Erythromycin (CAS No.: 114-07-}8) - Macrolide Antibacterial rau Gram-Positive & Atypical Infections
Raws li tus kws tshaj lij ntawm cov kws kho mob - qib thiab kws kho tsiaj - qib tshuaj tua kab mob cov khoom xyaw, peb muab siab -purity Erythromycin uas nruj me ntsis ua raws li cov qauv tshuaj tshuaj thoob ntiaj teb (USP, EP, BP, CP). Ib tug natural macrolide tshuaj tua kab mob muab tau los ntawmStreptomyces erythreus, nws nthuav tawm cov kab mob bacteriostatic uas muaj zog (thiab cov kab mob bactericidal ntawm cov koob tshuaj siab) ua haujlwm tawm tsam Gram- cov kab mob zoo thiab cov kab mob atypical. Nws yog dav siv nyob rau hauvtib neeg tshuajrau kev kho cov kab mob ua pa, tawv nqaij, thiab cov nqaij mos-tshwj xeeb tshaj yog nyob rau hauv cov neeg mob ua xua rau penicillins- thiab hauvkev xyaum ua tsiajrau cov tsiaj nyeg thiab cov tsiaj sib raug zoo, ua haujlwm ua tus neeg sawv cev hauv kev kho cov kab mob tua kab mob.
Product Basic Information
| Yam khoom | Paub meej |
|---|---|
| Khoom npe | Erythromycin |
| CAS Nr. | 114-07-8 (Ceeb Toom: Kho CAS rau Erythromycin; qhov "114-07-08" muab yog typo) |
| Synonyms | 3R,4S,5S,6R,7R,9R,10R,11R,12S,13R)-6,11,12,13-Tetrahydroxy-3,7,9,11,13-pentamethyl-10-[(E)-1-oxo-3-(3) 4,5-trihydroxyphenyl)prop-2-en-1-yl]-2,4,6,8,10,12-hexahydro-1H-3,5,7-trioxacyclopentadecine-1,9-dione |
| Molecular Formula | C₃₇H₆₇NO₁₃ |
| Molecular Luj | 733.93 |
| Qhov tshwm sim | Dawb kom tawm -dawb crystalline hmoov los yog hygroscopic granules; Tsis muaj ntxhiab los yog nrog me ntsis cov yam ntxwv tsw |
| Specification | - Pharmaceutical Qib: Purity Ntau dua lossis sib npaug li 98.0% (HPLC); Assay 950-1050 ug / mg (anhydrous hauv paus); Poob ntawm ziab Tsawg dua lossis sib npaug li 2.0%; Cov hlau hnyav (Pb Tsawg dua lossis sib npaug ntawm 5ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug li 1ppm); Cov kuab tshuaj seem (ethanol Tsawg dua lossis sib npaug rau 500ppm, acetone Tsawg dua lossis sib npaug rau 500ppm)-Veterinary Qib: Purity Ntau dua lossis sib npaug li 95.0% (HPLC); Assay 900–1100 ug/mg; Cov hlau hnyav tsawg dua lossis sib npaug li 10ppm |
| Melting Point | 135-140℃(nrog decomposition) |
| Solubility | Xyaum insoluble hauv dej (≈0.1 g / L ntawm 25 degree); Soluble hauv ethanol (≈50 g / L), methanol (≈80 g / L), chloroform (≈200 g / L), thiab acetone; Me ntsis soluble hauv ether |
| Kev cia khoom | Khaws rau hauv qhov txias (15-25 degree), qhuav, lub teeb -cov thawv tiv thaiv; Sealed los tiv thaiv kev nqus dej (hygroscopic) thiab degradation (rhiab rau acid / alkali); Tsis txhob sib cuag nrog cov oxidizing muaj zog; Lub neej txee: 36 lub hlis rau qib kws kho mob, 24 lub hlis rau qib kws kho tsiaj |
Core Functions & Mechanism of Action
Erythromycin siv nwsantibacterial nyhuvlos ntawm kev tsom cov kab mob ribosome, inhibiting protein synthesis- tseem ceeb rau cov kab mob loj hlob thiab ciaj sia:
Ribosome Binding: yog khi reversibly rau 50S subunit ntawm cov kab mob ribosome, tshwj xeeb cuam tshuam nrog 23S rRNA thiab ribosomal proteins L4 thiab L22.
