Ceftiofur (CAS No.: 80370-57-}6) - Third-Generation Cephalosporin Antibacterial for Veterinary Use
Raws li tus kws tshaj lij ntawm cov kws kho tsiaj- qib tshuaj tua kab mob cov khoom xyaw, peb muab siab -Ceftiofur purity uas nruj me ntsis raws li cov kws kho tsiaj thoob ntiaj teb (USP Vet, EP Vet, CP Vet). Ib qho thib peb - tiam ib nrab -synthetic cephalosporin, nws nthuav dav -spectrum bactericidal kev ua haujlwm tawm tsam Gram-positive thiab Gram-cov kab mob tsis zoo- suav nrog -lactamase- tsim cov kab mob. Tshwj xeeb raukev xyaum ua tsiaj, nws yog dav siv los kho cov kab mob hauv cov tsiaj nyeg (tua, npua, yaj) thiab cov tsiaj sib koom (dua, miv), ua tus neeg sawv cev tseem ceeb rau kev tswj cov kab mob ua pa, tso zis, thiab cov ntaub so ntswg mos thaum pab tsiaj noj qab haus huv thiab tsim khoom.
Product Basic Information
| Yam khoom | Paub meej |
|---|---|
| Khoom npe | Ceftiofur |
| CAS Nr. | 80370-57-6 |
| Synonyms | (6R,7R)-7-[[(2Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-3-[(2-furylcarbonyl)thiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2. Excenel® (lub npe tshuaj rau cov tshuaj kho tsiaj) |
| Molecular Formula | C₂₂H₁₉N₅O₇S₃ |
| Molecular Luj | 565.61 |
| Qhov tshwm sim | Dawb mus daj daj crystalline hmoov; Tsis muaj ntxhiab los yog nrog me ntsis cov yam ntxwv tsw |
| Specification | - Veterinary Qib: Purity Ntau dua lossis sib npaug li 95.0% (HPLC); Assay 900-1100 ug / mg (anhydrous hauv paus); Poob ntawm ziab Tsawg dua lossis sib npaug li 2.0%; Residue ntawm ignition Tsawg dua los yog sib npaug li 0.5%; Cov hlau hnyav (Pb Tsawg dua lossis sib npaug ntawm 10ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug li 1ppm); Cov kuab tshuaj seem (methanol Tsawg dua lossis sib npaug rau 300ppm, acetone Tsawg dua lossis sib npaug li 500ppm) |
| Melting Point | 170-175℃(nrog decomposition) |
| Solubility | me ntsis soluble hauv dej (≈5 mg / mL ntawm 25 degree); Soluble hauv dilute acids (piv txwv li, 0.1M HCl) thiab dilute alkali (piv txwv li, 0.1M NaOH); me ntsis soluble hauv methanol, ethanol; Insoluble hauv chloroform, ether |
| Kev cia khoom | Khaws rau hauv qhov txias (15-25 degree), qhuav, lub teeb -cov thawv tiv thaiv; Sealed los tiv thaiv kev nqus dej (hygroscopic) thiab degradation (rhiab rau lub teeb thiab kub kub); Tsis txhob sib cuag nrog cov oxidizing muaj zog; Lub neej txee: 24 lub hlis rau qib kws kho tsiaj |
Core Functions & Mechanism of Action
CAS # 80370-57-6 Nrbactericidal nyhuvlos ntawm kev cuam tshuam nrog cov kab mob cell phab ntsa synthesis-ua raws li cov txheej txheem ntawm cephalosporin- cov tshuaj tua kab mob hauv chav kawm, nrog rau qhov tseem ceeb ntawm cov kab mob veterinary:
Lub hom phiaj khi: Ceftiofur khi rau penicillin-binding proteins (PBPs) ntawm cov kab mob cell membrane. PBPs yog cov enzymes tseem ceeb rau kev hla - txuas peptidoglycan, cov pob txha pob txha ntawm cov kab mob ntawm cov phab ntsa.
