Thioctic Acid (CAS No.: 62-46-4) - Ntuj Antioxidant & Coenzyme rau Kev Txhawb Metabolic
Raws li tus kws tshaj lij kev lag luam ntawm cov kws kho mob -qib, nutraceutical- qib, thiab tshuaj pleev ib ce- qib cov khoom xyaw, peb muab siab - purity Thioctic Acid (tseem hu ua Alpha-Lipoic Acid, ALA) uas ua raws li cov qauv thoob ntiaj teb (USP, FCC EP, B). Ib txwm tshwm sim organosulfur compound, nws ua raws li ob qho tib si amuaj zog antioxidantthiab atseem ceeb coenzymehauv cellular zog metabolism. Nws lub peev xwm tshwj xeeb txhawm rau tshem tawm cov dawb radicals hauv dej -soluble thiab rog-soluble ib puag ncig, ntxiv rau nws lub luag haujlwm hauv kev rov tsim dua lwm cov antioxidants (xws li vitamin C, vitamin E), ua rau nws siv dav hauvtib neeg tshuaj(rau cov kab mob metabolic),nutraceuticals(rau kev txhawb nqa antioxidant), thiabtshuaj pleev ib ce(rau cov tshuaj tiv thaiv- kev laus).
Product Basic Information
| Yam khoom | Paub meej |
|---|---|
| Khoom npe | Thioctic Acid (Alpha-Lipoic Acid, ALA) |
| CAS Nr. | 62-46-4 |
| Synonyms | 5-(1,2-Dithiolan-3-yl) pentanoic acid; - lipoic acid; Lipoic acid |
| Molecular Formula | C₈H₁₄O₂S₂ |
| Molecular Luj | 206.32 |
| Qhov tshwm sim | daj mus daj daj crystalline hmoov; Tsis muaj ntxhiab tsw lossis nrog cov yam ntxwv me ntsis sulfur-zoo li tsw |
| Specification | - Pharmaceutical Qib: Purity Ntau dua lossis sib npaug li 99.0% (HPLC); Kev ntsuas 98.0% - 102.0%; Melting point 60-62 degree; Poob ntawm ziab Tsawg dua lossis sib npaug li 0.5%; Cov hlau hnyav (Pb Tsawg dua lossis sib npaug ntawm 5ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug li 1ppm); Cov kuab tshuaj seem (ethanol Tsawg dua lossis sib npaug li 500ppm, acetone Tsawg dua lossis sib npaug li 500ppm)-Nutraceutical Qib: Purity Ntau dua lossis sib npaug li 98.0% (HPLC); Kev ntsuas 97.0% -103.0%; Cov hlau hnyav tsawg dua lossis sib npaug rau 10ppm-Qib Tshuaj pleev ib ce: Purity Ntau dua lossis sib npaug li 97.0% (HPLC); Cov hlau hnyav tsawg dua lossis sib npaug li 20ppm |
| Melting Point | 60-62 degree |
| Solubility | me ntsis soluble hauv dej (≈1 g / L ntawm 25 degree); Soluble hauv ethanol (≈200 g / L), methanol, chloroform, thiab zaub roj; Insoluble hauv hexane |
| Kev cia khoom | Khaws rau hauv qhov txias (15-25 degree), qhuav, lub teeb -cov thawv tiv thaiv; Muab kaw los tiv thaiv oxidation (sulfur pawg yog huab cua-sensitive) thiab nqus dej noo; Tsis txhob sib cuag nrog cov oxidizing muaj zog; Lub neej txee: 36 lub hlis rau qib tshuaj, 24 lub hlis rau nutraceutical / cosmetic qib |
Core Functions & Mechanism of Action
62-46-4 exerts dual lub luag haujlwm tseem ceeb-kev ua haujlwm ntawm coenzymenyob rau hauv lub zog metabolism thiabkev ua haujlwm antioxidantnyob rau hauv dawb radical scavenging- ua rau nws muaj ntau yam bioactive compound:
1. Coenzyme hauv Cellular Zog Metabolism
Thioctic Acid 62-46-4 yog ib qho tseem ceeb cofactor rau covpyruvate dehydrogenase complex (PDHC)thiab-ketoglutarate dehydrogenase complex-ob lub enzymes tseem ceeb hauv mitochondria (cellular "powerhouses"):
Cov complexes no hloov cov pyruvate (los ntawm cov piam thaj tawg) thiab -ketoglutarate (los ntawm lub voj voog Krebs) rau hauv acetyl-CoA thiab succinyl-CoA, raws li.
