Thiamine hydrochloride (thiamine chloride hydrochloride, Case Tsis muaj.
Raws li tus kws tshaj lij kev ua haujlwm ntawm cov kws ua tshuaj paus {{}}}} dav hlau cov qauv (USP, EP, FCC, GB). Ib qho dej tseem ceeb- soluble b} soluble b} Cov kab vitamin tseem ceeb hauv cov metabolism hauv cov roj carbohydrate thiab nurological. Nws cov dej siab loj solubility thiab zoo heev bioavailability ua rau nws zoo tagnrho rauKws Tshuaj(rau kev kho tsis txaus siab sai sai),Pab Txhawb Nqa, thiabCov Khoom Noj Ua Si Faus{{0 {}}} Txhawb kev noj qab haus huv tib neeg nyob thoob txhua pawg hnub nyoog.
Cov Khoom Siv Khoom Siv Khoom
| Yam | Cov ntsiab lus |
|---|---|
| Khoom npe | Thiamine hydrochloride (thiamine chloride hydrochloride) |
| Cas Tsis tau. | 67-03-8 |
| Txhais lus hais tias | Vitamin B1 hydrochloride; 3 - [(4-amino-2-pyrimidinyl) methyl) -5- hydroxyethyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) -4-Methylthetyl) |
| Molecular Cov Qauv | C₁₂h₁₇n₄o₄s · 2thcl |
| Molecular hnyav | 337.27 |
| Kev tshwm sim | Dawb rau tawm -} e} crystalline hmoov; Ntxhiab, nrog ib qho iab iab me ntsis saj |
| Kev qhia tshwj xeeb | - Kws Tshuaj Ntsuam Xyuas: Purity ntau dua los yog sib npaug rau 99.0% (HPLC); Assisy (raws li thiamine) ntau dua lossis sib npaug rau 89.0% (muaj mob anhydous); Poob rau ziab qis dua lossis sib npaug rau 0.5%; Residue ntawm ignition tsawg dua los yog sib npaug rau 0.1%; Cov hlau hnyav (PB tsawg dua lossis sib npaug ntawm 10ppm, Hg tsawg dua lossis sib npaug ntawm 1PPM, Cd tsawg dua lossis sib npaug lossis sib npaug)}Nutraceutical / Zaub mov Qib Qib: Purity ntau dua los yog sib npaug rau 98.0% (HPLC); Ua raws li FCC / GB cov qauv; Microbial suav (tag nrho aerobic bacteria tsawg dua los yog sib npaug rau 1000 cfu / g, pwm tsawg dua lossis sib npaug nrog 100 cfu / g) |
| Melting taw tes | 248-252 Qib (nrog kev txiav txim siab) |
| So | Dawb soluble hauv dej (ntau dua lossis sib npaug rau 100 g / l ntawm 25 degree); Soluble hauv glycerol; Me ntsis soluble hauv ethanol; Insoluble hauv ether, chloroform |
| Kev Cia | Khaws rau hauv qhov txias (15 {- 25 degree), qhuav, lub teeb-tiv thaiv lub thawv; Zam txhob kis kub, noo noo, thiab ncaj qha rau kev cuam tshuam hauv UV teeb / kub); Txee Lub Neej: 36 lub hlis rau cov qhab nia ntawm Tshuaj, 24 lub hlis rau cov zaub mov / khoom noj khoom haus qib |
Core Functions & Cov Ntawv Thov
Thiamine hydrochloride yog biologically nquag raws li cov vitamin B1, uas hloov pauv mus rau hauv ATTabolism rau lub zog (TPP) {1} {1 {1} Tsis zoo li thiamine nitrate, nws cov dej solubility siab ua rau kev nqus tau sai thiab kev faib tawm hauv lub cev, ua rau qhov kev xaiv zoo tshaj rauCast -} ua yeeb yam khothiabUa kua tsimCov. Nws tau thov rau hauv peb qhov tseem ceeb teb:
1. Kws Kho Mob Daim Duab (Kev Nyab Xeeb Kev Kho Mob & Txhawb Nqa Kev Nyab Xeeb)
1.1 thiav cawv loj heev
Wernicke - korsakoff syndrome (wks): Lub neej {- Kev phom sij ntawm cov kev tsis sib haum xeeb (hauv kev sib daj sib tua) uas tsis meej pem, atflus, thiab tsis pom kev. Muab txoj kev txhaj tshuaj (iv) lossis kev txhaj tshuaj (100 mg txhua hnub rau 3-7 hnub) rau kev kho kom zoo, ua raws li qhov ncauj (50-100 mg txhua hnub).