Protein Synthesis Blockade: Qhov kev khi no tiv thaiv cov kauj ruam hloov pauv ntawm cov protein synthesis- thaiv kev txav ntawm ribosome raws mRNA thiab txwv tsis pub ntxiv cov amino acids tshiab rau cov saw peptide loj hlob.
Bacteriostatic/Bactericidal Activity: Ntawm koob tshuaj, nws suppresses cov kab mob loj hlob (bacteriostatic); ntawm koob tshuaj ntau los yog tawm tsam cov kab mob uas raug mob (xws li,Streptococcus pneumoniae), nws tuaj yeem tua cov kab mob (bactericidal) los ntawm kev cuam tshuam cov membrane kev ncaj ncees.
Qhov tseem ceeb antibacterial spectrum zoo:
Gram{0}}Cov Kev Pab Zoo: Active tiv thaivStaphylococcus aureus(MSSA),Streptococcus pyogenes muaj(Pab pawg A strep),Streptococcus pneumoniae, thiabCorynebacterium diphtheriae-zoo tagnrho rau penicillin- cov neeg mob ua xua.
Atypical Pathogen Kev Pabcuam: Siv tau tawm tsamMycoplasma pneumoniae, Chlamydophila pneumoniae, Chlamydia trachomatis, thiabLegionella pneumophila- tseem ceeb heev rau kev kis kab mob ua pa thiab kev sib deev (STIs).
Gram{0}}Cov kev pab tsis zoo: Inhibits xaiv Gram- cov kab mob tsis zoo xws liHemophilus influenzaethiabNeisseria gonorrhoeae: kev kho mob(tab sis tsis yog thawj - kab rau cov kab mob no).
Cov ntawv thov tseem ceeb
Erythromycin CAS#114-07-08 yog muab tshuaj rau qhov ncauj (tab sis, tshuaj ntsiav, tshuaj ncua) lossis tshuaj pleev (tshuaj pleev, tshuaj pleev qhov muag); Parenteral formulations (IV) kuj muaj rau cov kab mob hnyav. Nws tsis muaj zog tiv thaiv kab mob (xws li, mob khaub thuas/flu) lossis Gram-negative rods (xws li,E. coli, Klebsiella).
1. Human Pharmaceutical Field
1.1 Kab mob ua pa
Zej Zog -Tau mob ntsws (CAP): Kho CAP tshwm sim los ntawmMycoplasma pneumoniae, Chlamydophila pneumoniae, los yog penicillin -sensitiveS. pneumoniae(penicillin{0}}cov neeg mob tsis haum). koob tshuaj qhov ncauj: 500 mg txhua 6 teev lossis 1 g txhua 12 teev rau 7-14 hnub; koob tshuaj IV: 500 mg–1 g txhua 6 teev rau cov mob hnyav.
Mob pharyngitis / tonsillitis: RauStreptococcus pyogenes muajkab mob (penicillin-cov neeg mob tsis haum). koob tshuaj qhov ncauj: 250 mg txhua 6 teev rau 10 hnub (tiv thaiv rheumatic fever).
Legionnaires Tus Kab Mob: Thawj - kab kev kho rauLegionella pneumophilakab mob. IV / qhov ncauj koob tshuaj: 1-2 g txhua hnub (raug faib ua 4 koob) rau 10-14 hnub.
1.2 Daim tawv nqaij & Cov ntaub so ntswg mos
Impetigo & Cellulitis: KhoStaphylococcus aureuslos yogStreptococcus pyogenes muajkab mob. koob tshuaj qhov ncauj: 250-500 mg txhua 6 teev rau 7-10 hnub; Tshuaj pleev ib ce (2%) siv 3-4 zaug ib hnub twg rau cov mob me.
Kab mob hawb pob: Adjuvant therapy rau diphtheria antitoxin, tshem tawmCorynebacterium diphtheriaelos ntawm caj pas. Qhov ncauj koob tshuaj: 250-500 mg txhua 6 teev rau 14 hnub.
1.3 Kev sib deev kis kab mob (STIs)
Kab mob Chlamydia Trachomatis: Kho urethritis, cervicitis, lossis pelvic inflammatory disease (PID) hauv cov neeg mob ua xua rau azithromycin. Qhov ncauj koob tshuaj: 500 mg ob zaug ib hnub rau 7 hnub.