Cell phab ntsa cuam tshuam: Los ntawm inhibiting PBP kev ua ub no, Ceftiofur tiv thaiv peptidoglycan cross- txuas, ua rau cov phab ntsa ntawm tes tsis muaj zog uas tsis tuaj yeem tiv taus osmotic siab.
Kab mob Lysis: Weakened cell phab ntsa rupture, ua rau cov kab mob hlwb lyse (tuag).
Qhov tseem ceeb antibacterial spectrum zoo rau kev siv veterinary:
Gram{0}}Cov kev pab tsis zoo: Muaj zog tiv thaiv cov kab mob veterinary zoo liMannheimia hemolytica, Pasteurella multocida, Hemophilus somni(cov nyuj),Actinobacillus pleuropneumoniae yog cov kab mob, Escherichia coli( npua), thiabProteus mirabilis( dev ).
Gram{0}}Cov Kev Pab Zoo: Inhibits susceptibleStaphylococcus aureus(MSSA),Streptococcus ua( npua), thiabStreptococcus kab mob( dev ).
-Lactamase Stability: Resistant mus rau feem ntau cov kab mob -lactamases (enzymes uas inactivate cephalosporins), ua rau nws zoo tiv thaiv -lactam- resistant hom kab mob nyob rau hauv cov tsiaj nyeg.
Core Applications (Veterinary Field)
Ceftiofur CAS # 80370-57-6 yog tswj los ntawmtxhaj tshuaj (IM, SC)los yogqhov ncauj formulations(rau cov hom tshwj xeeb) thiab tau tshwj tseg rau kev kho cov kab mob kab mob hauv cov tsiaj-tsis siv rau tib neeg. Dosing txawv ntawm hom thiab hom kab mob:
1. Tsiaj (Nyob, Npua, Yaj)
1.1 Tsi
Bovine Respiratory Disease (BRD): Cov lus qhia ntau tshaj plaws - kho cov kab mob tshwm sim los ntawmMannheimia hemolytica, Pasteurella multocida, los yogHemophilus somni(shipping kub). IM/SC koob tshuaj: 1.1–2.2 mg/kg lub cev hnyav ib hnub rau 3–5 hnub.
Bovine Metritis: Kho tom qab-mob uterine kab mob tshwm sim los ntawmE. colilos yogArcanobacterium pyogenes. koob tshuaj IM: 2.2 mg / kg ib hnub ib zaug rau 3-5 hnub.
Ko Taw Rot: Rau kab mob ko taw (piv txwv li,Fusobacterium necrophorum). IM koob tshuaj: 2.2 mg / kg ib hnub ib zaug rau 3 hnub.
1.2 npua
Porcine Respiratory Disease Complex (PRDC): Kho kab mob los ntawmActinobacillus pleuropneumoniae yog cov kab mob, Pasteurella multocida, los yogStreptococcus ua. koob tshuaj IM: 3-5 mg / kg ib hnub ib zaug rau 3-5 hnub.
Porcine Septicemia: RauE. colilos yogSalmonella-ua rau muaj kab mob ntshav hauv cov npua. koob tshuaj IM: 5 mg / kg ib hnub ib zaug rau 3 hnub.
Swine Dysentery: Adjuvant Therapy rauBrachiispira hyodysenteriakab mob (ua ke nrog lwm cov tshuaj tua kab mob). koob tshuaj IM: 3 mg / kg ib hnub ib zaug rau 3 hnub.
1.3 Yaj
Ovine Respiratory Disease: KhoPasteurella multocidalos yogMannheimia hemolyticakab mob. koob tshuaj IM: 2.2 mg / kg ib hnub ib zaug rau 3-5 hnub.
Ovine Mastitis: Rau cov kab mob udder tshwm sim los ntawmStaphylococcus aureuslos yogE. coli. IM koob tshuaj: 2.2 mg / kg ib hnub ib zaug rau 3 hnub.
