Doxycycline Hyclate (CAS No.: 24390-14-}5) - Broad-Spectrum Tetracycline Antibacterial rau Tib Neeg & Veterinary Siv
Raws li tus kws tshaj lij ntawm cov kws kho mob - qib thiab kws kho tsiaj - qib tshuaj tua kab mob cov khoom xyaw, peb muab siab -purity Doxycycline Hyclate uas nruj me ntsis raws li cov qauv tshuaj thoob ntiaj teb (USP, EP, BP, CP Vet). Thib ob - tiam tetracycline derivative, nws nthuav tawm qhov muaj zog, txhim kho qhov nqus ntawm qhov ncauj, thiab ntev dua ib nrab- lub neej piv rau cov laus tetracyclines (xws li tetracycline, oxytetracycline). Nws yog dav siv nyob rau hauvtib neeg tshuajkho cov kab mob thiab cov kab mob protozoal, thiab hauvkev xyaum ua tsiajrau kev tswj cov kab mob sib kis hauv cov tsiaj nyeg thiab cov tsiaj ua ke - ua kom nws muaj ntau yam thiab kho cov kab mob tseem ceeb heev.
Product Basic Information
| Yam khoom | Paub meej |
|---|---|
| Khoom npe | Doxycycline Hyclate (Doxycycline Hydrochloride Hemihydrate Ethanolate) |
| CAS Nr. | 24390-14-5 |
| Synonyms | (4S, 4aS, 5aR, 6S, 12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1-caride-chlorideamideamide hemihydrate ethanolate; Vibramycin® (hom npe rau tib neeg siv) |
| Molecular Formula | C₂₂H₂₄N₂O₈·HCl·0.5H₂O·0.5C₂H₅OH |
| Molecular Luj | 512.94 |
| Qhov tshwm sim | Yellow crystalline hmoov; Tsis muaj ntxhiab los yog nrog me ntsis cov yam ntxwv tsw |
| Specification | - Pharmaceutical Qib: Purity Ntau dua lossis sib npaug li 98.0% (HPLC); Assay (raws li doxycycline) Ntau dua lossis sib npaug rau 89.0% (anhydrous hauv paus); Poob ntawm ziab Tsawg dua lossis sib npaug li 8.0%; Residue ntawm ignition Tsawg dua los yog sib npaug li 0.5%; Cov hlau hnyav (Pb Tsawg dua lossis sib npaug rau 10ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug rau 1ppm)-Veterinary Qib: Purity Ntau dua lossis sib npaug li 95.0% (HPLC); Ua raws li EP Vet / USP Vet; Tsis muaj tetracycline analogs (tsawg dua lossis sib npaug li 0.1%) |
| Melting Point | 206-210℃(nrog decomposition) |
| Solubility | Dawb soluble hauv dej (Ntau dua lossis sib npaug ntawm 50 g / L ntawm 25 degree); Soluble hauv methanol, ethanol; me ntsis soluble hauv acetone; Insoluble hauv chloroform, ether |
| Kev cia khoom | Khaws rau hauv qhov txias (15-25 degree), qhuav, tiv thaiv lub teeb; Sealed los tiv thaiv kev nqus noo noo thiab photodegradation; Lub neej txee: 36 lub hlis rau qib kws kho mob, 24 lub hlis rau qib kws kho tsiaj |
Core Functions & Applications
Doxycycline Hyclate exerts nws cov kab mob bacteriostatic los ntawm kev khi rau 30S subunit ntawm cov kab mob ribosomes, inhibiting kev khi ntawm aminoacyl-tRNA rau mRNA-ribosome complex- yog li thaiv cov kab mob protein synthesis. Nws muaj qhov dav dav ntawm kev ua haujlwm tawm tsam Gram- cov kab mob zoo, Gram- cov kab mob tsis zoo, thiab qee yam protozoa (xws li,Plasmodium, Chlamydia). Nws cov txiaj ntsig tseem ceeb suav nrogzoo heev ntawm qhov ncauj bioavailability(90-100%, tsis cuam tshuam los ntawm zaub mov),ntev ib nrab -lub neej(12-22 teev, tso cai noj ib hnub ib zaug), thiabnkag mus rau hauv cov ntaub so ntswg(piv txwv li, ntsws, tawv nqaij, prostate). Nws yog siv nyob rau hauv ob qho tib sitib neeg tshuajthiabkev xyaum ua tsiaj:
1. Human Pharmaceutical Field
1.1 Kab mob ua pa
Zej Zog -Tau mob ntsws (CAP): Thawj- kab kev kho mob rau CAP tshwm sim los ntawmStreptococcus pneumoniae(penicillin-sensitive),Mycoplasma pneumoniae, los yogChlamydophila pneumoniae. Qhov ncauj koob tshuaj: 100 mg ob zaug ib hnub (los yog 200 mg ib hnub ib zaug) rau 7-14 hnub.
Chronic Bronchitis Exacerbation: Kho cov kab mob exacerbations tshwm sim los ntawmHemophilus influenzaelos yogMoraxella catarrhalis. koob tshuaj: 100 mg ob zaug ib hnub rau 5-7 hnub, txo cov tsos mob thiab tiv thaiv teeb meem.
