Kanamycin Acid Sulfate (CAS No.: 70560-51-9) - Aminoglycoside Antibacterial rau Gram-negative & Drug-Resistant Infections
Raws li tus kws tshaj lij ntawm cov kws kho mob - qib thiab kws kho tsiaj - qib tshuaj tua kab mob cov khoom xyaw, peb muab siab -purity Kanamycin Acid Sulfate uas ua raws li cov qauv tshuaj thoob ntiaj teb (USP, EP, BP, CP). Ib tug natural aminoglycoside tshuaj tua kab mob muab tau los ntawmStreptomyces kanamyceticus, nws nthuav tawm cov kab mob muaj zog tiv thaiv ntau yam ntawm Gram- cov kab mob tsis zoo thiab xaiv Gram- cov kab mob zoo. Nws yog dav siv nyob rau hauvtib neeg tshuajrau kev kho mob hnyav (xws li, tso zis, ua pa, thiab kab mob hauv lub cev) thiabkev xyaum ua tsiajrau cov tsiaj nyeg thiab cov tsiaj sib raug zoo- ua tus neeg sawv cev tseem ceeb tiv thaiv kab mob thiab tshuaj yeeb - cov kab mob resistant.
Product Basic Information
| Yam khoom | Paub meej |
|---|---|
| Khoom npe | Kanamycin Acid Sulfate |
| CAS Nr. | 70560-51-9 |
| Synonyms | O-3-Amino-3-deoxy- -D-glucopyranosyl-(1 →6)-O{{18} [6-amino-6-deoxy- -D-glucopyranosyl{13}}(1 → 6){17}}O{{18} [6-amino-6-deoxy- -D-glucopyranosyl] sulfate-(1 → Kanamycin sulfate (acid daim ntawv) |
| Molecular Formula | C₁₈H₃₆N₄O₁₁·nH₂SO₄ (feem ntau 1:1 acid sulfate ntsev, molecular hnyav ~ 582.5) |
| Molecular Luj | ~ 582.5 (rau 1: 1 acid sulfate ntsev, anhydrous) |
| Qhov tshwm sim | Dawb kom tawm -dawb crystalline hmoov los yog hygroscopic granules; Tsis hnov tsw |
| Specification | - Pharmaceutical Qib: Purity Ntau dua lossis sib npaug li 95.0% (HPLC); Assay (raws li kanamycin) 650-750 ug / mg (anhydrous hauv paus); Poob ntawm ziab Tsawg dua lossis sib npaug li 5.0%; Residue ntawm ignition 18.0% -22.0% (sulfate cov ntsiab lus); Cov hlau hnyav (Pb Tsawg dua lossis sib npaug ntawm 10ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug li 1ppm); Endotoxin Tsawg dua lossis sib npaug li 0.5 EU / mg (rau kev siv tshuaj txhaj)-Veterinary Qib: Purity Ntau dua lossis sib npaug li 90.0% (HPLC); Assay (as kanamycin) 600–700 ug/mg; Cov hlau hnyav tsawg dua lossis sib npaug li 20ppm |
| Melting Point | >250℃(nrog decomposition) |
| Solubility | Dawb soluble hauv dej (Ntau dua lossis sib npaug ntawm 300 g / L ntawm 25 degree); me ntsis soluble hauv methanol; Xyaum insoluble hauv ethanol, acetone, chloroform |
| Kev cia khoom | Khaws rau hauv qhov txias (15-25 degree), qhuav, lub teeb -cov thawv tiv thaiv; Sealed los tiv thaiv kev nqus dej (hygroscopic) thiab degradation; Tsis txhob sib cuag nrog cov acids muaj zog / bases; Lub neej txee: 36 lub hlis rau qib kws kho mob, 24 lub hlis rau qib kws kho tsiaj |
Core Functions & Mechanism of Action
CAS #70560-51-9 exerts abactericidal nyhuvlos ntawm kev tsom mus rau cov kab mob ribosome, cuam tshuam cov protein synthesis-ib yam ntxwv ntawm cov tshuaj tua kab mob aminoglycoside:
Ribosome Binding: Kanamycin khi irreversibly rau 30S subunit ntawm cov kab mob ribosome, tshwj xeeb interacting nrog 16S rRNA.