2. Cov Tsiaj Tsiaj (Aub, Tsiaj)
Daim tawv nqaij & cov ntaub so ntswg mos: Kho pyoderma, abscesses, los yog cellulitis tshwm sim los ntawmStaphylococcus pseudintermediauslos yogE. coli. SC koob tshuaj: 5-10 mg / kg ib hnub ib zaug rau 5-7 hnub.
Urinary Tract Infections (UTIs): RauE. coli, Proteus mirabilis, los yogKlebsiella pneumoniaekab mob. SC koob tshuaj: 5-10 mg / kg ib hnub ib zaug rau 7-10 hnub.
Cov kab mob ua pa: Kho cov kab mob rhinitis los yog bronchitis tshwm sim los ntawmBordetella bronchisepticalos yogPasteurella multocida. SC koob tshuaj: 5-10 mg / kg ib hnub ib zaug rau 5-7 hnub.
3. Contraindications
Tsis txhob siv rau hauv cov tsiaj hypersensitive rau cephalosporins los yog penicillins (cross-kev pheej hmoo ua xua).
Tsis txhob siv rau hauv nteg qe (xws li residue txaus ntshai) los yog cov nyuj uas tsim cov mis nyuj rau tib neeg noj (mis nyuj residue txaus ntshai).
Tsis txhob siv rau hauv cov tsiaj yug me nyuam (hnub nyoog qis dua 7 hnub) tshwj tsis yog qhia los ntawm kws kho tsiaj (qhov ua rau lub raum tsis zoo ua rau muaj kev phom sij).
Quality & Safety Assurance
Raws li kws kho tsiaj cov tshuaj tua kab mob tseem ceeb rau tsiaj noj qab haus huv thiab kev nyab xeeb zaub mov, Ceftiofur xav tau kev tswj xyuas nruj kom ntseeg tau tias muaj zog, purity, thiab ua raws li cov kev txwv seem:
1. Kev tsim khoom & Purity Control
Synthesis: Ua los ntawm semi-synthetic hloov kho ntawm 7-ACA (7-aminocephalosporanic acid), nrog rau cov kauj ruam tseem ceeb suav nrog acylation (ntxiv cov aminothiazole sab saw) thiab thiomethylation (ua cov furylcarbonyl pawg). Cov txheej txheem kom ntseeg tau tias:
Tsawg impurities (piv txwv li, 7-ACA derivatives, degradation khoom) Tsawg dua los yog sib npaug li 2.0% (tag nrho impurities);
Raws li -lactam nplhaib kev ncaj ncees (tseem ceeb rau kev ua haujlwm ntawm cov kab mob), tau txheeb xyuas los ntawm HPLC.
Ua raws li GMP: Tsim nyob rau hauv Qib D cleanrooms (raws li ICH Q7 Vet cov lus qhia) nrog kev tswj nruj ntawm cov kab mob microbial (tag nrho aerobic suav Tsawg dua lossis sib npaug li 100 CFU / g) thiab qib endotoxin (tsawg dua lossis sib npaug li 5 EU / mg rau cov tshuaj txhaj tshuaj).
2. Cov Txheej Txheem Kev Ntsuas Zoo
| Cov khoom kuaj | Txoj kev | Kev lees txais |
|---|---|---|
| Purity & Assay | HPLC (C18 kem, 254 nm nrhiav pom) | Purity Ntau dua lossis sib npaug li 95.0%; Assay 900–1100 ug/mg |
| Yam khoom muaj feem | HPLC (gradient elution) | Ib qho impurity Tsawg dua lossis sib npaug li 1.0%; Tag nrho impurities Tsawg dua lossis sib npaug li 2.0% |
| Hnyav Hlau | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pb Tsawg dua lossis sib npaug rau 10ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug rau 1ppm |
| Residual Solvents | GC (headspace sampling, FID ntes) | Chav kawm 2 cov kuab tshuaj tsawg dua lossis sib npaug ntawm 500ppm; Cov kuab tshuaj Class 1 tsis kuaj |
| Poob rau ziab | Gravimetric method (105℃rau 2 teev) | Tsawg dua lossis sib npaug li 2.0% |
| Residue ntawm Ignition | Tshav kub ntawm 600 degree | Tsawg dua los yog sib npaug li 0.5% |
| Microbial Contamination | Phaj suav txoj kev | Tag nrho aerobic suav Tsawg dua lossis sib npaug rau 100 CFU / g; Tsis pom muaj kab mob (E. coli, Salmonella) |
3. Kev ceeb toom txog kev nyab xeeb & seem
Kev Nyab Xeeb Tsiaj:
Cov teebmeem tshwm sim tsis tshua muaj tab sis yuav suav nrog qhov chaw txhaj tshuaj hauv zos (o, mob) lossis mob plab hnyuv (mob plab) hauv dev / miv.
