Vitamin B6 (CAS.: 8059-}}}}}}}}}}} {}}}} {}} oluble vitamin rau metabolic & Neurological
Raws li tus kws tshaj lij kev ua haujlwm ntawm cov kws ua tshuaj paus {{}}} {{{{{-}}}}}}}}}}}}}}}}}}}}}}}}}}}}} Nrog ntiaj teb cov qauv (USP, EP, FCC, GB). Ib qho dej tseem ceeb- soluble b} solivotal bitamin, nws plays} acid metabolism, neurotransmitter synthesis, thiab hemoglobin ntau lawm. Nws yog dav siv nyob rau hauvKws Tshuaj(rau kev kho tsis taus),Nutraceutical(rau kev noj zaub mov txhua hnub), thiabFelification fortification(Rau cov zaub mov enriched) -}}}} Txhawb tib neeg kev noj qab haus huv thoob plaws txhua pawg hnub nyoog.
Cov Khoom Siv Khoom Siv Khoom
| Yam | Cov ntsiab lus |
|---|---|
| Khoom npe | Vitamin B6 (Pyridoxine hydrochloride, cov ntawv lag luam tshaj plaws) |
| Cas Tsis tau. | 8059-24-3 (kev sib sau rau cov pawg B6 B6); Pyridoxine hydrochloride: 58-56-0 |
| Txhais lus hais tias | Pyridoxol; 3-hydroxy-4,5-BIS (hydroxymethyl) -2-methylpyridine; B6 vitamin |
| Molecular Cov Qauv | C₈₈₁₁₁₁₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃₃ h h h · Hydridoxine hydrochloride) |
| Molecular hnyav | 205.64 (Pyridoxine hydrochloride) |
| Kev tshwm sim | Dawb rau daj ntseg daj crystalline hmoov; Ntxhiab, nrog ib qho iab iab me ntsis saj |
| Kev qhia tshwj xeeb | - Kws Tshuaj Ntsuam Xyuas: Purity ntau dua los yog sib npaug rau 99.0% (HPLC); Assisy (raws li pyridoxine) ntau dua los yog sib npaug rau 82.3% (muaj txiaj ntsig ntawm lub hauv paus); Poob rau ziab qis dua lossis sib npaug rau 0.5%; Cov hlau hnyav (PB tsawg dua lossis sib npaug rau 10ppm, Hg tsawg dua lossis sib npaug ntawm 1PPM) {5 {5 5}}Nutraceutical / Zaub mov Qib Qib: Purity ntau dua los yog sib npaug rau 98.0% (HPLC); Ua raws li FCC / GB cov qauv; Tsis muaj cov tshuaj ntxiv) ntxiv |
| Melting point | 205-209℃(pyridoxine hydrochloride, nrog decomposition) |
| So | Dawb soluble hauv dej (ntau dua lossis sib npaug nrog 50 g / l ntawm 25 degree); Soluble hauv ethanol; Soluble me ntsis hauv acetone; Insoluble hauv ether, chloroform |
| Kev Cia | Khaws rau hauv qhov txias (15 {- 25 degree), qhuav, lub teeb-tiv thaiv lub thawv; Zam txhob kis qhov kub, noo noo, thiab kev tshav ntuj ncaj qha (tiv thaiv kev ua kom tsis txhob ua raws li); Txee Lub Neej: 36 lub hlis rau cov qhab nia ntawm Tshuaj, 24 lub hlis rau cov zaub mov / khoom noj khoom haus qib |
Core Functions & Cov Ntawv Thov
Vitamin B6 yog qhov tseem ceeb coenzyme rau ntau dua 100 enzymatic cov tshuaj tiv thaiv hauv tib neeg lub cev, feem ntau koom nrog hauvamino acid metabolism(Hloov pauv, kev txiav txim siab tsis sib xws),Neurotransmitter Synthesis(Serotonin, DOPAMINE, GABA),Heme Ntau Lawm(rau hemoglobin), thiabKev tiv thaiv kab mob tiv thaiv kab mobCov. Txij li thaum tib neeg lub cev tsis tuaj yeem suav nws, nws yuav tsum tau txais los ntawm cov khoom sab nraud. Nws tau thov rau hauv peb qhov tseem ceeb teb:
1. Kws Kho Mob Daim Duab (Kev Nyab Xeeb Kev Kho Mob & Kev Pab Txhawb Zoo)
1.1 Vitamin B6 tsis muaj peev xwm
Thawj qhov tsis txaus(Tsis tshua muaj, tshwm sim los ntawm cov tsos mob tsis txaus): Kho cov kab mob cheilos (paripheral (tingling hauv txhais tes / taw), thiab sidoBlastic anemia. Dosage: Qhov ncauj ntsiav tshuaj (25-100 mg txhua hnub) rau 4-8 lub lis piam kom txog thaum cov tsos mob daws.
