Product Basic Information
| Yam khoom | Paub meej |
|---|---|
| Khoom npe | Metronidazole |
| CAS Nr. | 443-48-1 |
| Synonyms | 2-Methyl-5-nitroimidazole-1-ethanol; Flagyl® (hom npe rau tib neeg qhov ncauj / IV formulations) |
| Molecular Formula | C₆H₉N₃O₃ |
| Molecular Luj | 171.15 |
| Qhov tshwm sim | Dawb mus daj daj crystalline hmoov; Tsis muaj ntxhiab los yog nrog me ntsis cov yam ntxwv tsw |
| Specification | - Pharmaceutical Qib: Purity Ntau dua lossis sib npaug li 98.5% (HPLC); Melting point 159-163 degree; Poob ntawm ziab Tsawg dua lossis sib npaug li 0.5%; Residue ntawm ignition Tsawg dua los yog sib npaug rau 0.1%; Cov hlau hnyav (Pb Tsawg dua lossis sib npaug rau 10ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug rau 1ppm) -Veterinary Qib: Purity Ntau dua lossis sib npaug li 95.0% (HPLC); Ua raws li EP Vet / USP Vet; Tsis muaj nitroimidazole impurities (tsawg dua los yog sib npaug rau 0.1%) |
| Melting Point | 159-163 degree |
| Solubility | me ntsis soluble hauv dej (≈1 g / L ntawm 25 degree); Soluble hauv ethanol, methanol, thiab dilute acids / bases; Sparingly soluble hauv chloroform |
| Kev cia khoom | Khaws rau hauv qhov txias (15-25 degree), qhuav, lub teeb{2}}cov thawv tiv thaiv; Muab kaw kom tiv thaiv kom tsis txhob ya raws thiab photodegradation (nitro pawg yog lub teeb-rhiab heev); Lub neej txee: 36 lub hlis rau qib kws kho mob, 24 lub hlis rau qib kws kho tsiaj |
Core Functions & Applications
Metronidazole CAS#443-48-1 exerts nws cov tshuaj tua kab mob los ntawm kev nkag mus rau cov kab mob anaerobic lossis protozoa, qhov twg nws pawg nitro raug txo los ntawm microbial nitroreductase enzymes (active nkaus xwb nyob rau hauv ib puag ncig anaerobic). Daim ntawv txo qis ua rau cov microbial DNA (los ntawm kev tsim cov pa oxygen reactive thiab DNA cross-linking), ua rau kev tuag ntawm tes. Nws tsis muaj kev ua haujlwm tawm tsam aerobic lossis facultative anaerobic kab mob, ua rau nws tshwj xeeb rau cov kab mob anaerobic. Nws yog siv nyob rau hauv ob qho tib sitib neeg tshuajthiabkev xyaum ua tsiaj:
1. Human Pharmaceutical Field
1.1 Cov kab mob anaerobic kab mob
Intra- Kab mob plab: Ua ntej - kab mob rau peritonitis, abscesses (siab, plab), thiab mob plab hnyuv los ntawmBacteroides fragilis(qhov feem ntau cov kab mob anaerobic hauv plab). Siv raws li IV infusion (500 mg txhua 8 teev) lossis ntsiav tshuaj ntawm qhov ncauj (500 mg txhua 6 teev) rau 7-14 hnub, feem ntau ua ke nrog Gram-negative aerobic antibiotic (xws li ceftriaxone).
Daim tawv nqaij & cov ntaub so ntswg mos: Kho mob necrotizing fasciitis, mob ntshav qab zib ko taw ulcers, thiab qhov txhab mob nrog kev koom tes anaerobic (xws li,Clostridium perfringens, Peptostreptococcusspp.). Qhov ncauj / IV koob tshuaj: 500 mg txhua 6-8 teev rau 10-14 hnub, ua ke nrog kev phais mob yog tias xav tau.
Cov kab mob ua pa: Siv rau aspiration pneumonia thiab ntsws abscesses tshwm sim los ntawm anaerobic qhov ncauj flora (xws li,Prevotellaspp.). IV koob tshuaj: 500 mg txhua 8 teev rau 7-10 hnub, hloov mus rau qhov ncauj ib zaug kev kho mob tshwm sim.
1.2 Kab mob kab mob
Trichomoniasis: Tus qauv kub rau kev kho qhov chaw mos trichomoniasis (ua los ntawmTrichomonas vaginalis kab mob), a common sexually transmitted infection (STI). Single oral dose of 2 g (or 500 mg twice daily for 7 days) for both partners, with cure rates >95%.