Cov txheej txheem no tseem ceeb heev rau kev tsim cov adenosine triphosphate (ATP), thawj lub zog txiaj ntawm cov hlwb.
Hauv cov kab mob metabolic (piv txwv li, ntshav qab zib neuropathy), 62-46-4 pab rov ua haujlwm mitochondrial, txhim kho lub zog hauv cov hlwb puas.
2. Muaj zog Antioxidant Activity
Tsis zoo li feem ntau cov tshuaj antioxidants (uas yog dej-soluble lossis rog-soluble), Thioctic Acid 62-46-4 yogamphiphilic-nws ua haujlwm hauv ob lub cellular daim nyias nyias (rog-ib puag ncig soluble) thiab cytoplasm (dej-ib puag ncig soluble):
Dawb Radical Scavenging: Neutralizes reactive oxygen hom (ROS, piv txwv li, superoxide, hydroxyl radicals) thiab reactive nitrogen hom (RNS, piv txwv li, nitric oxide), txo oxidative kev nyuaj siab.
Antioxidant Regeneration: Recycles depleted antioxidants zoo li vitamin C, vitamin E, glutathione, thiab coenzyme Q10 rov qab rau lawv cov ntaub ntawv nquag, amplifying lub cev lub ntuj antioxidant tiv thaiv.
Hlau Chelation: khi rau cov hlau hnyav (piv txwv li, txhuas, mercury, tooj liab), tiv thaiv lawv los ntawm kev tsim cov dawb radicals thiab pab txhawb lawv cov excretion.
Cov ntawv thov tseem ceeb
cas 62-46-4's multi-functional zog ua rau nws haum rau kev lag luam tshuaj, nutraceutical, thiab tshuaj pleev ib ce:
1. Pharmaceutical teb
Feem ntau siv rau kev kho mobmetabolic thiab oxidative kev nyuaj siab- cuam tshuam:
1.1 Diabetic Neuropathy
Qhov zoo tshaj plaws -tsim kho kev siv-cas 62-46-4 txhim kho cov paj hlwb thiab txo cov tsos mob (mob, loog, tingling) hauv cov neeg mob ntshav qab zib peripheral neuropathy:
IV Administration: 600 mg ib zaug ib hnub rau 3 lub lis piam (induction theem), ua raws li kev kho qhov ncauj (600 mg ib hnub ib zaug) rau 4-6 lub hlis.
Mechanism: Txo oxidative kev nyuaj siab nyob rau hauv paj hlwb, txhim kho microcirculation, thiab restores hlab ntsha conduction tshaj tawm.
1.2 Cov kab mob siab
Siv los ua kev kho mob ntxiv rau cov kab mob siab cawv thiab tsis yog -alcoholic fatty siab kab mob (NAFLD):
Qhov ncauj koob tshuaj: 600-1200 mg ib hnub twg rau 3-6 lub hlis.
Mechanism: Tshem tawm cov dawb radicals nyob rau hauv daim siab hlwb, txo lipid peroxidation, thiab txhawb lub siab detoxification txoj kev.
1.3 Lwm yam mob metabolic
Insulin Resistance: Tej zaum yuav txhim kho kev nkag siab ntawm insulin los ntawm kev txo qis oxidative kev nyuaj siab hauv pancreatic beta hlwb (kev tshawb fawb siv, koob tshuaj: 600-1200 mg txhua hnub).