Theem nrab tsis txaus(Ntau leej, tshwm sim los ntawm Malais-cawv, lossis siv yeeb tshuaj los ntawm cov tuberculaceation (50}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} Rau cov neeg siv isoniazid, concurrent b6 (10-50 mg txhua hnub) raug pom zoo kom tsis txhob siv cov tshuaj tsis txaus.
1.2 neurological discorders
Peripheral neuropathy: Kev kho kom raug kho rau cov neuropathy lossis tshuaj kho mob -} eg, los ntawm paclaaxel). Qhov Ncauj Dose: 100-300 mg txhua hnub (muab faib ua 3 koob tshuaj mob thiab kev ua kom zoo nkauj, feem ntau ua ke nrog lwm cov vitamins (B1, B12) rau cov teebmeem hauv sergistic.
Thaum sawv ntxov kev mob hauv cev xeeb tub: Muaj kev nyab xeeb rau kev kho mob xeev siab / ntuav hauv cev xeeb tub (thaum kev noj haus kev noj haus tsis haum). Cov tshuaj Dose: 10-25 mg Txhua 6-8 teev (max 100 mg txhua hnub); Kev zam cov tshuaj muaj kev pheej hmoo ntawm cov tshuaj tiv thaiv hauv cov tshuaj thaum ntxov cev xeeb tub.
1.3 hematological disorders
Sideroblastic me ntsis anemia: Kho kom raug B6-Teb Salteroblastic me me (tshwm sim los ntawm kev tsis zoo Heme synthesis) los ntawm kev rov ua haujlwm enzyme. Pib IV Koob tshuaj (100-200 mg
2. Nu txu teb (cov khoom noj khoom haus txhua hnub & kev txhawb nqa zoo)
Multivitamin pab: Ib qho tseem ceeb ntawm b - cov khoom lag luam (cov neeg muaj txiaj ntsig RDA: 1.3-1.7 mg / hnub rau cov poj niam).
Cov tshuaj tiv thaiv:
Rau cov neeg ncaws pob: Txhawb cov metabolism hauv cov metabolism thiab txo cov qoj ib ce - ua ke nrog B1, B2, thiab B3).
Rau Kev Pabcuam Teebmeem Kev Pab Cuam Tshuam Kev Pab Cuam Tshuam (vim nws lub luag haujlwm hauv Serotonin / Dopamine synthesis) hauv koob hnub 10-50 mg txhua hnub (hauv qab kev taw qhia).
Rau cov laus: tiv thaiv hnub nyoog -}}} Hais txog cov neeg laus vim tias txo kev ua haujlwm thiab kev tiv thaiv kev noj qab haus huv.
3. Cov zaub mov & dej haus teb (FORTICATION)
Txhim Kho Cov Khoom Noj: Ntxiv rau cereals (noj tshais (noj tshais, ncuav mog qab zib, thiab cov nplej zom thiab cov nplej zom txhua tus: 0.5-2 mg / 100g) los restore vitamins poob thaum ua tiav.
KEV LOM ZEM: Suav nrog cov dej haus, dej haus ua kis las, thiab kev noj haus huv (0.5}}}}}}}}}}}}
Cov Mis Mos: Manderatorily ntxiv rau cov mis mos (10-30 tus dab / 100 kcal) kom tau raws li cov kev xav tau khoom noj (uas tsis tuaj yeem tau txais B6 los ntawm cov zaub mov tawv).
Kev Ua Tau Zoo & Kev Tsim Kho Kev Nyab Xeeb
Raws li ib qho tseem ceeb ntawm cov zaub mov tseem ceeb nrog kev siv thoob plaws hauv chaw muag tshuaj, tshuaj ntsuab, thiab khoom noj, vitamin B6 yuav tsum muaj kev coj dawb huv, kev ruaj ntseg, thiab kev nyab xeeb:
Cov Khoom Siv Raw & Synthesis: Kev Lag Luam Vitamin B6 (Pyridoxine hydrochloride) yog tsim los ntawm kev ua yeeb yam tshuaj lom neeg (hws ntawm 4-methoxyde diethyl acetal) ua raws li los ntawm kev lim dej ntawm recrystallization. Cov ntaub ntawv nyoos ntsib USP / EP / FCC cov qauv rau impurity txwv (piv txwv li, muaj feem ntau pyridines tsawg dua los yog sib npaug 0.1%).
Cov txheej txheem ntau lawm:
Kws tsim khoom noj yog tsim los ntawm GMP {{}}}}}}}}}}}}}}} kev sib xyaw.