Ntub Beriberi: Daim ntawv cardiovascular ntawm deficiency ua rau edema thiab lub plawv tsis ua haujlwm. Pib IV / txhij koob (100 mg 2 {4- 3} Txhua hnub) kom ruaj khov plawv (20-30 mg txhua hnub) rau kev tswj hwm ib hnub ntev.
1.2 Kev Tiv Thaiv Kev Ntsuas Rau Cov Me Me & Neurological
Mob ntshav qab zib neuropathy: Ua ke nrog B6 thiab B12 thiab B12 nyob rau hauv cov qauv ntawm hydrochloride ib koob thiab kev ua kom zoo nkauj ntawm lub luag haujlwm thiab kev ua kom zoo nkauj, leverving nws lub luag haujlwm ntawm kev siv hluav taws xob ntawm lub hlwb.
Post - Kev Kho Mob Rov Qab: Ntxiv rau cov kev noj haus niam txiv (pn) daws (5 {}}}}}}}}}}} iatrogenic thiamine tsis muaj mob thaum muaj roj ivbohydrate.
2. Nutraceutical Field (Team Supulationation Txhua Hnub)
B -} cov tshuaj ntsuab & multivitamin ntxiv: Thawj daim ntawv ntawm cov vitamin B1 hauv cov ntsiav tshuaj, tshuaj ntsiav, thiab hmoov noj ib pluag noj (1.1-1.2 mg / hnub). Nws cov sensures ua kom muaj kev sib cais hauv cov kua roj ua khoom noj (piv txwv li, cov tshuaj kho kom zoo, cov ncauj lus ncauj).
Cov tshuaj tiv thaiv:
Rau cov tib neeg uas muaj cov khoom noj muaj carbohydrate (piv txwv li, cov neeg ncaws pob, mob ntshav qab zib): 10-20 mg txhua hnub los pab cov metabolism thiab kev tsim hluav taws xob.
Rau cov laus: 5 {- 10 mg txhua hnub los daws cov hnub nyoog kev poob dej poob thiab txo qis peripheral neuropathy pheej hmoo.
Txog cov neeg siv cawv: 25 {- txhua hnub los tiv thaiv dej cawv uas ua rau thiamine depetion.
3. Cov zaub mov & dej haus teb (FORTICATION)
Cov Khoom Noj Ua Kua & Dej Haus: Qhov zoo tagnrho rau fortifying mis nyuj, nroj tsuag- noj cov mis nyuj (taum pauv (cov dej haus (khoom noj muaj haus) vim nws cov dej so dej siab. Qib Fortification: 0.1-0.5 mg / 100mL.
Menyuam Mos & Pediatric Cov Khoom Noj: Added to liquid infant formula (10-40 ug/100 kcal) and oral drops for infants, ensuring rapid absorption to meet developmental needs.
Tsawg - Cov Khoom Noj Thaum Tshav Kub Kub: Siv rau hauv cov zaub mov, khob cij, thiab khoom noj txom ncauj thaum muaj cua sov (zam kev kub kom tiv thaiv kev ua kom tsis txhob muaj kev ua kom muaj kev tsis pom zoo). Qib Fortification: 0.2-1 mg / 100g.
Kev Ua Tau Zoo & Kev Tsim Kho Kev Nyab Xeeb
Raws li qhov dav dav siv cov khoom siv tseem ceeb, Thiamine hydrochloride yuav tsum muaj kev tswj hwm zoo kom ntseeg tau, bioavailability, thiab kev nyab xeeb:
Cov Khoom Siv Raw & Synthesis: Cov khoom siv hluav taws xob hluavtaws (hws ntawm 4-amino-2-hydroxyethyl)-4-mthylorthiazole, tom qab los ntawm hydrochlorination) thiab lim kom huv) thiab huv ntawm recrystallization. Cov ntaub ntawv nyoos ntsib USP / EP qauv rau impuration txwv (piv txwv li, Thiamine decomposition cov khoom tsawg dua los yog sib npaug 0.1%).
Cov txheej txheem ntau lawm:
Kws Tshuaj Ntsuam Xyuas: Tsim nyob rau hauv GMP - Daim ntawv cog lus ua haujlwm (chav kawm DUA-} d
Nutraceutical / Zaub mov Qib Qib: Undergoes ntxiv microbial kev sim thiab ua raws li kev nyab xeeb zaub mov muaj kev nyab xeeb zaub mov (piv txwv li, FDA 21 CFR rau cov khoom noj ntxiv).