Hnub nyoog-Txog Kev Paub Tsis Txaus Siab: Adjuvant siv los txo oxidative kev nyuaj siab nyob rau hauv lub hlwb (kev soj ntsuam kev sim tsis tu ncua, koob tshuaj: 600–1200 mg ib hnub twg).
2. Nutraceutical teb
Dav siv nyob rau hauv cov khoom noj khoom haus ntxiv rauantioxidant txhawb thiab metabolic kev noj qab haus huv:
Antioxidant Formula: Ua ke nrog cov vitamins C/E, glutathione, los yog coenzyme Q10 los txhim kho cov dawb radical scavenging (ib hnub koob tshuaj: 100–600 mg).
Ntshav Qab Zib Txhawb: Ntxiv rau cov tshuaj ntxiv rau cov neeg mob ntshav qab zib ua ntej lossis cov neeg mob ntshav qab zib mellitus los txhawb kev ua haujlwm ntawm insulin (kwv yees txhua hnub: 300–600 mg).
Anti-Aging Supplements: Ua lag luam rau kev tiv thaiv cellular tiv thaiv hnub nyoog- cuam tshuam txog kev puas tsuaj oxidative ( noj txhua hnub: 100–300 mg).
3. Kho kom zoo nkauj teb
Incorporated rau hauv cov khoom siv tawv nqaij raulos tiv thaiv -aging thiab brightening teebmeem:
Anti-Aging Serums/Creams: Txo cov oxidative kev nyuaj siab nyob rau hauv daim tawv nqaij, txo cov kab zoo thiab wrinkles, thiab tiv thaiv UV-induced puas tsuaj (ntau npaum li cas: 0.5%–2%).
Daim tawv nqaij Brightening khoom: inhibits melanin ntau lawm los ntawm chelating tooj liab (ib cofactor rau tyrosinase, enzyme tseem ceeb hauv melanin synthesis), txo qhov tsaus me ntsis thiab hyperpigmentation (concentration: 1% -3%).
Antioxidant Primers: Tsim ib txheej tiv thaiv ntawm daim tawv nqaij, neutralizing dawb radicals los ntawm cov pa phem thiab ib puag ncig stressors.
Quality & Safety Assurance
Raws li ntau- cov khoom siv hauv kev lag luam, Thioctic Acid yuav tsum muaj kev tswj hwm nruj raws li nws daim ntawv thov:
1. Kev tsim khoom & Purity Control
Synthesis: Ua los ntawm cov tshuaj synthesis (xws li, condensation ntawm 6,8-dichloro-octanoic acid nrog sodium sulfide) los yog microbial fermentation (rau natural-source ALA). Cov txheej txheem kom ntseeg tau tias:
High optical purity (rau kev siv tshuaj, lub ntuj R-enantiomer yog nyiam, txawm tias racemic sib tov yog siv nyob rau hauv nutraceuticals / tshuaj pleev ib ce);
Tsawg impurities (piv txwv li, disulfide byproducts) Tsawg dua lossis sib npaug li 0.5% (qib tshuaj).
Ua raws li GMP: Pharmaceutical-qib Thioctic Acid yog tsim nyob rau hauv Qib D cleanrooms (raws li ICH Q7 cov lus qhia); nutraceutical / cosmetic qib ua raws li GMP rau cov khoom noj / tshuaj pleev ib ce.