Kev noj tshuaj ntau dhau tuaj yeem ua rau muaj kev puas tsuaj rau neurotoxicity (tremors, qaug dab peg) hauv cov tsiaj me -ua raws li cov koob tshuaj pom zoo.
Kev Nyab Xeeb Khoom Noj (Cov Tsiaj Tsiaj):Lub Sijhawm rho nyiaj: Tseem ceeb los tiv thaiv cov tshuaj tua kab mob seem hauv cov khoom tsiaj:
nyuj: 14 hnub (nqaij), 48 teev (mis nyuj, yog pom zoo rau lactating nyuj);
Npua: 5 hnub (nqaij);
Yaj: 10 hnub (nqaij).
Kev Ntsuas Cov Khoom Siv: Ua raws li MRLs (Cov Kev Cai Lij Choj Ntau Tshaj) tau teeb tsa los ntawm Codex Alimentarius (piv txwv li, 100 ug / kg rau ceftiofur residues hauv cov nqaij nyuj).
Kev koom tes & kev sib cuag
Peb muab cov kws kho tsiaj-qib CAS# 80370-57-6 rau hauv cov ntaub ntawv uas haum rau cov tsiaj ntawv tshwj xeeb:
Veterinary Injectable Qib: Cov hmoov zoo (1kg-50kg ib qho kev txiav txim, ntim cov hnab ntawv txhuas nrog cov desiccants) rau kev kho dua tshiab rau hauv IM / SC txhaj tshuaj.
Veterinary Oral Qib: Granules (10kg-200kg ib qho kev txiav txim) rau qhov ncauj premixes (ntxiv rau pub / dej rau npua / yaj).
Tus nqi - cov kev pabcuam ntxiv suav nrog:
MuabVeterinary Drug Master File (V-DMF)los txhawb kev tswj cov ntaub ntawv hauv kev lag luam thoob ntiaj teb (US FDA CVM, EU EMA, Tuam Tshoj NMPA).
Kev txhawb nqa kev tsim kho kev tsim kho (xws li, kev txhim kho kev ua kom zoo rau kev txhaj tshuaj, kev ntsuas kev ruaj ntseg rau premixes).
Batch- tshwj xeebCOA (Certificate of Analysis)nrog rau cov txiaj ntsig ntawm kev soj ntsuam seem kom ntseeg tau tias ua raws li cov cai tswj kev nyab xeeb ntawm zaub mov.
Yog tias koj yog cov chaw tsim tshuaj tua tsiaj, chaw muag tshuaj tsiaj tsiaj, lossis tsiaj noj qab haus huv kev lag luam, thov hu rau peb kom paub meej kev koom tes:
Cov ntaub ntawv tiv tauj:
Email: sales@huarongpharma.com
Xov tooj/WhatsApp: +86 13751168070
Peb ua raws li cov hauv paus ntsiab lus ntawm "kev ua tau zoo ntawm kws kho tsiaj, kev nyab xeeb zaub mov, thiab kev tswj hwm kev ua raws cai" thiab tos ntsoov rau kev koom tes nrog kev lag luam tsiaj ntiaj teb kev noj qab haus huv!
Cim npe nrov: Suav teb ceftiofur cas# 80370-57-6 manufacturers, lwm tus neeg