Kev Ntsuas Xyuas Cov Quav:
| Ntsuas Yam | Txojkev | Kev lees txais cov txheej txheem |
|---|---|---|
| Purity & Assay | HPLC (C18, 246 NM Nrhiav Kom Tau) | Kws tsim qauv qib: ntau dua los yog sib npaug ntawm 99.0% purity, ntau dua los yog sib npaug rau 89.0% thiamine; Nutraceutical Qib: ntau dua los yog sib npaug rau 98.0% purity |
| Lwm yam tshuaj | HPLC (Gradient Elfution) | Ib leeg impurity tsawg dua los yog sib npaug rau 0.1%, tag nrho cov impurities tsawg dua los yog sib npaug rau 0.5% |
| Cov hlau hnyav | ICP - ms (inductively coupled ntshav -} cov spectrometry) | PB tsawg dua lossis sib npaug rau 10ppm, Hg tsawg dua lossis sib npaug ntawm 1PPM, Cd tsawg dua lossis sib npaug lossis sib npaug |
| Cov me me paug | Phaj Suav Txoj Kev | Nutraceutical / Zaub mov qib: Tag nrho aerobic bacteria tsawg dua los yog sib npaug rau 1000 cfu / g, pwm tsawg dua lossis sib npaug nrog 100 cfu / g |
| Kev Kuaj Solubility | Txoj kev gravimetric | Ntau dua los yog sib npaug rau 100 g / l nyob rau hauv dej (25 degree), tshem tawm kev daws teeb meem |
Kev Nyab Xeeb Kev Nyab Xeeb:
Lom zem: Muaj kev nyab xeeb rau cov koob tshuaj. Txawm hais tias siab qhov ncauj (100 {{- 500 mg ib hnub) yog kev ua kom zoo nkauj tsis muaj zog (xeev siab, cov tawv nqaij flushing).
Yam sib pauv: Hypersensitivity rau thiamine lossis chloride salts (tsawg); Tsis muaj lwm yam uas paub cov teeb meem.
Ceev faj ceev faj: Degrades nyob rau hauv UV teeb thiab siab kub -}}}}}} nitrate cov zaub mov ua (xaiv rau thiamine nyob rau hauv cov xwm txheej zoo li no).
Kev Koom Tes & Hu
Peb muab thiamine hydrochloride hauv ntau qib thiab lub cev daim ntawv kom tau sib ntsib ntau yam kev thov nyiaj:
Kws Tshuaj Ntsuam Xyuas: Hmoov zoo crystalline hmoov (1kg-100kg ib qho kev txiav txim) rau cov ntsiav tshuaj, thiab cov duab ua niam ua txiv.
Nutraceutical / Zaub mov Qib Qib: Hmoov los yog granular daim ntawv (10kg-500kg ib zaug muaj peev xwm ntawm 2000kg) rau cov tshuaj, cov kua mis, thiab cov mis mos.
Tus nqi -} muaj kev pabcuam ntxiv nrog:
Muab cov ntaub ntawv DMF (cov ntaub ntawv tshuaj) thiab CEP (Daim Ntawv Pov Thawj ntawm Kev Ua Haujlwm) rau cov khoom lag luam qib kawm los txhawb hauv EU, peb, thiab Asia.
Kev Ua Tau: Micronization (rau Tsawg - cov tshuaj noj) lossis kua quav rau (rau fowerage fortification).
Kev Txhawb Nqa: Cov ntaub ntawv ruaj khov rau cov qauv sib txawv thiab cov kev taw qhia ntawm kev zam kev ua kom tsis txhob muaj kev cuam tshuam.
Yog tias koj yog cov chaw tsim tshuaj paus, ntxiv hom, khoom noj khoom haus / dej qab zib tsim khoom, lossis lub tuam txhab tsis muaj npe, thov hu rau peb kom paub meej kev koom tes:
Cov ntaub ntawv tiv toj:
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Peb ua raws li cov ntsiab cai ntawm "kev coj dawb huv, Bioavailability muaj feem thib, thiab tos ntsoov koom tes nrog ntiaj teb kev noj qab haus huv hauv ntiaj teb thiab kev lag luam khoom noj khoom haus!
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