Protein Synthesis cuam tshuam: Qhov kev khi no thaiv ob kauj ruam tseem ceeb:
Kev pib ntawm kev sib txuas ntawm cov protein (tiv thaiv kev tsim ntawm ribosome-mRNA-tRNA complex).
Kev nyeem ntawv tseeb ntawm mRNA codons (ua rau misincorporation ntawm amino acids rau hauv cov proteins uas tau tsim tawm tshiab).
Kab mob tuag: Sib sau ua ke ntawm cov uas tsis yog - ua haujlwm, cov kuab tshuaj lom ua rau cov kab mob ntawm tes puas tsuaj, ua rau osmotic lysis thiab cell tuag.
Qhov tseem ceeb antibacterial spectrum zoo:
Gram{0}}Cov kev pab tsis zoo: Active tiv thaiv kab mob xws liEscherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacterspp ,uaSalmonellaspp.-xws li qee hom kab mob uas tiv taus penicillins lossis cephalosporins.
Gram{0}}Cov Kev Pab Zoo: Inhibits susceptibleStaphylococcus aureus(MSSA) thiabStreptococcusua spp. (tab sis tsis yog thawj - kab rau cov kab mob no).
Cov ntawv thov tseem ceeb
Kanamycin Acid Sulfate CAS#70560-51-9 yog siv rau parenterally (IV, IM) los yog topically (ophthalmic, otic) nyob rau hauv tib neeg (qhov ncauj absorption tsis zoo); nyob rau hauv kev siv veterinary, nws kuj yog siv nyob rau hauv lub qhov ncauj formulations rau gastrointestinal kab mob. Nws yog tshwj tseg raunruab nrab-rau- kab mob hnyavqhov twg lwm yam tshuaj tua kab mob tsis zoo los yog contraindicated.
1. Human Pharmaceutical Field
1.1 Cov kab mob hauv lub cev
Septicemia & Bacteremia: Kho cov kab mob hauv cov hlab ntsha uas tshwm sim los ntawm qhov raug Gram - cov kab mob tsis zoo (xws li,E. coli, K. pneumoniae). koob tshuaj IV/IM: 15–30 mg/kg/hnub ( muab faib ua 2–3 koob) rau 7–14 hnub, kho rau lub raum ua haujlwm.
Urinary Tract Infections (UTIs): Rau qhov nyuaj UTIs tiv taus thawj - kab tshuaj tua kab mob. koob tshuaj IV/IM: 15–30 mg/kg/hnub rau 7–10 hnub.
Respiratory Tract Infections (RTIs): Kho tsev kho mob- kis mob ntsws (HAP) tshwm sim los ntawm kev raug mobPseudomonas aeruginosalos yogAcinetobacterua spp. IV koob tshuaj: 15-30 mg / kg / hnub rau 10-14 hnub.
1.2 Cov kab mob kis
Cov kab mob Ophthalmic: Formulated raws li qhov muag tee / tshuaj pleev rau kab mob conjunctivitis los yog keratitis tshwm sim los ntawmStaphylococcus aureuslos yogHemophilus influenzae(0.5% concentration, 1-2 tee txhua 4 teev).
Cov kab mob Otic: Siv rau hauv pob ntseg tee rau cov kab mob otitis externa (ua ke nrog hydrocortisone kom txo qhov mob, 0.3% concentration, 3-4 tee txhua hnub).
1.3 Lwm yam kev siv
Txoj hnyuv Sterilization: Oral formulations (tsis absorbed systemically) rau ua ntej - phais plab hnyuv kom txo tau Gram-negative flora (1-2 g / hnub rau 2-3 hnub).