Giardiasis: Kho plab hnyuv giardiasis (ua los ntawmGiardia lamblia)-ua rau tus neeg taug kev raws plab. Qhov ncauj koob tshuaj: 250 mg peb zaug ib hnub twg rau 5-7 hnub (cov neeg laus) lossis 15 mg / kg / hnub muab faib ua 3 koob tshuaj (cov menyuam yaus), daws qhov mob raws plab thiab mob plab.
Amebiasis: Siv tau rau plab hnyuv amebiasis (diarrhea los ntawmEntamoeba histolytica) thiab extraintestinal amebiasis (siab abscess). koob tshuaj ntawm qhov ncauj: 500-750 mg peb zaug ib hnub twg rau 5-10 hnub (plab hnyuv) los yog 7-14 hnub (siab abscess).
1.3 Lwm yam kab mob
Kev tshem tawm Helicobacter pylori: Ib feem ntawm triple/quadruple therapy forH. pylori(ua rau peptic ulcers, gastric cancer). Cov koob tshuaj ib txwm: 500 mg ob zaug ib hnub rau 7-14 hnub, ua ke nrog proton twj tso kua mis inhibitor (xws li, omeprazole) thiab penicillin (xws li amoxicillin).
2. Veterinary teb
2.1 Tus khub Tsiaj (Aub, Miv)
Cov kab mob anaerobic:
Canine pyoderma (kab mob ntawm daim tawv nqaij) thiab feline qhov ncauj abscesses tshwm sim los ntawmBacteroidesua spp. los yogClostridiumua spp. Cov ntsiav tshuaj ntawm qhov ncauj: 10-20 mg / kg lub cev hnyav ob zaug ib hnub rau 7-14 hnub.
Canine inflammatory plob tsis so tswj kab mob (IBD) nrog anaerobic overgrowth: Tsawg- noj qhov ncauj (5-10 mg / kg ib hnub ib zaug) rau 4-6 lub lis piam kom txo tau cov hnyuv.
Kab mob kab mob:
Canine giardiasis (ua rauGiardia duodenalis): koob tshuaj qhov ncauj (25 mg / kg lub cev hnyav ob zaug ib hnub rau 5 hnub) txhawm rau tshem tawm cov hlwv thiab kho raws plab.
Feline trichomoniasis (mob plab, tshwm sim los ntawmTritrichomonas fetus): koob tshuaj qhov ncauj (10-15 mg / kg ob zaug ib hnub twg rau 14 hnub), tab sis kuj yuav xav tau kev kho ua ke.
2.2 Tsiaj (Nqaij, Npua)
Cov kab mob anaerobic:
Bovine ko taw rot (ua rauFusobacterium necrophorum) thiab porcine necrotic enteritis (ua rauClostridium perfringens). Kev txhaj tshuaj (10 mg / kg lub cev hnyav ib zaug ib hnub rau 3-5 hnub) lossis qhov ncauj premixes (20-40 mg / kg pub) rau kev tiv thaiv pab pawg.
Kab mob kab mob:
Bovine trichomoniasis (qhov chaw mos, tshwm sim los ntawmTritrichomonas fetus-ua rau rho menyuam). Kev txhaj tshuaj (5 mg / kg lub cev hnyav ib zaug) rau bulls, txo cov kab mob.
Quality & Safety Assurance
Metronidazole qhov tshwj xeeb thiab kev siv dav dav yuav tsum muaj kev tswj hwm nruj kom ntseeg tau tias muaj txiaj ntsig, txo cov tshuaj toxicity, thiab tiv thaiv kev pheej hmoo seem hauv cov tsiaj txhu:
Raw Khoom & Synthesis: Ua los ntawm chemical synthesis (condensation ntawm 2-methylimidazole nrog ethylene oxide, ua raws li nitration) thiab purified los ntawm recrystallization. Cov ntaub ntawv nyoos raws li USP/EP cov qauv rau kev txwv tsis pub muaj kev txwv (piv txwv li, 2-methylimidazole Tsawg dua lossis sib npaug li 0.1%, cov khoom pib impurity).
Txheej txheem ntau lawm:
Pharmaceutical Qib: Ua nyob rau hauv GMP-cov chaw ua haujlwm tau ntawv pov thawj (Class D cleanroom rau kev ua tiav kawg) nrog cov khoom siv tiv thaiv kev tiv thaiv kom tsis txhob muaj teeb pom kev zoo -induced degradation ntawm nitro pawg.
Veterinary Qib: Tau txais kev kuaj ntxiv rau cov cim seem (xws li metronidazole metabolites Tsawg dua lossis sib npaug li 0.01 ppm hauv cov ntaub so ntswg noj tau) thiab ua raws li cov qauv kws kho tsiaj tsiaj.