Gonorrhea: Alternative therapy forNeisseria gonorrhoeae: kev kho mob(thaum thawj - tus neeg sawv cev kab tsis muaj). Qhov ncauj koob tshuaj: 500 mg txhua 6 teev rau 7 hnub (sib txuas nrog probenecid rau kev ua kom muaj txiaj ntsig zoo).
1.4 Kev kis kab mob
Cov kab mob Ophthalmic: Tshuaj pleev qhov muag (0.5%) rau cov kab mob conjunctivitis (xws li,Hemophilus influenzae, Staphylococcus aureus)- siv 1-2 zaug hauv ib hnub rau 7-10 hnub.
Pob txuv Vulgaris: Tshuaj pleev gel/ointment (2%) rau me me-rau- pob txuv nruab nrab, txoCov kab mob ntawm daim tawv nqaijcolonization-ib zaug ib hnub.
2. Veterinary Field (Tshuaj Tsiaj & Tsiaj Tsiaj Tsiaj)
CAS # 114-07-08 yog siv los kho cov kab mob hauv cov kab mobnyuj, npua, qaib, dev, thiab miv:
Bovine Respiratory Disease (BRD): Ua los ntawmMannheimia hemolyticalos yogMycoplasma kab mob. IM / koob tshuaj hauv qhov ncauj: 10-20 mg / kg lub cev hnyav ib hnub ib zaug rau 3-5 hnub.
Porcine Respiratory Disease Complex (PRDC): RauMycoplasma hyopneumoniaelos yogStreptococcus uakab mob. Qhov ncauj koob tshuaj: 20-40 mg / kg pub rau 7-10 hnub.
Poultry Chronic Respiratory Disease (CRD): KhoMycoplasma gallisepticumkab mob hauv qaib. Qhov ncauj koob tshuaj: 10-20 mg / kg haus dej rau 5-7 hnub.
Canine/Feline daim tawv nqaij & pob ntseg kab mob: RauStaphylococcus pseudintermediaus(dawb) los yogMycoplasmaua spp. (pob ntseg). koob tshuaj ntawm qhov ncauj: 10-20 mg / kg ob zaug ib hnub rau 7-14 hnub; Cov tshuaj pleev pob ntseg (0.5%) siv ob zaug ib hnub.
Contraindications: Zam tsis txhob siv nees (colitis txaus ntshai) lossis tsiaj uas muaj ua ntej- muaj kev puas siab puas ntsws; tsis pom zoo rau cov nyuj uas muaj mis nyuj ua mis nyuj rau tib neeg noj.
Quality & Safety Assurance
Raws li cov tshuaj tua kab mob macrolide tau siv dav, Erythromycin CAS#114-07-08 yuav tsum muaj kev tswj xyuas nruj kom ntseeg tau tias muaj zog, purity, thiab kev nyab xeeb-tshwj xeeb tshaj yog muab nws lub peev xwm rau kev mob plab hnyuv thiab kev siv tshuaj yeeb:
1. Kev tsim khoom & Purity Control
Ntau lawm: Ua los ntawm microbial fermentation ntawmStreptomyces erythreus, ua raws li kev ua kom huv (cov kuab tshuaj extraction, chromatography) thiab crystallization. Cov txheej txheem kom ntseeg tau tias:
Yam tsawg kawg nkaus impurities (piv txwv li, degradation khoom, ntsig txog macrolides) Tsawg dua los yog sib npaug rau 1.0% (qib tshuaj);
Kev muaj peev xwm sib xws (950-1050 ug / mg) rau cov txiaj ntsig kho tau zoo.
Ua raws li GMP: Pharmaceutical-qib Erythromycin CAS#114-07-08 yog tsim nyob rau hauv Qib D cleanrooms (raws li ICH Q7 cov lus qhia); Veterinary qib ua raws li GMP rau tsiaj tshuaj.