Tuberculosis (TB): Thib ob -tus neeg sawv cev rau cov tshuaj- tiv thaiv kab mob TB (ua ke nrog lwm cov tshuaj tiv thaiv-TB, 15 mg/kg/hnub rau 6–12 lub hlis).
2. Veterinary Field (Tshuaj Tsiaj & Tsiaj Tsiaj Tsiaj)
CAS # 70560-51-9 yog siv los kho cov kab mob hauv cov kab mobnyuj, npua, qaib, dev, thiab miv:
Bovine Respiratory Disease (BRD): Ua los ntawm susceptibleMannheimia hemolyticalos yogPasteurella multocida. koob tshuaj IM: 10-15 mg / kg lub cev hnyav ib hnub ib zaug rau 3-5 hnub.
Porcine Diarrhea: RauE. coli-induced scours nyob rau hauv piglets. Qhov ncauj / IM koob tshuaj: 10-20 mg / kg ib hnub ib zaug rau 3-5 hnub.
Nqaij qaib Colibacillosis: KhoE. colikab mob hauv qaib. Qhov ncauj koob tshuaj: 20-40 mg / kg pub los yog haus dej rau 5-7 hnub.
Canine/Feline UTIs & Kab mob ntawm daim tawv nqaij: Rau susceptibleE. coli(UTIs) lubStaphylococcus pseudintermediaus(daim tawv nqaij). koob tshuaj IM: 5-10 mg / kg ob zaug ib hnub rau 7-14 hnub.
Contraindications: Tsis txhob siv rau hauv cov menyuam yaus (kev pheej hmoo nephrotoxicity) lossis cov tsiaj uas muaj ua ntej - lub raum tsis zoo; tsis pom zoo rau cov nyuj uas muaj mis nyuj ua mis nyuj rau tib neeg noj.
Quality & Safety Assurance
Raws li ib qho aminoglycoside nrog qhov ntsuas nqaim (kev pheej hmoo ntawm nephrotoxicity thiab ototoxicity), yuav tsum muaj kev tswj xyuas zoo kom ntseeg tau tias muaj zog, purity, thiab kev nyab xeeb:
1. Kev tsim khoom & Purity Control
Ntau lawm: Ua los ntawm microbial fermentation ntawmStreptomyces kanamyceticus, ua raws li kev ua kom huv (ion- pauv chromatography) thiab acid sulfate ntsev tsim. Cov txheej txheem kom ntseeg tau tias:
Tsawg impurities (piv txwv li, muaj feem xyuam nrog aminoglycosides, fermentation byproducts) Tsawg dua los yog sib npaug li 2.0% (qib kws tshuaj);
Cov ntsiab lus sulfate zoo ib yam (18.0% - 22.0%), tseem ceeb rau kev muaj zog sib xws.
Ua raws li GMP: Pharmaceutical-qib Kanamycin Acid Sulfate CAS#70560-51-9 yog tsim nyob rau hauv Qib C/D cleanrooms (raws li ICH Q7 cov lus qhia) rau kev txhaj tshuaj, nrog rau kev tswj nruj ntawm cov tshuaj endotoxin (tsawg dua los yog sib npaug rau 0.5 EU/mg) kom tsis txhob muaj kab mob sepsis.
2. Cov Txheej Txheem Kev Ntsuas Zoo
| Cov khoom kuaj | Txoj kev | Kev lees txais |
|---|---|---|
| Purity & Assay | HPLC (C18 kem, 205nm kuaj pom) | Pharmaceutical qib: Ntau dua lossis sib npaug rau 95.0% purity; Assay 650–750 ug/mg |
| Yam khoom muaj feem | HPLC (gradient elution) | Ib qho impurity Tsawg dua lossis sib npaug li 1.0%; Tag nrho cov impurities Tsawg dua lossis sib npaug li 2.0% (qib tshuaj) |
| Endotoxin (Kev txhaj tshuaj qib) | LAL (limulus Amebocyte Lysate) Test | Tsawg dua lossis sib npaug li 0.5 EU / mg |
| Hnyav Hlau | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pharmaceutical qib: Pb Tsawg dua lossis sib npaug ntawm 10ppm; Veterinary qib: Tsawg dua lossis sib npaug li 20ppm |
| Solubility & Clarity | Gravimetric txoj kev (dej, 25 degree) | Ntau tshaj lossis sib npaug rau 300 g / L solubility; Clear daws (tsis muaj turbidity) |
| Poob rau ziab | Gravimetric method (105℃rau 3 teev) | Tsawg dua lossis sib npaug li 5.0% (qib tshuaj) |
3. Kev ceeb toom kev nyab xeeb
Tib neeg siv:
Contraindications: hypersensitivity rau aminoglycosides; mob raum tsis zoo (CrCl<30 mL/min); pre-existing hearing loss or tinnitus (ototoxicity risk); myasthenia gravis (neuromuscular blockade risk).