Comprehensive Testing Protocol:
| Cov khoom kuaj | Txoj kev | Kev lees txais |
|---|---|---|
| Purity & Assay | HPLC (C18 kem, 277 nm nrhiav pom) | Pharmaceutical qib: Ntau dua lossis sib npaug rau 98.5% purity; Veterinary qib: Ntau dua lossis sib npaug rau 95.0% purity |
| Yam khoom muaj feem | HPLC (gradient elution) | Ib qho impurity Tsawg dua lossis sib npaug li 0.5%, tag nrho impurities Tsawg dua lossis sib npaug rau 1.0% |
| Hnyav Hlau | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pb Tsawg dua lossis sib npaug rau 10ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug rau 1ppm |
| Residue Solvents | GC (headspace sampling) | Ethanol Tsawg dua lossis sib npaug rau 5000ppm, Acetone Tsawg dua lossis sib npaug rau 500ppm |
| Sterility (Tshwj xeeb txhaj tshuaj) | Membrane filtration method | Tsis muaj kab mob / fungal loj hlob |
Kev ceeb toom kev nyab xeeb:Tib neeg siv:
Contraindications: hypersensitivity rau nitroimidazoles; thawj peb lub hlis twg ntawm cev xeeb tub (Qeb B hauv lub thib ob / peb lub hlis twg - zam yog tias ua tau); Kev siv dej cawv (disulfiram-zoo li cov tshuaj tiv thaiv: yaug, ntuav, hypotension).
Cov teebmeem tsis zoo: Kev tsis xis nyob hauv plab (xws li xeev siab, saj ntawm cov xim hlau), mob taub hau, thiab tsis tshua muaj neurotoxicity (peripheral neuropathy, qaug dab peg-tshem tawm yog tias cov tsos mob tshwm sim).
Kev siv Veterinary:
Lub Sijhawm Tshem Tawm: Nyuj: 28 hnub (nqaij), 96 teev (mis nyuj); Npua: 14 hnub (nqaij); Dogs/Cat: Tsis muaj lub sijhawm tshem tawm (tsis yog-cov tsiaj noj).
Contraindications: Tsis txhob noj cov tsiaj uas cev xeeb tub (tej zaum yuav ua rau muaj mob fetal) thiab cov tsiaj uas muaj lub siab tsis zoo (txo cov metabolism hauv tsub kom toxicity).
Kev koom tes & kev sib cuag
Peb muab Metronidazole CAS # 443-48-1 hauv ntau qib thiab cov qauv tsim kom tau raws li cov kev xav tau sib txawv:
Pharmaceutical Qib: Raw hmoov rau lub qhov ncauj ntsiav tshuaj, tshuaj ntsiav, IV txhaj, thiab tshuaj pleev gels (1kg-100kg ib qho kev txiav txim).
Veterinary Qib: Raw hmoov rau txhaj tshuaj, qhov ncauj tshem tawm, thiab premixes (10kg-500kg ib qho kev txiav txim; txhua hli muaj peev xwm ntawm 800kg).
Tus nqi - cov kev pabcuam ntxiv suav nrog:
Muab DMF (Drug Master File) thiab CEP (Certificate of Suitability) rau cov khoom siv tshuaj - qib los txhawb kev sau npe hauv EU, Asmeskas, thiab Asia.
Customized formulation kev txhawb nqa (xws li, saj daim npog qhov ncauj rau tus khub tsiaj lub qhov ncauj ncua kev kawm ntawv, solubility li qub rau IV kev daws teeb meem).
Kev taw qhia txog kev tswj hwm tus kab mob anaerobic (tib neeg / kws kho tsiaj cov neeg siv khoom) thiab kev zam cov khoom seem hauv cov tsiaj txhu.
Yog tias koj yog cov chaw tsim tshuaj, kws kho tsiaj ua lag luam, lossis tus khub tsiaj noj qab haus huv tuam txhab, thov hu rau peb kom paub meej kev koom tes:
Cov ntaub ntawv tiv tauj:
Email: sales@huarongpharma.com
Xov tooj/WhatsApp: +86 13751168070
Peb ua raws li cov hauv paus ntsiab lus ntawm "kev ua raws li kev ua tau zoo, qhov tseem ceeb ntawm kev nyab xeeb, thiab kev kho lub hom phiaj" thiab tos ntsoov rau kev koom tes nrog kev noj qab haus huv thoob ntiaj teb thiab cov tuam txhab kev noj qab haus huv tsiaj!
Cim npe nrov: Tuam Tshoj metronidazole cas#443-48-1 manufacturers, lwm tus neeg