2. Cov Txheej Txheem Kev Ntsuas Zoo
| Cov khoom kuaj | Txoj kev | Kev lees txais |
|---|---|---|
| Purity & Assay | HPLC (C18 kem, 210nm kuaj pom) | Pharmaceutical qib: Ntau dua lossis sib npaug rau 99.0% purity; Qib Nutraceutical: Ntau dua lossis sib npaug rau 98.0% purity |
| Optical Purity (Tsev Tshuaj) | Chiral HPLC (polysaccharide kem) | R-enantiomer Ntau dua lossis sib npaug rau 98.0% (natural form) |
| Yam khoom muaj feem | HPLC (gradient elution) | Ib qho impurity Tsawg dua lossis sib npaug li 0.2%; Tag nrho cov impurities Tsawg dua lossis sib npaug li 0.5% (qib tshuaj) |
| Hnyav Hlau | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pharmaceutical qib: Pb Tsawg dua lossis sib npaug li 5ppm; Qib Nutraceutical: Tsawg dua lossis sib npaug li 10ppm |
| Residual Solvents | GC (headspace sampling, FID ntes) | Chav kawm 2 cov kuab tshuaj tsawg dua lossis sib npaug ntawm 500ppm; Cov kuab tshuaj Class 1 tsis kuaj |
| Melting Point | Txoj kev Capillary tube | 60-62℃(tsis muaj decomposition) |
3. Kev ceeb toom kev nyab xeeb
Kev siv tib neeg (Qhov ncauj / IV):
Contraindications: Hypersensitivity rau Thioctic Acid los yog sulfur- muaj cov tshuaj; cev xeeb tub/lactation (tso cov ntaub ntawv kev nyab xeeb-siv nyob rau hauv kev saib xyuas kev kho mob).
Cov teebmeem tsis zoo: Rare and mild: nausea, diarrhea, skin rash (oral); injection site pain (IV). High doses (>1200 mg / hnub) tuaj yeem ua rau hypoglycemia hauv cov neeg mob ntshav qab zib (saib cov ntshav qabzib).
Kev siv tshuaj pleev ib ce:
Feem ntau muaj kev nyab xeeb rau kev siv tshuaj pleev ib ce; patch kuaj pom zoo rau cov tawv nqaij rhiab (tej zaum yuav ua rau mob me me hauv 1% -2% ntawm cov neeg siv).
Kev koom tes & kev sib cuag
Peb muab Thioctic Acid nyob rau hauv qib thiab cov ntaub ntawv raws li kev lag luam sib txawv:
Pharmaceutical Qib: Cov hmoov zoo (1kg–100kg ib qho kev txiav txim, amber iav vials lossis txhuas ntawv ci hnab) rau cov ntsiav tshuaj, tshuaj ntsiav, thiab IV formulations.
Nutraceutical Qib: Hmoov los yog microencapsulated granules (10kg–500kg ib qho kev txiav txim) rau kev noj zaub mov ntxiv (kev txhim kho kev ruaj ntseg hauv cov qauv).
Qib Tshuaj pleev ib ce: hmoov los yog roj-soluble solutions (5kg–200kg per order) rau cov khoom tu tawv nqaij.
Tus nqi - cov kev pabcuam ntxiv suav nrog:
Muab DMF (Drug Master File) rau cov kws tshuaj- cov khoom qib los txhawb EU/US/Asia rau npe.
Customized formulations (xws li, microencapsulation rau nutraceuticals, roj-soluble blends rau tshuaj pleev ib ce) los txhim kho stability thiab bioavailability.
Kev tswj hwm kev txhawb nqa rau nutraceuticals (ua raws li FDA GRAS, EU Novel Food rules) thiab tshuaj pleev ib ce (INCI labeling, Safety data sheets/SDS).
Yog tias koj yog cov chaw tsim tshuaj, nutraceutical hom, lossis cov tshuaj pleev ib ce, thov hu rau peb kom paub meej kev koom tes:
Cov ntaub ntawv tiv tauj:
Email: sales@huarongpharma.com
Xov tooj/WhatsApp: +86 13751168070
Peb ua raws li cov hauv paus ntsiab lus ntawm "ntau- qib zoo, kev siv ntau yam, thiab kev ua raws li kev nyab xeeb" thiab tos ntsoov rau kev koom tes nrog kev lag luam tshuaj, khoom noj khoom haus, thiab tshuaj pleev ib ce thoob ntiaj teb!
Cim npe nrov: Tuam Tshoj thioctic acid 62-46-4 manufacturers, lwm tus neeg