Cov teebmeem tsis zoo: Dose-dependent nephrotoxicity (saib ntshav creatinine, BUN) thiab ototoxicity (saib lub rooj sib hais / vestibular muaj nuj nqi); Tsis tshua muaj tab sis hnyav: neuromuscular paralysis (kho nrog calcium gluconate).
Therapeutic Drug Monitoring (TDM): Yuav tsum tau rau cov neeg mob lub raum tsis zoo los yog kev kho mob ntev -lub hom phiaj ncov siab 20–30 ug/mL, trough concentration<10 μg/mL.
Kev siv Veterinary:
Lub Sijhawm rho nyiaj: Nyuj: 28 hnub (nqaij); Npua: 21 hnub (nqaij); Nqaij qaib: 7 hnub (nqaij / qe); Dogs/Cat: Tsis muaj lub sijhawm tshem tawm (tsis yog-cov tsiaj noj).
Residue ceeb toom: Txwv tsis pub noj cov nyuj (cov kua mis seem) thiab nteg qe (qe residues) dhau lub sijhawm tshem tawm.
Kev koom tes & kev sib cuag
Peb muab Kanamycin Acid Sulfate CAS # 70560-51-9 nyob rau hauv qib tailored rau tib neeg thiab veterinary daim ntaub ntawv:
Pharmaceutical Qib: Cov hmoov zoo rau kev txhaj tshuaj / tshuaj pleev ib ce (1kg-100kg rau ib qho kev txiav txim, ntim cov hnab ntim aluminium ntawv nrog cov desiccants).
Veterinary Qib: Hmoov rau tsiaj txhu qhov ncauj premixes lossis txhaj tshuaj (10kg-500kg ib qho kev txiav txim; txhua hli muaj peev xwm ntawm 2000kg).
Tus nqi - cov kev pabcuam ntxiv suav nrog:
Muab DMF (Drug Master File) thiab CEP (Certificate of Suitability) rau cov kws tshuaj -qib cov khoom los txhawb EU/US/Asia rau npe.
Kev them nyiaj yug rau TDM raws tu qauv (tib neeg siv) thiab kev ntsuam xyuas kev ruaj ntseg ntawm kws kho tsiaj (xws li, qhov ncauj premixes, injectables).
Batch- tshwj xeeb COA nrog endotoxin, purity, thiab kev soj ntsuam cov txiaj ntsig kom ua raws li kev tswj hwm.
Yog tias koj yog cov chaw tsim tshuaj, tus neeg muag khoom hauv tsev kho mob, lossis kev lag luam tshuaj veterinary, thov hu rau peb kom paub meej kev koom tes:
Cov ntaub ntawv tiv tauj:
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Peb ua raws li cov hauv paus ntsiab lus ntawm "kev tiv thaiv kab mob, kev nyab xeeb ua raws, thiab kev tswj hwm kev tiv thaiv" thiab tos ntsoov rau kev koom tes nrog kev lag luam thoob ntiaj teb kev noj qab haus huv thiab tsiaj noj qab haus huv kev lag luam!
Cim npe nrov: Tuam Tshoj kanamycin acid sulfate cas#70560-51-9 manufacturers, lwm tus neeg