2. Cov Txheej Txheem Kev Ntsuas Zoo
| Cov khoom kuaj | Txoj kev | Kev lees txais |
|---|---|---|
| Purity & Assay | HPLC (C18 kem, 210nm kuaj pom) | Pharmaceutical qib: Ntau dua lossis sib npaug rau 98.0% purity; Assay 950–1050 ug/mg |
| Yam khoom muaj feem | HPLC (gradient elution) | Ib qho impurity Tsawg dua lossis sib npaug li 0.5%; Tag nrho cov impurities Tsawg dua lossis sib npaug rau 1.0% (qib tshuaj) |
| Hnyav Hlau | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pharmaceutical qib: Pb Tsawg dua lossis sib npaug li 5ppm; Veterinary qib: Tsawg dua lossis sib npaug li 10ppm |
| Residual Solvents | GC (headspace sampling, FID ntes) | Chav kawm 2 cov kuab tshuaj tsawg dua lossis sib npaug ntawm 500ppm; Cov kuab tshuaj Class 1 tsis kuaj |
| Poob rau ziab | Gravimetric method (105℃rau 2 teev) | Tsawg dua lossis sib npaug li 2.0% (qib tshuaj) |
| Kev txheeb xyuas | IR Spectroscopy & HPLC Retention Time | Sib tw siv tus qauv spectrum; Lub sijhawm khaws cia raws li tus qauv |
3. Kev ceeb toom kev nyab xeeb
Tib neeg siv:
Contraindications: Hypersensitivity rau macrolides tshuaj tua kab mob; keeb kwm ntawm QT ncua ncua sij hawm (tsis txhob siv tshuaj tiv thaiv arrhythmic zoo li amiodarone); mob siab heev.
Cov teebmeem tsis zoo: Feem ntau: plab hnyuv (xws li, raws plab, mob plab) (mob nrog enteric-coated formulations); Tsis tshua muaj tab sis hnyav: cholestatic jaundice (rov qab tau thaum tsis txuas ntxiv), ototoxicity (siab koob tshuaj).
Cov tshuaj sib cuam tshuam: Inhibits CYP3A4 enzymes- zam kev siv nrog warfarin (kev pheej hmoo los ntshav ntau), simvastatin (rhabdomyolysis txaus ntshai), lossis cyclosporine (muaj kev pheej hmoo siab nephrotoxicity).
Kev siv Veterinary:
Lub Sijhawm rho nyiaj: Nyuj: 21 hnub (nqaij); Npua: 14 hnub (nqaij); Nqaij qaib: 7 hnub (nqaij / qe); Dogs/Cat: Tsis muaj lub sijhawm tshem tawm (tsis yog-cov tsiaj noj).
Residue ceeb toom: Txwv tsis pub noj cov nyuj (cov kua mis seem) thiab nteg qe (qe residues) dhau lub sijhawm tshem tawm.
Kev koom tes & kev sib cuag
Peb muab Erythromycin hauv qib thiab cov ntaub ntawv raws li kev siv tib neeg thiab tsiaj txhu:
Pharmaceutical Qib: Cov hmoov zoo los yog enteric-coated granules (1kg-100kg ib qho kev txiav txim, kaw lub hnab aluminium foil nrog desiccants) rau qhov ncauj / tshuaj pleev ib ce.
Veterinary Qib: Hmoov rau tsiaj txhu qhov ncauj premixes lossis txhaj tshuaj (10kg-500kg ib qho kev txiav txim; txhua hli muaj peev xwm ntawm 2500kg).
Tus nqi - cov kev pabcuam ntxiv suav nrog:
Muab DMF (Drug Master File) thiab CEP (Certificate of Suitability) rau cov kws tshuaj -qib cov khoom los txhawb EU/US/Asia rau npe.
Kev txhawb nqa rau cov txheej txheej enteric (txo cov kev mob plab hnyuv) thiab kev kuaj xyuas kev ruaj ntseg ntawm kws kho tsiaj.
Batch-COA tshwj xeeb nrog kev ua kom huv, kev soj ntsuam, thiab cov kuab tshuaj uas seem tshuav los xyuas kom muaj kev ua raws cai.
Yog tias koj yog cov chaw tsim tshuaj, nutraceutical hom, lossis kev lag luam tshuaj veterinary, thov hu rau peb kom paub meej kev koom tes:
Cov ntaub ntawv tiv tauj:
Email: sales@huarongpharma.com
Xov tooj/WhatsApp: +86 13751168070
Peb ua raws li cov hauv paus ntsiab lus ntawm "kev siv tshuaj tua kab mob, kev ua raws li kev nyab xeeb, thiab ntau yam" thiab tos ntsoov rau kev koom tes nrog kev lag luam thoob ntiaj teb kev noj qab haus huv thiab tsiaj txhu kev lag luam!
Cim npe nrov: Tuam Tshoj erythromycin cas#114-07-08 manufacturers, lwm tus neeg
