis zoo (cov neeg siv kev noj qab haus huv tib neeg).
Yog tias koj yog cov chaw tsim tshuaj, kws kho tsiaj, lossis cov chaw muag khoom hauv av, thov hu rau peb kom paub meej kev koom tes:
Cov ntaub ntawv tiv tauj:
Email: sales@huarongpharma.com
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Peb ua raws li cov hauv paus ntsiab lus ntawm "kev ua tau zoo, kev siv lub luag haujlwm, thiab kev koom tes ntev ntev" thiab tos ntsoov rau kev txhawb nqa thoob ntiaj teb kev noj qab haus huv thiab tsiaj noj qab haus huv cov thawj coj!
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