Nutraceutical / Zaub mov {{{{{{}}}} Cov kab mob ntsuas microbial tsawg dua lossis sib npaug nrog 100 cfu / g) kom tau raws li cov qauv kev nyab xeeb zaub mov.
Kev Ntsuas Xyuas Cov Quav:
| Ntsuas Yam | Txojkev | Kev lees txais cov txheej txheem |
|---|---|---|
| Purity & Assay | HPLC (C18, 280 nm nrhiav kom tau) | Kws tsim qauv qib: ntau dua los yog sib npaug ntawm 99.0% purity, ntau dua los yog sib npaug rau 82.3% pyridoxine; Nutraceutical Qib: ntau dua los yog sib npaug rau 98.0% purity |
| Lwm yam tshuaj | HPLC (Gradient Elfution) | Ib leeg impurity tsawg dua los yog sib npaug rau 0.1%, tag nrho cov impurities tsawg dua los yog sib npaug rau 0.5% |
| Cov hlau hnyav | ICP - ms (inductively coupled ntshav -} cov spectrometry) | PB tsawg dua lossis sib npaug rau 10ppm, Hg tsawg dua lossis sib npaug ntawm 1PPM, Cd tsawg dua lossis sib npaug lossis sib npaug |
| Cov me me paug | Phaj Suav Txoj Kev | Nutraceutical / Zaub mov qib: Tag nrho aerobic bacteria tsawg dua los yog sib npaug rau 1000 cfu / g, pwm tsawg dua lossis sib npaug nrog 100 cfu / g |
| Daim qhia npe | IR Spectroscopy & UV Kev Txhim Kho | Ntais ntawv siv hluav taws xob; UV Max ntawm 291 nm (hauv 0.1m hcl) |
Kev Nyab Xeeb Kev Nyab Xeeb:
Kev phom sij lom: Vitamin B6 is generally safe at recommended doses, but long-term high-dose use (>100 mg daily for >6 lub hlis) tej zaum yuav ua rau peripheral neuropathy (thim rov qab raws li koob tshuaj txo). Tsis txhob cia tus kheej -} Kev siv tshuaj nrog koob tshuaj ntau.
Yam sib pauv: Hypersensitivity rau pyridoxine lossis ib qho b6 derivatives; Tsis muaj lub paub medainsations ntawm RDA koob tshuaj.
Kev sib cuam tshuam yeeb tshuaj: Tej zaum cuam tshuam nrog levodopa (txo nws txoj kev ua tau zoo rau Parkinson tus kab mob) thiab qhov ncauj tiv thaiv (yuav nce B6 yuav tsum tau); Tham nrog tus kws kho mob yog tias siv cov tshuaj no.
Kev Koom Tes & Hu
Peb muab cov vitamin B6 hauv ntau qib thiab cov qauv kom tau raws kev sib txawv ntawm cov ntawv thov kev pab cuam tshuam:
Kws Tshuaj Ntsuam Xyuas: Cov hmoov nplej nyoos rau qhov ncauj ntsiav tshuaj, txhaj tshuaj, thiab cov creams (1kg-100kg ib qho kev txiav txim).
Nutraceutical / Zaub mov Qib Qib: Cov hmoov nplej nyoos, granulosulated hmoov (10kg-500kg ib zaug; txhua hli tsim khoom ntawm 2000kg
Tus nqi -} muaj kev pabcuam ntxiv nrog:
Muab DMF (cov ntaub ntawv siv tshuaj) rau cov khoom siv tshuaj) rau cov khoom lag luam qib kawm rau EU, peb, thiab Asia.
Customized qauv: microencapsulation (txhawm rau txhim kho kev ruaj khov nyob rau hauv high - sov zaub mov ua) thiab granulation (rau kev sib xyaw yooj yim (rau kev sib xyaw yooj yim).
Kev Txhawb Nqa: Cov Khoom Noj Khoom Noj Khoom Haus Kev Noj Qab Haus Huv (rau cov zaub mov / cov neeg siv khoom lag luam ntxiv) thiab cov neeg siv khoom lag luam kev ruaj ntseg).
Yog tias koj yog cov chaw tsim tshuaj paus, ntxiv hom, khoom noj khoom haus / dej qab zib tsim khoom, lossis lub tuam txhab tsis muaj npe, thov hu rau peb kom paub meej kev koom tes:
Cov ntaub ntawv tiv toj:
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Peb ua raws li cov ntsiab cai ntawm "kev coj dawb huv, ua raws li {}}}}}} {{{1} CENTAGE" thiab tos ntsoov koom tes nrog ntiaj teb kev noj qab haus huv thiab kev lag luam khoom noj khoom haus!
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