1.2 Daim tawv nqaij & Cov ntaub so ntswg mos
Pob txuv Vulgaris: Siv rau nruab nrab-rau- pob txuv mob hnyav (papules, pustules) tshwm sim los ntawmCov kab mob ntawm daim tawv nqaij. Qhov ncauj koob tshuaj: 50-100 mg ib hnub twg rau 6-12 lub lis piam, los yog tshuaj pleev ib ce (2% gel) rau cov mob me me-txo cov kab mob thiab cov kab mob.
Cellulitis & Lyme Kab Mob: Kho cellulitis tshwm sim los ntawmStaphylococcus aureus(methicillin-sensitive) thiab kab mob Lyme thaum ntxov (ua los ntawmBorrelia burgdorferi: koj puas xav tau ntau tus thwjtim?). koob tshuaj: 100 mg ob zaug ib hnub twg rau 14-21 hnub (Lyme kab mob) los yog 7-10 hnub (cellulitis).
1.3 Lwm yam kab mob
Kev sib deev kis kab mob (STIs): Thawj - kab kev kho rauChlamydia trachomatis(urethritis/cervicitis) thiab lwm txoj rauNeisseria gonorrhoeae: kev kho mob. koob tshuaj: 100 mg ob zaug ib hnub twg rau 7 hnub (chlamydia) lossis 200 mg ib hnub ib zaug rau 7 hnub (gonorrhea).
Malaria Prophylaxis: Siv rau cov neeg taug kev mus rau malaria- thaj chaw ib puag ncig (xws li Africa, Southeast Asia). koob tshuaj: 100 mg ib hnub twg, pib 1-2 hnub ua ntej mus ncig thiab txuas ntxiv 4 lub lis piam tom qab rov qab-zoo tiv thaivPlasmodium falciparum.
2. Veterinary teb
2.1 Tsiaj txhu (Nyob, Npua, Yaj)
Cov kab mob ua pa:
Bovine respiratory disease (BRD) nyob rau hauv cov nyuj feedlot (ua los ntawmMannheimia hemolytica, Pasteurella multocida): Kev txhaj tshuaj (20 mg / kg lub cev hnyav, intramuscularly ib zaug txhua 48 teev rau 2 koob) lossis qhov ncauj premixes (100-200 mg / kg pub) rau kev tiv thaiv pab pawg.
Porcine respiratory disease complex (PRDC) hauv npua (ua los ntawmActinobacillus pleuropneumoniae yog cov kab mob, Mycoplasma hyopneumoniae): Cov hmoov soluble hauv qhov ncauj (10-20 mg / kg lub cev qhov hnyav txhua hnub) rau 5-7 hnub, txo kev tuag thiab txhim kho kev hloov pauv khoom noj.
Kab mob plab:
Porcine proliferative enteropathy (PPE) hauv npua loj hlob (ua rauLawsonia intracellularis): koob tshuaj qhov ncauj (15 mg / kg lub cev qhov hnyav txhua hnub) rau 7 hnub, txo qhov mob raws plab thiab plab hnyuv.
2.2 Tus khub Tsiaj (Aub, Miv)
Kab mob kab mob:
Cov kab mob ntawm daim tawv nqaij (pyoderma) hauv dev (ua los ntawmStaphylococcus pseudintermediaus): Cov ntsiav tshuaj ntawm qhov ncauj (5-10 mg / kg lub cev hnyav ib hnub) rau 14-21 hnub, ua ke nrog tshuaj tua kab mob.
Urinary tract infections (UTIs) hauv miv (ua los ntawmEscherichia coli, Enterococcusspp.): koob tshuaj qhov ncauj (5 mg / kg lub cev qhov hnyav ob zaug ib hnub) rau 7-10 hnub, nrog rau kev soj ntsuam xyuas cov zis kom paub meej tias tshem tawm.
Vector-Cov Kab Mob Yug Los:
Ehrlichiosis (ua rauEhrlichia canis) hauv cov dev: koob tshuaj qhov ncauj (10 mg / kg lub cev hnyav ob zaug ib hnub) rau 28 hnub, tshem tawm cov kab mob thiab daws cov tsos mob tshwm sim (ua npaws, qaug zog).
Quality & Safety Assurance
Doxycycline Hyclate ob txoj kev siv rau tib neeg thiab zaub mov- tsim cov tsiaj yuav tsum tau tswj kom zoo, tswj kev tiv thaiv, thiab kev saib xyuas cov seem:
Raw Khoom & Synthesis: Ua los ntawm semi-synthetic hloov kho ntawm oxytetracycline (fermentation-derived) ua raws li purification ntawm crystallization. Cov ntaub ntawv nyoos raws li USP/EP cov qauv rau cov kev txwv tsis pub muaj (piv txwv li, 4-epi-doxycycline Tsawg dua lossis sib npaug li 2.0%, cov khoom lag luam degradation loj).
Txheej txheem ntau lawm:
Pharmaceutical Qib: Ua nyob rau hauv GMP-cov chaw ua haujlwm tau ntawv pov thawj (Class C cleanroom rau txhaj tshuaj- qib raw cov ntaub ntawv) nrog cov cuab yeej siv hluav taws xob tiv thaiv kom tsis txhob muaj teeb pom kev zoo -induced degradation.
Veterinary Qib: Tau txais kev kuaj ntxiv rau tsiaj- cov impurities tshwj xeeb (xws li cov hlau hnyav Tsawg dua lossis sib npaug li 5ppm) thiab ua raws li cov kws kho tsiaj cov kws kho tsiaj rau cov cim seem.
Comprehensive Testing Protocol:
| Cov khoom kuaj | Txoj kev | Kev lees txais |
|---|---|---|
| Purity & Assay | HPLC (C18 kem, 280nm kuaj pom) | Pharmaceutical qib: Ntau dua lossis sib npaug rau 98.0% purity, Ntau dua lossis sib npaug rau 89.0% doxycycline; Veterinary qib: Ntau dua lossis sib npaug rau 95.0% purity |
| Yam khoom muaj feem | HPLC (gradient elution) | 4-epi-doxycycline Tsawg dua lossis sib npaug li 2.0%, tag nrho impurities Tsawg dua lossis sib npaug li 3.0% |
| Hnyav Hlau | ICP-MS (Inductively Coupled Plasma-Mass Spectrometry) | Pb Tsawg dua lossis sib npaug rau 10ppm, Hg Tsawg dua lossis sib npaug rau 1ppm, Cd Tsawg dua lossis sib npaug rau 1ppm |
| Residue Solvents | GC (headspace sampling) | Ethanol Tsawg dua lossis sib npaug rau 500ppm, Methanol Tsawg dua lossis sib npaug rau 300ppm |
| Sterility (Tshwj xeeb txhaj tshuaj) | Membrane filtration method | Tsis muaj kab mob / fungal loj hlob |
Kev ceeb toom kev nyab xeeb:Tib neeg siv:
Contraindications: hypersensitivity rau tetracyclines; menyuam<8 years (causes tooth discoloration and bone growth inhibition); pregnancy/lactation (Category D-fetal harm risk).
Cov teebmeem tsis zoo: Kev tsis xis nyob hauv plab (xws li, raws plab), photosensitivity (tsis txhob raug tshav ntuj ntau), thiab tsis tshua muaj siab hepatotoxicity (saib cov neeg mob siab tsis zoo).
Kev siv Veterinary:
Lub Sijhawm Tshem Tawm: Npua: 5 hnub (nqaij); nyuj: 28 hnub (nqaij), 5 hnub (mis nyuj); Dogs/Cat: Tsis muaj lub sijhawm tshem tawm (tsis yog-cov tsiaj noj).
Kev Ceeb Toom: Tsis txhob siv ntau dhau (piv txwv li, kev noj zaub mov tas li) txhawm rau tiv thaiv kev tshwm sim ntawm doxycycline- cov kab mob resistant (xws li,Salmonellaspp.,E. coli).
Kev koom tes & kev sib cuag
Peb muab Doxycycline Hyclate rau ntau qib thiab cov qauv tsim kom tau raws li cov kev xav tau sib txawv:
Pharmaceutical Qib: Raw hmoov rau lub qhov ncauj ntsiav tshuaj, tshuaj ntsiav, thiab txhaj tshuaj (1kg-100kg ib qho kev txiav txim).
Veterinary Qib: Raw hmoov rau premixes, soluble hmoov, thiab txhaj tshuaj (10kg-500kg ib qho kev txiav txim; txhua hli muaj peev xwm ntawm 800kg).
Tus nqi - cov kev pabcuam ntxiv suav nrog:
Muab DMF (Drug Master File) thiab CEP (Certificate of Suitability) rau cov khoom siv tshuaj - qib los txhawb kev sau npe hauv EU, Asmeskas, thiab Asia.
Customized formulation txoj kev loj hlob (xws li, saj- npog qhov ncauj hmoov rau cov tsiaj nrog, ruaj khov tshuaj daws rau cov tsiaj nyeg).
Kev qhia txog kev tswj xyuas kev tiv thaiv (cov neeg kho tsiaj) thiab kev saib xyuas cov tshuaj tiv thaiv tsis zoo (cov neeg siv tshuaj).
Yog tias koj yog cov chaw tsim tshuaj, kws kho tsiaj ua lag luam, lossis tus khub tsiaj noj qab haus huv tuam txhab, thov hu rau peb kom paub meej kev koom tes:
Cov ntaub ntawv tiv tauj:
Email: sales@huarongpharma.com
Xov tooj/WhatsApp: +86 13751168070
Peb ua raws li cov hauv paus ntsiab lus ntawm "kev ua tau zoo, qhov tseem ceeb ntawm kev nyab xeeb, thiab ntev - yeej- yeej" thiab tos ntsoov rau kev koom tes nrog kev noj qab haus huv thoob ntiaj teb thiab cov tuam txhab kev noj qab haus huv tsiaj!
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